HR job title
- Professor
- Contact Info
- 9794360633
- Websites
- ORCiD
- 0000-0002-9734-6176
Song, Jianxun Professor
Positions
T cell biology
T cell-based immunotherapy
Cell metabolism
T cell-based immunotherapy
Cell metabolism
Research Areas
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
- Other
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Overview
Publications
selected publications
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academic article
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Ballard, D. J., Peng, H., Das, J. K., Kumar, A., Wang, L., Ren, Y., ... Song, J.
(2021).
Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase. Frontiers in Molecular Biosciences.
8, 727863.
-
Wang, L., Das, J. K., Kumar, A., Peng, H., Ren, Y., Xiong, X., Yang, J., & Song, J.
(2021).
Autophagy in T-cell differentiation, survival and memory. Immunology and Cell Biology.
99(4), 351-360.
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Haque, M., Lei, F., Xiong, X., Ren, Y., Peng, H., Wang, L., ... Song, J.
(2021).
Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HIV Replication and PD-1 Expression on CD4+ T Cells. Viruses.
13(5), 753-753.
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Haque, M., Xiong, X., Lei, F., Das, J. K., & Song, J.
(2021).
An optimized protocol for the generation of HBV viral antigen-specific T lymphocytes from pluripotent stem cells. STAR Protocols.
2(1), 100264-100264.
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Peng, H., Lucavs, J., Ballard, D., Das, J. K., Kumar, A., Wang, L., ... Song, J.
(2021).
Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity. Front Immunol.
12, 652687.
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Fan, J., Das, J. K., Xiong, X., Chen, H., & Song, J.
(2021).
Development of CAR-T Cell Persistence in Adoptive Immunotherapy of Solid Tumors. Frontiers in Oncology.
10, 574860.
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Fan, J., Wang, M., Chen, H., Shang, D., Das, J. K., & Song, J.
(2020).
Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma. Molecular Cancer.
19(1), 32.
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Haque, M., Lei, F., Xiong, X., Ren, Y., Kumar, A., Das, J. K., ... Song, J.
(2020).
Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HBV Replication through Production of IFN-γ and TNF-⍺. iScience.
23(7), 101333-101333.
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Xuan, X., Zhou, J., Tian, Z., Lin, Y., Song, J., Ruan, Z., ... Yang, W.
(2020).
ILC3 cells promote the proliferation and invasion of pancreatic cancer cells through IL-22/AKT signaling. Clinical and Translational Oncology.
22(4), 563-575.
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Das, J. K., Xiong, X., Ren, X., Yang, J., & Song, J.
(2019).
Heat Shock Proteins in Cancer Immunotherapy. Journal of Oncology.
2019, 3267207-9.
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Yang, P., Huang, X., Lai, C., Li, L., Li, T., Huang, P., ... Zhang, S.
(2019).
SET domain containing 1B gene is mutated in primary hepatic neuroendocrine tumors. INTERNATIONAL JOURNAL OF CANCER.
145(11), 2986-2995.
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(2019).
Generation of Tumor Antigen-Specific Cytotoxic T Lymphocytes from Pluripotent Stem Cells. Methods Mol Biol.
1884, 43-55.
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Haque, M., Das, J. K., Xiong, X., & Song, J.
(2019).
Targeting Stem Cell-Derived Tissue-Associated Regulatory T Cells for Type 1 Diabetes Immunotherapy. Current Diabetes Reports.
19(10), 89.
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Xiong, X., Lei, F., Haque, M., & Song, J.
(2019).
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice. Journal of Visualized Experiments.
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Chen, X., Lei, F., Wang, L., Xiong, X., & Song, J.
(2019).
In Vitro Differentiation of T Cells from Murine Pluripotent Stem Cells. Methods Mol Biol.
2048, 131-141.
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Wang, X., Ji, C., Zhang, H., Shan, Y. u., Ren, Y., Hu, Y., ... Zhang, Y. i.
(2019).
Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. Journal of Biological Chemistry.
294(25), 10006-10017.
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Haque, M., Lei, F., Xiong, X., Das, J. K., Ren, X., Fang, D., ... Song, J.
