Bayesian Multiple Quantitative Trait Loci Mapping for Complex Traits Using Markers of the Entire Genome Academic Article uri icon

abstract

  • A Bayesian methodology has been developed for multiple quantitative trait loci (QTL) mapping of complex binary traits that follow liability threshold models. Unlike most QTL mapping methods where only one or a few markers are used at a time, the proposed method utilizes all markers across the genome simultaneously. The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer.

author list (cited authors)

  • Huang, H., Eversley, C. D., Threadgill, D. W., & Zou, F.

citation count

  • 13

publication date

  • May 2007