HR job title
- Technical Laboratory Coordinator
- Contact Info
- 1 979 458 5840
- Websites
- ORCiD
- 0000-0002-8130-6997
Chaki, Sankar Associate Research Scientist
Positions
- Associate Research Scientist, Division of Research, Office of the President
An experienced Biologist with significant basic, translational and regulatory research in infectious diseases (Brucellosis, Anthrax, SARS-CoV2), cell & molecular biology, molecular genetics, cancer and reproductive physiology. Multiple peer-reviewed research publications, patents, and success in classroom/ laboratory teaching, laboratory management and providing training to work in high containment laboratories (ABSL2, BSL3 and ABSL3). Eager to contribute to research & development (vaccines and diagnostics), education, training, and biosafety management.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
- Other
- View All
Overview
Publications
selected publications
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academic article
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Mulgaonkar, N., Wang, H., Zhang, J., Roundy, C. M., Tang, W., Chaki, S. P., ... Fernando, S.
(2023).
Montelukast and Telmisartan as Inhibitors of SARS-CoV-2 Omicron Variant. Pharmaceutics.
15(7), 1891-1891.
-
De la Rosa-Ramos, M. A., Arellano-Reynoso, B., Hernndez-Badillo, E., Guerra-Infante, F. M., Mancilla-Herrera, I., Chaki, S. P., Ficht, T. A., & Surez-Gemes, F.
(2023).
Evaluation of the goat cellular immune response to rBtuB-Hia-FlgK peptides from Brucella melitensis. Comparative Immunology, Microbiology and Infectious Diseases: the international journal for medical and veterinary researchers and practitioners.
94, 101944-101944.
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Chaki, S. P., Kahl-McDonagh, M. M., Neuman, B. W., & Zuelke, K. A.
(2022).
Receptor-Binding-Motif-Targeted Sanger Sequencing: a Quick and Cost-Effective Strategy for Molecular Surveillance of SARS-CoV-2 Variants. Microbiology Spectrum.
10(3), e0066522-e00622.
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Cao, W., Cho, C., Geng, Z. Z., Shaabani, N., Ma, X. R., Vatansever, E. C., ... Liu, W. R.
(2022).
Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay. ACS Central Science.
8(2), 192-204.
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Neuman, B. W., Brashear, W. A., Brun, M., Chaki, S. P., Fischer, R., Guidry, S. J., ... Zuelke, K.
(2021).
Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE.
105(5), 1227-1229.
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Benn, J. S., Chaki, S. P., Xu, Y. i., Ficht, T. A., Rice-Ficht, A. C., & Cook, W. E.
(2021).
Author Correction: Protective antibody response following oral vaccination with microencapsulated Bacillus Anthracis Sterne strain 34F2 spores. NPJ Vaccines.
6(1), 109.
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Costa, L. F., Cabello, A. L., Batista, D., Chaki, S. P., de Figueiredo, P., da Paixo, T. A., ... Santos, R. L.
(2020).
The candidate vaccine strain Brucella ovis abcBA is protective against Brucella melitensis infection in mice. Microbiology and Immunology.
64(11), 730-736.
-
Hensel, M. E., Chaki, S. P., Stranahan, L., Gregory, A. E., van Schaik, E. J., Garcia-Gonzalez, D. G., ... Arenas-Gamboa, A. M.
(2020).
Intratracheal Inoculation with Brucella melitensis in the Pregnant Guinea Pig Is an Improved Model for Reproductive Pathogenesis and Vaccine Studies. Infection and Immunity.
88(10), e00204-e00220.
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Benn Felix, J., Chaki, S. P., Xu, Y. i., Ficht, T. A., Rice-Ficht, A. C., & Cook, W. E.
(2020).
Protective antibody response following oral vaccination with microencapsulated Bacillus Anthracis Sterne strain 34F2 spores. NPJ Vaccines.
5(1), 59.
-
Stranahan, L. W., Chaki, S. P., Garcia-Gonzalez, D. G., Khalaf, O. H., & Arenas-Gamboa, A. M.
