Autophagy in T-cell differentiation, survival and memory. Academic Article

abstract

• Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.

authors

• Song, Jianxun

published proceedings

• Immunol Cell Biol

altmetric score

• 1

author list (cited authors)

• Wang, L., Das, J. K., Kumar, A., Peng, H., Ren, Y., Xiong, X., Yang, J., & Song, J.

citation count

• 6

complete list of authors

• Wang, Liqing||Das, Jugal Kishore||Kumar, Anil||Peng, Hao-Yun||Ren, Yijie||Xiong, Xiaofang||Yang, Jin-Ming||Song, Jianxun

publication date

• April 2021

publisher

• Wiley  Publisher

published in

• Immunology and Cell Biology  Journal

keywords

• Autophagy
• Cell Differentiation
• Differentiation
• Immunotherapy
• Lymphocyte Activation
• Memory
• Survival
• T Cells.
• T-Lymphocyte Subsets

PubMed Central ID

• 33141986

Digital Object Identifier (DOI)

• 10.1111/imcb.12422

start page

• 351

end page

• 360

volume

• 99

issue

• 4

URL

• http://dx.doi.org/10.1111/imcb.12422