Down's syndrome: paradox of a tumour repressor. Academic Article

abstract

• Having three copies of chromosome 21 reduces the incidence of solid tumours in people with Down's syndrome. Studies in mice provide clues to why, and highlight a complex gene-function relationship. 2008 Nature Publishing Group.

authors

• Threadgill, David

published proceedings

• Nature

author list (cited authors)

• Threadgill, D. W.

citation count

• 10

complete list of authors

• Threadgill, David W

publication date

• January 2008

publisher

• Springer Nature  Publisher

published in

• Nature  Journal

keywords

• Animals
• Chromosomes, Mammalian
• Disease Models, Animal
• Down Syndrome
• Female
• Gene Dosage
• Genes, APC
• Humans
• Male
• Mice
• Neoplasms
• Proto-Oncogene Protein C-ets-2
• Trisomy

PubMed Central ID

• 18172483

Digital Object Identifier (DOI)

• 10.1038/451021a

start page

• 21

end page

• 22

volume

• 451

issue

• 7174

URL

• http://dx.doi.org/10.1038/451021a