Modulation of autoimmune diseases by iPS cells. Academic Article

abstract

• Autoimmune disease is typically caused by the activated self-reacted immune cells. The mainstream treatment to autoimmune disorders is composed of different mechanisms of immunosuppression. In recent years, a new subtype of T cells called regulatory T (Treg) cells have been identified to maintain the immune homeostasis in terms of suppressing the activated immune components. According to this discovery, it is suggested that treating autoimmune patients by supplementing Treg cells would be a good choice. However, due to their natural scarcity, it is difficult to isolate a desired number of Treg for this therapeutical approach. Here, we report that by using stem cells, especially the induced pluripotent stem (iPS) cells, we are able to generate a significant amount of Treg cells for the autoimmune prevention and treatment.

authors

• Song, Jianxun

published proceedings

• Methods Mol Biol

altmetric score

• 0.25

author list (cited authors)

• Lei, F., Haque, R., Xiong, X., & Song, J.

citation count

• 2

complete list of authors

• Lei, Fengyang||Haque, Rizwanul||Xiong, Xiaofang||Song, Jianxun

publication date

• January 2014

publisher

• Springer Nature  Publisher

published in

• Methods in molecular biology (Clifton, N.J.)  Journal

keywords

• Adoptive Transfer
• Animals
• Arthritis, Experimental
• Autoimmune Diseases
• Cell Differentiation
• Cell Line
• Disease Models, Animal
• Flow Cytometry
• Fluorescent Antibody Technique
• Forkhead Transcription Factors
• Gene Expression
• Genetic Vectors
• Immune Tolerance
• Immunohistochemistry
• Immunomodulation
• Immunophenotyping
• Induced Pluripotent Stem Cells
• Male
• Mice
• Retroviridae
• Transduction, Genetic

PubMed Central ID

• 25173398

Digital Object Identifier (DOI)

• 10.1007/978-1-4939-1453-1_30

start page

• 365

end page

• 377

volume

• 1213

URL

• http://dx.doi.org/10.1007/978-1-4939-1453-1_30