C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. Academic Article uri icon


  • The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8(+) T cells is controlled by costimulatory molecules, which modulates the development of memory CD8(+) T cells. C-Myc expression was dramatically reduced in Cd28(-/-) or Ox40(-/-) memory CD8(+) T cells, and c-Myc over-expression substantially reversed the defects in the development of T-cell memory following viral infection. C-Myc regulated the expression of survivin, an inhibitor of apoptosis, which promoted the generation of virus-specific memory CD8(+) T cells. Moreover, over-expression of survivin with bcl-xL, a downstream molecule of NF-B and intracellular target of costimulation that controls survival, in Cd28(-/-) or Ox40(-/-) CD8(+) T cells, reversed the defects in the generation of memory T cells in response to viral infection. These results identify c-Myc as a key controller of memory CD8(+) T cells from costimulatory signals.

published proceedings

  • Open Biol

author list (cited authors)

  • Haque, M., Song, J., Fino, K., Wang, Y., Sandhu, P., Song, X., ... Song, J.

citation count

  • 18

complete list of authors

  • Haque, Mohammad||Song, Jianyong||Fino, Kristin||Wang, Youfei||Sandhu, Praneet||Song, Xinmeng||Norbury, Christopher||Ni, Bing||Fang, Deyu||Salek-Ardakani, Shahram||Song, Jianxun

publication date

  • January 2016