selected publications academic article Ballard, D. J., Peng, H., Das, J. K., Kumar, A., Wang, L., Ren, Y., ... Song, J. (2021). Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase. Frontiers in Molecular Biosciences. 8, 727863. Wang, L., Das, J. K., Kumar, A., Peng, H., Ren, Y., Xiong, X., Yang, J., & Song, J. (2021). Autophagy in T-cell differentiation, survival and memory. Immunology and Cell Biology. 99(4), 351-360. Haque, M., Lei, F., Xiong, X., Ren, Y., Peng, H., Wang, L., ... Song, J. (2021). Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HIV Replication and PD-1 Expression on CD4+ T Cells. Viruses. 13(5), 753-753. Haque, M., Xiong, X., Lei, F., Das, J. K., & Song, J. (2021). An optimized protocol for the generation of HBV viral antigen-specific T lymphocytes from pluripotent stem cells. STAR Protocols. 2(1), 100264-100264. Peng, H., Lucavs, J., Ballard, D., Das, J. K., Kumar, A., Wang, L., ... Song, J. (2021). Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity. Front Immunol. 12, 652687. Fan, J., Das, J. K., Xiong, X., Chen, H., & Song, J. (2021). Development of CAR-T Cell Persistence in Adoptive Immunotherapy of Solid Tumors. Frontiers in Oncology. 10, 574860. Fan, J., Wang, M., Chen, H., Shang, D., Das, J. K., & Song, J. (2020). Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma. Molecular Cancer. 19(1), 32. Haque, M., Lei, F., Xiong, X., Ren, Y., Kumar, A., Das, J. K., ... Song, J. (2020). Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HBV Replication through Production of IFN-γ and TNF-⍺. iScience. 23(7), 101333-101333. Xuan, X., Zhou, J., Tian, Z., Lin, Y., Song, J., Ruan, Z., ... Yang, W. (2020). ILC3 cells promote the proliferation and invasion of pancreatic cancer cells through IL-22/AKT signaling. Clinical and Translational Oncology. 22(4), 563-575. Das, J. K., Xiong, X., Ren, X., Yang, J., & Song, J. (2019). Heat Shock Proteins in Cancer Immunotherapy. Journal of Oncology. 2019, 3267207-9. Yang, P., Huang, X., Lai, C., Li, L., Li, T., Huang, P., ... Zhang, S. (2019). SET domain containing 1B gene is mutated in primary hepatic neuroendocrine tumors. INTERNATIONAL JOURNAL OF CANCER. 145(11), 2986-2995. (2019). Generation of Tumor Antigen-Specific Cytotoxic T Lymphocytes from Pluripotent Stem Cells. Methods Mol Biol. 1884, 43-55. Haque, M., Das, J. K., Xiong, X., & Song, J. (2019). Targeting Stem Cell-Derived Tissue-Associated Regulatory T Cells for Type 1 Diabetes Immunotherapy. Current Diabetes Reports. 19(10), 89. Xiong, X., Lei, F., Haque, M., & Song, J. (2019). Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice. Journal of Visualized Experiments. Chen, X., Lei, F., Wang, L., Xiong, X., & Song, J. (2019). In Vitro Differentiation of T Cells from Murine Pluripotent Stem Cells. Methods Mol Biol. 2048, 131-141. Wang, X., Ji, C., Zhang, H., Shan, Y. u., Ren, Y., Hu, Y., ... Zhang, Y. i. (2019). Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. Journal of Biological Chemistry. 294(25), 10006-10017. Haque, M., Lei, F., Xiong, X., Das, J. K., Ren, X., Fang, D., ... Song, J. (2019). Stem cell-derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes. JCI INSIGHT. 4(7), (2018). Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?. Theranostics. 8(20), 5784-5800. Yang, Y. i., Kong, S., Zhang, Y., Melo-Cardenas, J., Gao, B., Zhang, Y., ... Fang, D. (2018). The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice. Journal of Biological Chemistry. 293(33), 12934-12944. Xiong, X., Das, J. K., Song, J., Ni, B., Ren, X., Yang, J., & Song, J. (2018). Protective Cancer Vaccine Using Genetically Modified Hematopoietic Stem Cells. Vaccines. 6(3), 40-40. Desai, P., Tahiliani, V., Hutchinson, T. E., Dastmalchi, F., Stanfield, J., Abboud, G., ... Salek-Ardakani, S. (2018). The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection. J Immunol. 200(8), 2894-2904. Ji, C., Xu, Q., Guo, L., Wang, X., Ren, Y., Zhang, H., ... Zhang, Y. i. (2018). eEF-2 Kinase-targeted miR-449b confers radiation sensitivity to cancer cells. CANCER LETTERS. 418, 64-74. (2017). HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity. J Immunol. 199(8), 2968-2975. Zhang, Y., Ren, Y., Guo, L., Ji, C., Hu, J., Zhang, H., ... Yang, J. (2017). Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis. Oncogene. 36(29), 4171-4181. (2017). Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells. OncoImmunology. 