(2020).
Evaluation of the Efficacy of the Brucella canis RM6/66 vjbR Vaccine Candidate for Protection against B. canis Infection in Mice. mSphere.
5(3), e00172-e00120.
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Hensel, M. E., Garcia-Gonzalez, D. G., Chaki, S. P., Hartwig, A., Gordy, P. W., Bowen, R., Ficht, T. A., & Arenas-Gamboa, A. M.
(2020).
Vaccine Candidate Brucella melitensis 16MvjbR Is Safe in a Pregnant Sheep Model and Confers Protection. mSphere.
5(3), e00120-e00120.
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Khalaf, O. H., Chaki, S. P., Garcia-Gonzalez, D. G., Suva, L. J., Gaddy, D., & Arenas-Gamboa, A. M.
(2020).
Interaction of Brucella abortus with Osteoclasts: a Step toward Understanding Osteoarticular Brucellosis and Vaccine Safety. Infection and Immunity.
88(4), e00822-e00819.
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Stranahan, L. W., Chaki, S. P., Garcia-Gonzalez, D. G., Khalaf, O. H., & Arenas-Gamboa, A. M.
(2020).
Evaluation of the Efficacy of the Brucella canis RM6/66 Delta vjbR Vaccine Candidate for Protection against B. canis Infection in Mice. mSphere.
5(3),
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Benn Felix, J., Chaki, S. P., Xu, Y. i., Ficht, T. A., Rice-Ficht, A. C., & Cook, W. E.
(2020).
Protective antibody response following oral vaccination with microencapsulated Bacillus Anthracis Sterne strain 34F2 spores. NPJ Vaccines.
5(1), 59.
-
Chaki, S. P., Barhoumi, R., & Rivera, G. M.
(2019).
Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion. Cancer Medicine.
8(17), 7385-7398.
-
Hensel, M. E., Garcia-Gonzalez, D. G., Chaki, S. P., Samuel, J., & Arenas-Gamboa, A. M.
(2019).
Correction: Characterization of an intratracheal aerosol challenge model of Brucella melitensis in guinea pigs. PLoS One.
14(6), e0218065-e0218065.
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Khalaf, O. H., Chaki, S. P., Garcia-Gonzalez, D. G., Ficht, T. A., & Arenas-Gamboa, A. M.
(2019).
The NOD-scid IL2rnull Mouse Model Is Suitable for the Study of Osteoarticular Brucellosis and Vaccine Safety. Infection and Immunity.
87(6),
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de Figueiredo, P., Pandey, A., Ding, S., Qin, Q., Gupta, R., Gomez, G., ... Ficht, T. A.
(2019).
Mechanisms controlling Cryptococcus Intracellular Parasitism. JOURNAL OF IMMUNOLOGY.
202(1_Supplement), 190.31-190.31.
-
Hensel, M. E., Garcia-Gonzalez, D. G., Chaki, S. P., Samuel, J., & Arenas-Gamboa, A. M.
(2019).
Characterization of an intratracheal aerosol challenge model of Brucella melitensis in guinea pigs. PLoS One.
14(3), e0212457-e0212457.
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Zriba, S., Garcia-Gonzalez, D. G., Khalaf, O. H., Wheeler, L., Chaki, S. P., Rice-Ficht, A., Ficht, T. A., & Arenas-Gamboa, A. M.
(2019).
Vaccine safety studies of Brucella abortus S19 and S19vjbR in pregnant swine. Vaccine: X.
3, 100041-100041.
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Benn Felix, J., Chaki, S. P., Ficht, T. A., Rice-Ficht, A. C., & Cook, W.
(2019).
Bacillus anthracis Sterne Strain 34f2 Vaccine Antibody Dose Response by Subcutaneous and Oral Administration. Poultry Fisheries & Wildlife Sciences.
07(02), 1-6.
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Morris, D. C., Popp, J. L., Tang, L. K., Gibbs, H. C., Schmitt, E., Chaki, S. P., ... Rivera, G. M.
