T Cell Response to SARS-CoV-2 Coinfection and Comorbidities. Academic Article uri icon


  • For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses are also impacted by many other pathogens and chronic diseases. We have summarized T cell performance during SARS-CoV-2 coinfection with other viruses, bacteria, and parasites. Furthermore, we distinguished if those altered T cell statuses under coinfection would affect their clinical outcomes, such as symptom severity and hospitalization demand. T cell alteration in diabetes, asthma, and hypertension patients with SARS-CoV-2 infection was also investigated in our study. We have summarized whether changes in T cell response influence the clinical outcome during comorbidities.

published proceedings

  • Pathogens

altmetric score

  • 4.25

author list (cited authors)

  • Wang, L., Peng, H., Pham, A., Villazana, E., Ballard, D. J., Das, J. K., ... Song, J.

citation count

  • 1

publication date

  • February 2023