(2019).
Stem cell-derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes. JCI INSIGHT.
4(7),
-
(2018).
Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?. Theranostics.
8(20), 5784-5800.
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Yang, Y. i., Kong, S., Zhang, Y., Melo-Cardenas, J., Gao, B., Zhang, Y., ... Fang, D.
(2018).
The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice. Journal of Biological Chemistry.
293(33), 12934-12944.
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Xiong, X., Das, J. K., Song, J., Ni, B., Ren, X., Yang, J., & Song, J.
(2018).
Protective Cancer Vaccine Using Genetically Modified Hematopoietic Stem Cells. Vaccines.
6(3), 40-40.
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Desai, P., Tahiliani, V., Hutchinson, T. E., Dastmalchi, F., Stanfield, J., Abboud, G., ... Salek-Ardakani, S.
(2018).
The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection. J Immunol.
200(8), 2894-2904.
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Ji, C., Xu, Q., Guo, L., Wang, X., Ren, Y., Zhang, H., ... Zhang, Y. i.
(2018).
eEF-2 Kinase-targeted miR-449b confers radiation sensitivity to cancer cells. CANCER LETTERS.
418, 64-74.
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(2017).
HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity. J Immunol.
199(8), 2968-2975.
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Zhang, Y., Ren, Y., Guo, L., Ji, C., Hu, J., Zhang, H., ... Yang, J.
(2017).
Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis. Oncogene.
36(29), 4171-4181.
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(2017).
Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells. OncoImmunology.
6(7), e1334027-e1334027.
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Jia, H., Truica, C. I., Wang, B., Wang, Y., Ren, X., Harvey, H. A., Song, J., & Yang, J.
(2017).
Immunotherapy for triple-negative breast cancer: Existing challenges and exciting prospects. Drug Resistance Updates.
32, 1-15.
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(2017).
The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation. J Immunol.
198(10), 3927-3938.
-
(2017).
Hepatitis B Virus Immunopathology, Model Systems, and Current Therapies. Front Immunol.
8(APR), 436.
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(2017).
c-Myc-Induced Survivin Is Essential for Promoting the Notch-Dependent T Cell Differentiation from Hematopoietic Stem Cells. Genes.
8(3), 97-97.
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(2016).
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity. Journal of Visualized Experiments.
2016(117),
-
(2016).
The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. NATURE COMMUNICATIONS.
7(1), 12073.
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(2016).
Development of Auto Antigen-specific Regulatory T Cells for Diabetes Immunotherapy. Immune Network.
16(5), 281-285.
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(2016).
Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases. International Reviews of Immunology.
35(5), 399-414.
-
(2016).
Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity. Scientific Reports.
6(1), 20588.
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(2016).
Innate lymphoid cells as novel regulators of obesity and its-associated metabolic dysfunction. Obesity Reviews.
17(6), 485-498.
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Song, J.
(2016).
Stem Cell-Derived Regulatory T Cells for Therapeutic Use in Arthritis. Autoimmune and Infectious Diseases Open Access.
2(3), 10.16966/2470-10.161025.119.
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Haque, M., Song, J., Fino, K., Sandhu, P., Wang, Y., Ni, B., Fang, D., & Song, J.
(2016).
Melanoma Immunotherapy in Mice Using Genetically Engineered Pluripotent Stem Cells. CELL TRANSPLANTATION.
25(5), 811-827.
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Xu, A., Liu, Y. a., Chen, W., Wang, J., Xue, Y., Huang, F., ... Zheng, S. G
(2016).
TGF-β-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism. J Immunol.
196(9), 3631-3641.
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(2016).
C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. Open Biol.
6(1), 150208-150208.
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Ündar, A., Wang, S., Palanzo, D. A., Wise, R. K., Woitas, K., Baer, L. D., ... Myers, J. L.
(2016).
Impact of Pulsatile Flow on Vital Organ Recovery During Cardiopulmonary Bypass in Neonates and Infants. Artif Organs.
40(1), 14-18.
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Haque, M., Fino, K., & Song, J.
