In Vitro Differentiation of T Cells from Murine Pluripotent Stem Cells.
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In recent years cancer immunotherapy, especially the cell-based immunotherapy, has reached several milestones and achieved a lot of cancer remission in the clinics. Obtaining a more potent and effective cytotoxic T lymphocytes (CTLs) for cancer immunotherapy is always the ultimate goal for the researchers. However, the difficulty in harvesting a large number of tumor antigen-specific CTLs from the tumor patient is still a major obstacle we need to overcome. In our previous studies, it is shown that pluripotent stem cell-derived CTL-especially the genetically engineered antigen-specific CTLs-may serve as a good source of unlimited number of highly reactive and antigen-specific CTLs. Here we present a two-step method for the generation of antigen-specific T lymphocytes from iPS cells by in vitro priming and in vivo maturation.
author list (cited authors)
Chen, X., Lei, F., Wang, L., Xiong, X., & Song, J.
complete list of authors
Chen, Xiaoniao||Lei, Fengyang||Wang, Liqiang||Xiong, Xiaofang||Song, Jianxun