(2017).
Nck deficiency is associated with delayed breast carcinoma progression and reduced metastasis. Molecular Biology of the Cell.
28(24), 3500-3516.
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Pandey, A., Ding, S. L., Qin, Q., Gupta, R., Gomez, G., Lin, F., ... de Figueiredo, P.
(2017).
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection. Cell Host and Microbe.
21(5), 637-649.e6.
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Arenas-Gamboa, A. M., Rossetti, C. A., Chaki, S. P., Garcia-Gonzalez, D. G., Adams, L. G., & Ficht, T. A.
(2016).
Human Brucellosis and Adverse Pregnancy Outcomes. Current Tropical Medicine Reports.
3(4), 164-172.
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Chaki, S. P., Barhoumi, R., & Rivera, G. M.
(2015).
Actin remodeling by Nck regulates endothelial lumen formation. Molecular Biology of the Cell.
26(17), 3047-3060.
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Chaki, S. P., Barhoumi, R., & Rivera, G. M.
(2015).
Abstract 421: Nck Promotes Podosome Formation and Function in Vascular Endothelial Cells. Circulation Research.
117(suppl_1),
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Lee, H. S., Cheerathodi, M., Chaki, S. P., Reyes, S. B., Zheng, Y., Lu, Z., ... McCarty, J. H.
(2015).
Protein tyrosine phosphatase-PEST and 8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Molecular and Cellular Biology.
35(8), 1401-1413.
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Sreenivasappa, H., Chaki, S. P., Lim, S., Trzeciakowski, J. P., Davidson, M. W., Rivera, G. M., & Trache, A.
(2014).
Selective regulation of cytoskeletal tension and cell-matrix adhesion by RhoA and Src. Integrative Biology: interdisciplinary approaches for molecular and cellular life sciences.
6(8), 743-754.
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Chaki, S. P., & Rivera, G. M.
(2013).
Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration. BioArchitecture.
3(3), 57-63.
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Chaki, S. P., Barhoumi, R., Berginski, M. E., Sreenivasappa, H., Trache, A., Gomez, S. M., & Rivera, G. M.
(2013).
Nck enables directional cell migration through the coordination of polarized membrane protrusion with adhesion dynamics. Journal of Cell Science.
126(Pt 7), 1637-1649.
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Das, P. J., Paria, N., Gustafson-Seabury, A., Vishnoi, M., Chaki, S. P., Love, C. C., ... Raudsepp, T.
(2010).
Total RNA isolation from stallion sperm and testis biopsies. THERIOGENOLOGY.
74(6), 1099-1106e2.
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Misro, M. M., Chaki, S. P., Kaushik, M. C., & Nandan, D.
(2009).
Trials for development of once-a-month injectable, hormonal male contraceptive using dienogest plus testosterone undecanoate: dose standardization, efficacy and reversibility studies in rats. Contraception.
79(6), 488-497.
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Saxena, P., Misro, M. M., Chaki, S. P., Chopra, K., Roy, S., & Nandan, D.
(2008).
Is abnormal sperm function an indicator among couples with recurrent pregnancy loss?. Fertility and Sterility.
90(5), 1854-1858.
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Misro, M. M., Chaki, S. P., Chandra, M., Maheshwari, A., & Nandan, D.
(2008).
Release of copper from CuT 380A co-incubated with human semen and its effect on sperm function in vitro. Indian journal of physiology and pharmacology.
52(3), 267-273.
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Misro, M. M., & Chaki, S. P.
(2008).
Development of a rapid, sensitive, and reproducible laboratory test kit for the assessment of plasma membrane integrity of human sperm. Fertility and Sterility.
89(1), 223-227.
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Gautam, D. K., Misro, M. M., Chaki, S. P., Chandra, M., & Sehgal, N.
(2007).
hCG treatment raises H2O2 levels and induces germ cell apoptosis in rat testis. Apoptosis: an international journal on programmed cell death.
12(7), 1173-1182.
