Bayesian Multiple Quantitative Trait Loci Mapping for Complex Traits Using Markers of the Entire Genome
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A Bayesian methodology has been developed for multiple quantitative trait loci (QTL) mapping of complex binary traits that follow liability threshold models. Unlike most QTL mapping methods where only one or a few markers are used at a time, the proposed method utilizes all markers across the genome simultaneously. The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer.
author list (cited authors)
Huang, H., Eversley, C. D., Threadgill, D. W., & Zou, F.