abstract Having three copies of chromosome 21 reduces the incidence of solid tumours in people with Down's syndrome. Studies in mice provide clues to why, and highlight a complex gene-function relationship. 2008 Nature Publishing Group.
keywords Animals Chromosomes, Mammalian Disease Models, Animal Down Syndrome Female Gene Dosage Genes, APC Humans Male Mice Neoplasms Proto-Oncogene Protein C-ets-2 Trisomy