T lineage differentiation from induced pluripotent stem cells. Academic Article

abstract

• Induced pluripotent stem (iPS) cells have potential to differentiate into T lymphocytes, however, the actual ability of iPS cells to develop into T lineages is not clear. In this study, we co-cultured iPS cells on OP9 cells expressing the Notch ligand Delta-like 1 (DL1), the iPS cells differentiated into T lymphocytes. In addition, in vitro stimulation of iPS cell-derived T lymphocytes resulted in secretion of IL-2 and IFN-gamma. Moreover, adoptive transfer of iPS cell-derived T lymphocytes into Rag-deficient mice reconstituted their T cell pools. These results indicate that iPS cells are able to follow the normal program of T cell differentiation.

authors

• Song, Jianxun

published proceedings

• Cell Immunol

altmetric score

• 9

author list (cited authors)

• Lei, F., Haque, R., Weiler, L., Vrana, K. E., & Song, J.

citation count

• 43

publication date

• October 2009

publisher

• Elsevier  Publisher

keywords

• Animals
• Antigens, CD
• Cell Differentiation
• Cell Lineage
• Mice
• Pluripotent Stem Cells
• Receptors, Notch
• T-Lymphocyte Subsets
• T-Lymphocytes

PubMed Central ID

• 19811778

Digital Object Identifier (DOI)

• 10.1016/j.cellimm.2009.09.005

start page

• 1

end page

• 5

volume

• 260

issue

• 1

URL

• http://dx.doi.org/10.1016/j.cellimm.2009.09.005