6(7), e1334027-e1334027. Jia, H., Truica, C. I., Wang, B., Wang, Y., Ren, X., Harvey, H. A., Song, J., & Yang, J. (2017). Immunotherapy for triple-negative breast cancer: Existing challenges and exciting prospects. Drug Resistance Updates. 32, 1-15. (2017). The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation. J Immunol. 198(10), 3927-3938. (2017). Hepatitis B Virus Immunopathology, Model Systems, and Current Therapies. Front Immunol. 8(APR), 436. (2017). c-Myc-Induced Survivin Is Essential for Promoting the Notch-Dependent T Cell Differentiation from Hematopoietic Stem Cells. Genes. 8(3), 97-97. (2016). Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity. Journal of Visualized Experiments. 2016(117), (2016). The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. NATURE COMMUNICATIONS. 7(1), 12073. (2016). Development of Auto Antigen-specific Regulatory T Cells for Diabetes Immunotherapy. Immune Network. 16(5), 281-285. (2016). Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases. International Reviews of Immunology. 35(5), 399-414. (2016). Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity. Scientific Reports. 6(1), 20588. (2016). Innate lymphoid cells as novel regulators of obesity and its-associated metabolic dysfunction. Obesity Reviews. 17(6), 485-498. Song, J. (2016). Stem Cell-Derived Regulatory T Cells for Therapeutic Use in Arthritis. Autoimmune and Infectious Diseases Open Access. 2(3), 10.16966/2470-10.161025.119. Haque, M., Song, J., Fino, K., Sandhu, P., Wang, Y., Ni, B., Fang, D., & Song, J. (2016). Melanoma Immunotherapy in Mice Using Genetically Engineered Pluripotent Stem Cells. CELL TRANSPLANTATION. 25(5), 811-827. Xu, A., Liu, Y. a., Chen, W., Wang, J., Xue, Y., Huang, F., ... Zheng, S. G (2016). TGF-β-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism. J Immunol. 196(9), 3631-3641. (2016). C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. Open Biol. 6(1), 150208-150208. Ündar, A., Wang, S., Palanzo, D. A., Wise, R. K., Woitas, K., Baer, L. D., ... Myers, J. L. (2016). Impact of Pulsatile Flow on Vital Organ Recovery During Cardiopulmonary Bypass in Neonates and Infants. Artif Organs. 40(1), 14-18. Haque, M., Fino, K., & Song, J. (2015). Stem cell-derived tissue- associated regulatory T cells ameliorate the development of autoimmune arthritis. J Immunother Cancer. 3(S2), p21-p21. (2015). Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKα Phosphorylation. J Immunol. 195(8), 3685-3693. Wang, S., Krawiec, C., Patel, S., Kunselman, A. R., Song, J., Lei, F., Baer, L. D., & Ündar, A. (2015). Laboratory Evaluation of Hemolysis and Systemic Inflammatory Response in Neonatal Nonpulsatile and Pulsatile Extracorporeal Life Support Systems. Artif Organs. 39(9), 774-781. Aĝirbaşli, M., Song, J., Lei, F., Wang, S., Kunselman, A. R., Clark, J. B., Myers, J. L., & Ündar, A. (2015). Apolipoprotein E levels in pediatric patients undergoing cardiopulmonary bypass. Artif Organs. 39(1), 28-33. (2014). Modulation of autoimmune diseases by iPS cells. Methods Mol Biol. 1213, 365-377. (2014). Utilizing regulatory T cells against rheumatoid arthritis. Frontiers in Oncology. 4, 209. Aĝirbaşli, M. A., Song, J., Lei, F., Wang, S., Kunselman, A. R., Clark, J. B., Myers, J. L., & Ündar, A. (2014). Comparative effects of pulsatile and nonpulsatile flow on plasma fibrinolytic balance in pediatric patients undergoing cardiopulmonary bypass. Artif Organs. 38(1), 28-33. Tian, Y. i., Ni, D., Yang, W., Zhang, Y. i., Zhao, K., Song, J., ... Ni, B. (2014). Telbivudine treatment corrects HBV-induced epigenetic alterations in liver cells of patients with chronic hepatitis B. Carcinogenesis. 35(1), 53-61. Kemp, K. L., Lin, Z., Zhao, F., Gao, B., Song, J., Zhang, K., & Fang, D. (2013). The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells. Journal of Biological Chemistry. 288(46), 33272-33282. (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis. Mol Cell Biol. 33(15), 2810-2816. Lei, F., Song, J., Haque, R., Haque, M., Xiong, X., Fang, D., Croft, M., & Song, J. (2013). Regulation of A1 by OX40 contributes to CD8(+) T cell survival and anti-tumor activity. PLoS One. 8(8), e70635-e70635. (2013). Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. Eur J Immunol. 43(7), 1914-1924. (2012). Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J Immunol. 189(3), 1228-1236. (2012). Directed differentiation of induced pluripotent stem cells towards T lymphocytes. Journal of Visualized Experiments. e3986. (2012). USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell. 46(4), 484-494. (2012). Correction: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther. 14(2), 401-401. (2011). The regulation of FoxP3-expressing regulatory T cells. Endocrine Metabolic & Immune Disorders - Drug Targets. 