Autophagy in T-cell differentiation, survival and memory. Academic Article uri icon


  • Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.

published proceedings

  • Immunol Cell Biol

altmetric score

  • 1

author list (cited authors)

  • Wang, L., Das, J. K., Kumar, A., Peng, H., Ren, Y., Xiong, X., Yang, J., & Song, J.

citation count

  • 6

complete list of authors

  • Wang, Liqing||Das, Jugal Kishore||Kumar, Anil||Peng, Hao-Yun||Ren, Yijie||Xiong, Xiaofang||Yang, Jin-Ming||Song, Jianxun

publication date

  • April 2021