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Chaki, S. P., Misro, M. M., Gautam, D. K., Kaushik, M., Ghosh, D., & Chainy, G. B.
(2006).
Estradiol treatment induces testicular oxidative stress and germ cell apoptosis in rats. Apoptosis: an international journal on programmed cell death.
11(8), 1427-1437.
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Misro, M. M., & Chaki, S. P.
(2006).
Emergency Contraception: Current Methods, Usages and Issues. Current Women's Health Reviews.
2(1), 33-39.
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Gautam, D. K., Misro, M. M., Chaki, S. P., & Sehgal, N.
(2006).
H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis. Apoptosis: an international journal on programmed cell death.
11(1), 39-46.
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Misro, M. M., Chaki, S. P., & Gautam, D. K.
(2005).
Germ cell death and their removal during initial stages of testicular ischemia and cryptorchidism: a comparative analysis. Indian Journal of Experimental Biology.
43(11), 1080-1087.
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Chaki, S. P., Misro, M. M., Ghosh, D., Gautam, D. K., & Srinivas, M.
(2005).
Apoptosis and cell removal in the cryptorchid rat testis. Apoptosis: an international journal on programmed cell death.
10(2), 395-405.
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Misro, M. M., Choudhury, L., Upreti, K., Gautam, D., Chaki, S. P., Mahajan, A. S., & Babbar, R.
(2004).
Use of hydrogen peroxide to assess the sperm susceptibility to oxidative stress in subjects presenting a normal semen profile. International Journal of Andrology.
27(2), 82-87.
-
Chaki, S. P., Ghosh, D., & Misro, M. M.
(2003).
Simultaneous increase in germ cell apoptosis and oxidative stress under acute unilateral testicular ischaemia in rats. International Journal of Andrology.
26(6), 319-328.
-
Chandrasekharam, V., Srinivas, M., Das, S. N., Jha, P., Bajpai, M., Chaki, S. P., & Misro, M. M.
(2003).
Prepubertal human chorionic gonadotropin injection affects postpubertal germ cell maturation and androgen production in rat testis. Urology.
62(3), 571-574.
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Srinivas, M., Degaonkar, M., Jagannathan, N. R., Misro, M. M., Chaki, S. P., & Gupta, D. K.
(2003).
Protective role of cyclosporine in experimental unilateral blunt testicular trauma: evaluation by 31P MR spectroscopy. Pediatric Surgery International.
19(6), 467-470.
-
Chaki, S. P., Das, H. C., & Misro, M. M.
(2003).
A short-term evaluation of semen and accessory sex gland function in phase III trial subjects receiving intravasal contraceptive RISUG. Contraception.
67(1), 73-78.
-
Upreti, K., Chaki, S. P., & Misro, M. M.
(2002).
Evaluation of peroxidative stress and enzymatic antioxidant activity in liver and kidney during pregnancy and lactation in rats. Health and Population: Perspectives and Issues.
25(4), 177-185.
-
Chaki, S. P., & Misro, M. M.
(2002).
Assessment of human sperm function after hydrogen peroxide exposure. development of a vaginal contraceptive. Contraception.
66(3), 187-192.
-
Chaube, S. K., Chaki, S. P., & Misro, M. M.
(2000).
Effects of pentoxlfylline and caffeine on spontaneous maturation of rat ocytes. Health and Population: Perspectives and Issues.
23(4), 177-189.
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Chattopadhyay, S., Ghosh, S., Chaki, S., Debnath, J., & Ghosh, D.
(1999).
Effect of sodium arsenite on plasma levels of gonadotrophins and ovarian steroidogenesis in mature albino rats: duration-dependent response. The Journal of Toxicological Sciences.
24(5), 425-431.
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Misro, M. M., Chaki, S. P., Srinivas, M., & Chaube, S. K.
(1999).
Effect of cyclosporine on human sperm motility in vitro. Systems Biology in Reproductive Medicine.
43(3), 215-220.
