Generation of Antigen-Specific T Lymphocytes from Induced Pluripotent Stem Cells for Adoptive Immunotherapy Chapter uri icon

abstract

  • Springer Science+Business Media Dordrecht 2013. Conquering cancer, one of the leading human health problems, is a major task for both basic and clinical scientists. With the understanding of recently developed cancer immunotherapy, in particular the cytotoxic T lymphocyte (CTL)-mediated immunotherapy, T cell development as well as the applications of stem cell technologies, an individualized cancer immunotherapy could be promisingly designed by avoiding several main obstacles in obtaining a large number of autologous and highlyreactive tumor-specific CTLs. Through induced pluripotent stem (iPS) cell technologies, tumor-specific CTLs could be generated from a piece of skin or blood from the individual cancer patient, following genetic modification as well as a directed differentiation. This novel approach could potentially further expand the weaponry to battle cancer.

author list (cited authors)

  • Lei, F., Haque, R., Xiong, X., & Song, J.

complete list of authors

  • Lei, Fengyang||Haque, Rizwanul||Xiong, Xiaofang||Song, Jianxun

Book Title

  • Stem Cells and Cancer Stem Cells, Volume 10

publication date

  • January 1, 2013 11:11 AM