(2015).
Stem cell-derived tissue- associated regulatory T cells ameliorate the development of autoimmune arthritis. J Immunother Cancer.
3(S2), p21-p21.
-
(2015).
Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKα Phosphorylation. J Immunol.
195(8), 3685-3693.
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Wang, S., Krawiec, C., Patel, S., Kunselman, A. R., Song, J., Lei, F., Baer, L. D., & Ündar, A.
(2015).
Laboratory Evaluation of Hemolysis and Systemic Inflammatory Response in Neonatal Nonpulsatile and Pulsatile Extracorporeal Life Support Systems. Artif Organs.
39(9), 774-781.
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Aĝirbaşli, M., Song, J., Lei, F., Wang, S., Kunselman, A. R., Clark, J. B., Myers, J. L., & Ündar, A.
(2015).
Apolipoprotein E levels in pediatric patients undergoing cardiopulmonary bypass. Artif Organs.
39(1), 28-33.
-
(2014).
Modulation of autoimmune diseases by iPS cells. Methods Mol Biol.
1213, 365-377.
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(2014).
Utilizing regulatory T cells against rheumatoid arthritis. Frontiers in Oncology.
4, 209.
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Aĝirbaşli, M. A., Song, J., Lei, F., Wang, S., Kunselman, A. R., Clark, J. B., Myers, J. L., & Ündar, A.
(2014).
Comparative effects of pulsatile and nonpulsatile flow on plasma fibrinolytic balance in pediatric patients undergoing cardiopulmonary bypass. Artif Organs.
38(1), 28-33.
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Tian, Y. i., Ni, D., Yang, W., Zhang, Y. i., Zhao, K., Song, J., ... Ni, B.
(2014).
Telbivudine treatment corrects HBV-induced epigenetic alterations in liver cells of patients with chronic hepatitis B. Carcinogenesis.
35(1), 53-61.
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Kemp, K. L., Lin, Z., Zhao, F., Gao, B., Song, J., Zhang, K., & Fang, D.
(2013).
The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells. Journal of Biological Chemistry.
288(46), 33272-33282.
-
(2013).
Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis. Mol Cell Biol.
33(15), 2810-2816.
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Lei, F., Song, J., Haque, R., Haque, M., Xiong, X., Fang, D., Croft, M., & Song, J.
(2013).
Regulation of A1 by OX40 contributes to CD8(+) T cell survival and anti-tumor activity. PLoS One.
8(8), e70635-e70635.
-
(2013).
Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. Eur J Immunol.
43(7), 1914-1924.
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(2012).
Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J Immunol.
189(3), 1228-1236.
-
(2012).
Directed differentiation of induced pluripotent stem cells towards T lymphocytes. Journal of Visualized Experiments.
e3986.
-
(2012).
USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell.
46(4), 484-494.
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(2012).
Correction: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther.
14(2), 401-401.
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(2011).
The regulation of FoxP3-expressing regulatory T cells. Endocrine Metabolic & Immune Disorders - Drug Targets.
11(4), 334-346.
-
(2011).
Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells. PLoS One.
6(11), e27770-e27770.
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(2011).
In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance. CANCER RESEARCH.
71(14), 4742-4747.
-
(2010).
FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther.
12(2), R66-R66.
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(2009).
T lineage differentiation from induced pluripotent stem cells. Cell Immunol.
260(1), 1-5.
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Zhao, B., Song, A., Haque, R., Lei, F., Weiler, L., Xiong, X., ... Song, J.
(2009).
Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. J Immunol.
182(11), 6744-6752.
-
(2008).
Intracellular signals of T cell costimulation. Cell Mol Immunol.
5(4), 239-247.
-
(2008).
Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol.
180(11), 7240-7248.
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Song, J., So, T., & Croft, M.
(2008).
Activation of NF‐kB1 by OX40 contributes to antigen‐driven T cell expansion and survival. The FASEB Journal.
22(S1), 662.5-662.5.
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Song, A., Song, J., Tang, X., & Croft, M.
(2007).
Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals. Eur J Immunol.
37(5), 1224-1232.
