Syntenic conservation between humans and cattle. II. Human chromosome 12. Academic Article

abstract

• Bovine X hamster and bovine X mouse hybrid somatic cells have been used to investigate the syntenic relationship of nine loci in the bovine that have homologous loci on human chromosome 12. Eight loci, including A2M, GLI, HOX3, IFNG, INT1, KRAS2, NKNB, and PAH, were assigned to the previously identified bovine syntenic group U3 represented by GAPD. However, a single locus from the q-terminus of HSA 12, ALDH2, mapped to a new, previously unidentified autosomal syntenic group. These results indicate the existence of a very large ancestral syntenic group spanning from the p-terminus to q24 of HSA 12 and containing over 4% of the mammalian genome. Additionally, the results predict that ALDH2 is distal to PAH and IFNG on HSA 12, the type II keratin gene complex will reside between q11 and q21 of HSA 12, A2M will map to MMU 6, and LALBA and GLI will map to MMU 15.

authors

• Threadgill, David

published proceedings

• Genomics

author list (cited authors)

• Threadgill, D. W., Adkison, L. R., & Womack, J. E.

citation count

• 38

complete list of authors

• Threadgill, DW||Adkison, LR||Womack, JE

publication date

• September 1990

publisher

• Elsevier  Publisher

published in

• Genomics  Journal

keywords

• Animals
• Base Sequence
• Blotting, Southern
• Cattle
• Chromosome Mapping
• Chromosomes, Human, Pair 12
• Cricetinae
• DNA
• DNA Probes
• Humans
• Hybrid Cells
• Mice
• Sequence Homology, Nucleic Acid

PubMed Central ID

• 2081597

Digital Object Identifier (DOI)

• 10.1016/0888-7543(90)90222-g

start page

• 29

end page

• 34

volume

• 8

issue

• 1

URL

• http://dx.doi.org/10.1016/0888-7543(90)90222-g