Regulation of c-Myc/survivin from notch signaling modulates T cell differentiation (HEM2P.250) Academic Article uri icon


  • Abstract Notch signaling is essential for T cell lineage commitment and is further required during early phases of thymocyte differentiation. Active Notch signaling during these early stages of T cell development inhibits other lineage potentials, such as B cell and myeloid cell (e.g., dendritic cell) potential. However, the intracellular signaling pathways by which Notch signaling regulates T cell differentiation remain unknown. Here we show that the transcriptional factor c-Myc is controlled by Notch signaling which regulates T cell differentiation. In a well-established in vitro differentiation of T lymphocytes from stem cells, Notch signaling directly controls c-Myc expression. Overexpression of active c-Myc promotes while dominant-negative (dn) c-Myc inhibits early cell differentiation. Moreover, c-Myc expression mediated by Notch signaling modulates survivin, an inhibitor of apoptosis (IAP) protein, which is crucial for T cell development. Overexpression of active c-Myc increases while dn c-Myc reduces survivin expression, which is correlated with T cell differentiation within the in vitro differentiation system. These data identify c-Myc, together with survivin, as regulators of the differentiation of T cells from Notch signaling.

published proceedings

  • The Journal of Immunology

author list (cited authors)

  • Song, J., Fino, K., & Haque, M.

citation count

  • 0

complete list of authors

  • Song, Jianxun||Fino, Krisitn||Haque, Mohammad

publication date

  • May 2015