-
(2007).
The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nature Immunology.
8(1), 64-73.
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So, T., Song, J., Sugie, K., Altman, A., & Croft, M.
(2006).
Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proceedings of the National Academy of Sciences of USA.
103(10), 3740-3745.
-
(2005).
Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol.
175(8), 5126-5134.
-
(2005).
Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity.
22(5), 621-631.
-
(2004).
Correction: Corrigendum: The costimulation-regulated duration of PKB activation controls T cell longevity. Nature Immunology.
5(11), 1190-1190.
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Lawson, B. R., Baccala, R., Song, J., Croft, M., Kono, D. H., & Theofilopoulos, A. N.
(2004).
Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity. J Exp Med.
199(4), 547-557.
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Song, J., Salek-Ardakani, S., Rogers, P. R., Cheng, M., Van Parijs, L., & Croft, M.
(2004).
The costimulation-regulated duration of PKB activation controls T cell longevity. Nature Immunology.
5(2), 150-158.
-
(2003).
OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med.
198(2), 315-324.
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Rogers, P. R., Song, J., Gramaglia, I., Killeen, N., & Croft, M.
(2001).
OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity.
15(3), 445-455.
-
(1995).
[A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi.
13(2), 117-119.
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Song, J. J.
In vivo programming tumor Ag-specific CTL
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Ballard, D. J., Peng, H., Das, J. K., Kumar, A., Wang, L., Ren, Y., ... Song, J.
(2021).
Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase. Frontiers in Molecular Biosciences.
8, 727863.
-
chapter
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Kumar, A., Das, J. K., Peng, H., Wang, L., Ren, Y., Xiong, X., & Song, J.
(2021).
Current development in iPSC-based therapy for autoimmune diseases. Recent Advances in iPSCs for Therapy, Volume 3.
(pp. 315-338).
Elsevier.
-
(2013).
Generation of Antigen-Specific T Lymphocytes from Induced Pluripotent Stem Cells for Adoptive Immunotherapy. Stem Cells and Cancer Stem Cells, Volume 10.
(pp. 105-121).
Springer Netherlands.
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Haque, R., Lei, F., Xiong, X., & Song, J.
(2012).
Stem Cell-Based Cellular Therapy in Rheumatoid Arthritis. Autoimmune Diseases - Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies.
InTech.
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Kumar, A., Das, J. K., Peng, H., Wang, L., Ren, Y., Xiong, X., & Song, J.
(2021).
Current development in iPSC-based therapy for autoimmune diseases. Recent Advances in iPSCs for Therapy, Volume 3.
(pp. 315-338).
Elsevier.
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conference paper
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de Figueiredo, P., Guo, F., Das, J., Ding, Y., Jayaraman, A., Alaniz, R. C., & Song, J.
(2021).
A metabolically engineered bacterial vaccine protects against arthritis in mice. J Immunol.
-
Das, J. K., & Song, J.
(2019).
Regulation of CD8(+)T-lymphocytes by eEF-2K. J Immunol.
-
(2016).
Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proceedings of the National Academy of Sciences of USA.
10394-10399.
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de Figueiredo, P., Guo, F., Das, J., Ding, Y., Jayaraman, A., Alaniz, R. C., & Song, J.
(2021).
A metabolically engineered bacterial vaccine protects against arthritis in mice. J Immunol.
Research
principal investigator on
- Role of Stem Cell-Derived T Lymphocytes in Chronic HBV Infection awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2019
- Stem cell-derived regulatory T cells for therapeutic use in arthritis awarded by National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States)
co-principal investigator on
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BIOT684 Directed Prof Internship Instructor
- BIOT685 Directed Studies Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Immunology, Third Military Medical University - (Chongqing, China) 1998
- La Jolla Institute For Allergy & Immunology - (San Diego, California, United States) , Postdoctoral Training 2004
Contact
first name
- Jianxun
has last name
- Song
mailing address
-
8447 Riverside Pkwy, MREB 2, Room 3344
1359 TAMU
Bryan, TEXAS 77807
USA
Other
- JUS35@TAMU.EDU