T lineage differentiation from induced pluripotent stem cells. Academic Article uri icon


  • Induced pluripotent stem (iPS) cells have potential to differentiate into T lymphocytes, however, the actual ability of iPS cells to develop into T lineages is not clear. In this study, we co-cultured iPS cells on OP9 cells expressing the Notch ligand Delta-like 1 (DL1), the iPS cells differentiated into T lymphocytes. In addition, in vitro stimulation of iPS cell-derived T lymphocytes resulted in secretion of IL-2 and IFN-gamma. Moreover, adoptive transfer of iPS cell-derived T lymphocytes into Rag-deficient mice reconstituted their T cell pools. These results indicate that iPS cells are able to follow the normal program of T cell differentiation.

published proceedings

  • Cell Immunol

altmetric score

  • 9

author list (cited authors)

  • Lei, F., Haque, R., Weiler, L., Vrana, K. E., & Song, J.

citation count

  • 43

publication date

  • October 2009