11(4), 334-346. (2011). Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells. PLoS One. 6(11), e27770-e27770. (2011). In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance. CANCER RESEARCH. 71(14), 4742-4747. (2010). FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther. 12(2), R66-R66. (2009). T lineage differentiation from induced pluripotent stem cells. Cell Immunol. 260(1), 1-5. Zhao, B., Song, A., Haque, R., Lei, F., Weiler, L., Xiong, X., ... Song, J. (2009). Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. J Immunol. 182(11), 6744-6752. (2008). Intracellular signals of T cell costimulation. Cell Mol Immunol. 5(4), 239-247. (2008). Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol. 180(11), 7240-7248. Song, J., So, T., & Croft, M. (2008). Activation of NF‐kB1 by OX40 contributes to antigen‐driven T cell expansion and survival. The FASEB Journal. 22(S1), 662.5-662.5. Song, A., Song, J., Tang, X., & Croft, M. (2007). Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals. Eur J Immunol. 37(5), 1224-1232. (2007). The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nature Immunology. 8(1), 64-73. So, T., Song, J., Sugie, K., Altman, A., & Croft, M. (2006). Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proceedings of the National Academy of Sciences of USA. 103(10), 3740-3745. (2005). Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol. 175(8), 5126-5134. (2005). Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity. 22(5), 621-631. (2004). Correction: Corrigendum: The costimulation-regulated duration of PKB activation controls T cell longevity. Nature Immunology. 5(11), 1190-1190. Lawson, B. R., Baccala, R., Song, J., Croft, M., Kono, D. H., & Theofilopoulos, A. N. (2004). Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity. J Exp Med. 199(4), 547-557. Song, J., Salek-Ardakani, S., Rogers, P. R., Cheng, M., Van Parijs, L., & Croft, M. (2004). The costimulation-regulated duration of PKB activation controls T cell longevity. Nature Immunology. 5(2), 150-158. (2003). OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med. 198(2), 315-324. Rogers, P. R., Song, J., Gramaglia, I., Killeen, N., & Croft, M. (2001). OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 15(3), 445-455. (1995). [A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 13(2), 117-119. Song, J. J. In vivo programming tumor Ag-specific CTL chapter Kumar, A., Das, J. K., Peng, H., Wang, L., Ren, Y., Xiong, X., & Song, J. (2021). Current development in iPSC-based therapy for autoimmune diseases. Recent Advances in iPSCs for Therapy, Volume 3. (pp. 315-338). Elsevier. (2013). Generation of Antigen-Specific T Lymphocytes from Induced Pluripotent Stem Cells for Adoptive Immunotherapy. Stem Cells and Cancer Stem Cells, Volume 10. (pp. 105-121). Springer Netherlands. Haque, R., Lei, F., Xiong, X., & Song, J. (2012). Stem Cell-Based Cellular Therapy in Rheumatoid Arthritis. Autoimmune Diseases - Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies. InTech. conference paper de Figueiredo, P., Guo, F., Das, J., Ding, Y., Jayaraman, A., Alaniz, R. C., & Song, J. (2021). A metabolically engineered bacterial vaccine protects against arthritis in mice. J Immunol. Das, J. K., & Song, J. (2019). Regulation of CD8(+)T-lymphocytes by eEF-2K. J Immunol. (2016). Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proceedings of the National Academy of Sciences of USA. 10394-10399.
principal investigator on Role of Stem Cell-Derived T Lymphocytes in Chronic HBV Infection awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2019 Stem cell-derived regulatory T cells for therapeutic use in arthritis awarded by National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States)
co-principal investigator on Nucleus accumbens-associated protein-1 in melanoma immunotherapy awarded by National Cancer Institute - (Rockville, Maryland, United States)
teaching activities BICH491 Hnr-research Instructor BIOT684 Directed Prof Internship Instructor BIOT685 Directed Studies Instructor MSCI691 Research Credit: Medical Sci Instructor
education and training Ph.D. in Immunology, Third Military Medical University - (Chongqing, China) 1998 La Jolla Institute For Allergy & Immunology - (San Diego, California, United States) , Postdoctoral Training 2004