Stem Cell-Derived Regulatory T Cells for Therapeutic Use in Arthritis. Academic Article uri icon

abstract

  • Pluripotent stem cells (PSCs) can be utilized to obtain a renewable source of healthy regulatory T cells (Tregs) to treat autoimmune arthritis as they have the ability to produce almost all cell types in the body, including Tregs. However, the right conditions for the development of antigen (Ag)-specific Tregs from PSCs (i.e., PSC-Tregs) remain unknown. An ongoing project will determine the mechanisms underlying the Ag-specific PSC-Treg treatments that aim to modulate tolerance in autoimmune arthritis. The knowledge gained from these studies will provide new insights into cell-based therapies in autoimmune arthritis, and advance the understanding of fundamental mechanisms underlying Treg differentiation.

published proceedings

  • Autoimmune Infect Dis

author list (cited authors)

  • Song, J.

citation count

  • 1

complete list of authors

  • Song, Jianxun

publication date

  • January 1, 2016 11:11 AM