OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Academic Article

abstract

• It is important to understand which molecules are essential for long-lived immunity. We show that OX40 (CD134) is required with CD28 for the survival of CD4 T cells following antigen-driven expansion. In contrast to CD28-/- T cells, which show defects early, OX40-/- T cells are relatively unimpaired in IL-2 production, cell division, and expansion. However, OX40-/- T cells fail to maintain high levels of Bcl-xL and Bcl-2 4-8 days after activation, and undergo apoptosis. Conversely, OX40 stimulation promotes Bcl-xL and Bcl-2 and suppresses apoptosis. Moreover, retroviral transduction of OX40-/- T cells with Bcl-xL or Bcl-2 reverses their survival defect. Thus, a temporal relationship exists between CD28 and OX40, with OX40 being a critical regulator of antigen-driven T cell survival.

authors

• Song, Jianxun

published proceedings

• Immunity

altmetric score

• 15

author list (cited authors)

• Rogers, P. R., Song, J., Gramaglia, I., Killeen, N., & Croft, M.

citation count

• 523

complete list of authors

• Rogers, PR||Song, J||Gramaglia, I||Killeen, N||Croft, M

publication date

• January 2001

publisher

• Elsevier  Publisher

published in

• Immunity  Journal

keywords

• Animals
• Apoptosis
• Bcl-X Protein
• CD4-Positive T-Lymphocytes
• Cd28 Antigens
• Cell Survival
• Cells, Cultured
• Membrane Glycoproteins
• Mice
• Mice, Transgenic
• Ox40 Ligand
• Proto-Oncogene Proteins C-bcl-2
• Receptors, Ox40
• Receptors, Tumor Necrosis Factor
• Retroviridae
• Tumor Necrosis Factor Receptor Superfamily, Member 7
• Tumor Necrosis Factors

Digital Object Identifier (DOI)

• 10.1016/s1074-7613(01)00191-1

start page

• 445

end page

• 455

volume

• 15

issue

• 3

URL

• http://dx.doi.org/10.1016/s1074-7613(01)00191-1