-
Mulgaonkar, N., Wang, H., Zhang, J., Roundy, C. M., Tang, W., Chaki, S. P., ... Fernando, S.
(2023).
Montelukast and Telmisartan as Inhibitors of SARS-CoV-2 Omicron Variant. Pharmaceutics.
15(7), 1891-1891.
-
conference paper
-
de Figueiredo, P., Pandey, A., Ding, S., Qin, Q., Gupta, R., Gomez, G., ... Ficht, T. A.
(2019).
Mechanisms controlling Cryptococcus Intracellular Parasitism. 190.31.
-
Chaki, S. P., Barhoumi, R., & Rivera, G. M.
(2015).
Nck Promotes Podosome Formation and Function in Vascular Endothelial Cells. Circulation Research.
-
Sreenivasappa, H., Chaki, S. P., Lim, S., Trzeciakowski, J. P., Davidson, M. W., Rivera, G. M., & Trache, A.
(2014).
Functional coupling between adhesion strength and cell stiffness depends on cytoskeletal tension modulation. Molecular Biology of the Cell.
-
Chaki, S. P., Barhoumi, R., & Rivera, G. M.
(2014).
Nck Regulate Endothelial Cell Morphogenesis by Modulating the Activity of Cdc42. Molecular Biology of the Cell.
-
Sreenivasappa, H., Lim, S., Chaki, S., Trzeciakowski, J. P., Davidson, M. W., Rivera, G., & Trache, A.
(2013).
RhoA-src crosstalk modulates cell stiffness and adhesion to the matrix. ACS National Meeting Book of Abstracts.
-
Chaki, S. P., Barhoumi, R., Yog, R., Berginski, M. E., Gomez, S. M., & Rivera, G. M.
(2011).
Nck Is Required for Focal Adhesion Maturation and Polarized Cell Motility. Molecular Biology of the Cell.
-
de Figueiredo, P., Pandey, A., Ding, S., Qin, Q., Gupta, R., Gomez, G., ... Ficht, T. A.
(2019).
Mechanisms controlling Cryptococcus Intracellular Parasitism. 190.31.
-
institutional repository document
-
Khatua, K., Alugubelli, Y. R., Yang, K. S., Vulupala, V. R., Blankenship, L. R., Coleman, D. D., ... Liu, W. R.
(2023).
An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease
-
Hensel, M. E., Garcia-Gonzalez, D. G., Chaki, S. P., Samuel, J., & Arenas-Gamboa, A. M.
(2018).
Characterization of a novel intratracheal aerosol challenge model of Brucella melitensis in guinea pigs
-
Khatua, K., Alugubelli, Y. R., Yang, K. S., Vulupala, V. R., Blankenship, L. R., Coleman, D. D., ... Liu, W. R.
(2023).
An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease
Research
principal investigator on
- Role of Nck in the expression and activation of matrix metalloproteinases in vascular endothelial cells awarded by Texas A&M University - (College Station, Texas, United States) 2014 - 2015
- Role of Nck adaptors in podosome biogenesis awarded by American Heart Association - (New York, New York, United States) 2013 - 2015
- Molecular mechanism under endothelial morphogenesis awarded by Texas A&M University - (College Station, Texas, United States) 2010 - 2011
co-principal investigator on
investigator on
Teaching
teaching activities
- BIMS481 Seminar In Biomed Sci Instructor
- BIMS489 Sptp: 21st Cent Biol Threats Instructor
- VPAT640 Advanced Mechanisms Of Disease Instructor
Background
education and training
- Ph.D. in Physiology, Vidyasagar University - (Medinīpur, India) 2005
- M.Sc. in Human Physiology, 1st class with University Silver Medal, Vidyasagar University - (Medinīpur, India) 1994
Contact
first name
- Sankar
has last name
- Chaki
mailing address
-
Texas A&M University
GHRC
495 Agronomy Rd
College Station, TX 77843
USA
Other
In the News
- First oral anthrax vaccine for livestock, wildlife News Release
- spchaki@tamu.edu