HR job title
- Professor
- Contact Info
- Websites
- ORCiD
- 0000-0001-8574-1251
Lele, Tanmay Professor
Positions
- Professor, Biomedical Engineering, College of Engineering
Dr. Tanmay Lele's research is in the area of mechanobiology with a focus on cancer mechanobiology. His lab is interested in the molecular mechanisms by which cell generated mechanical forces and associated signaling pathways enable cell and tissue functions, and how these relationships become altered in cancer. Current research projects in the laboratory include quantitative measurements of nuclear forces, the effect of mechanical stresses on nuclear functions and gene expression, cellular adaptation to mechanical properties of the extracellular matrix, and the mechanics of cancer tissue development.
Lele is a scholar in cancer research at the Cancer Prevention and Research Institute of Texas.
Lele is a scholar in cancer research at the Cancer Prevention and Research Institute of Texas.
Research Areas
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- Research
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Overview
Publications
selected publications
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academic article
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Scott, K. L., Halfmann, C. T., Hoefakker, A. D., Purkayastha, P., Wang, T. C., Lele, T. P., & Roux, K. J.
(2024).
Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability. Journal of Cell Biology.
223(7), e202308152.
-
Mukhopadhyay, S., Bishayi, R., Shaji, A., Lee, A. H., Gupta, R., Mohajeri, M., ... Lele, P. P.
(2024).
Dynamic Adaptation in Extant Porins Facilitates Antibiotic Tolerance in Energetic Escherichia coli
-
Dickinson, R. B., & Lele, T. P.
(2023).
A new function for nuclear lamins: Providing surface tension to the nuclear drop. Current Opinion in Biomedical Engineering.
28, 100483-100483.
-
Lee, H., Cai, K. X., Wang, T., Davis, R., Deo, K., Singh, K. A., Lele, T. P., & Gaharwar, A. K.
(2023).
Dynamically crosslinked thermoresponsive granular hydrogels. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.
111(10), 1577-1587.
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Narayanan, V., Purkayastha, P., Yu, B. o., Pendyala, K., Chukkapalli, S., Cabe, J. I., ... Lele, T. P.
(2023).
Rho activation drives luminal collapse and eversion in epithelial acini. 122(18), 3630-3645.
-
Lee, H., Davis, R., Wang, T., Deo, K. A., Cai, K. X., Alge, D. L., Lele, T. P., & Gaharwar, A. K.
(2023).
Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery. ACS Applied Bio Materials.
6(9), 3683-3695.
-
Purushothaman, A., Mohajeri, M., & Lele, T. P.
(2023).
The role of glycans in the mechanobiology of cancer. 299(3), 102935-102935.
-
Dickinson, R. B., & Lele, T. P.
(2023).
Nuclear shapes are geometrically determined by lamina excess area. 122(3), 535A-535A.
-
Lele, T. P., Levy, D. L., & Mishra, K.
(2023).
Editorial: Nuclear morphology in development and disease. Frontiers in Cell and Developmental Biology.
11, 1267645.
-
Taubenberger, A. V., & Lele, T. P.
(2023).
Introduction to soft matter aspects of cancer. SOFT MATTER.
19(4), 586-587.
-
Dickinson, R. B., & Lele, T. P.
(2023).
Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina. Frontiers in Cell and Developmental Biology.
11, 1058727.
-
Jones, M. L., Dahl, K. N., Lele, T. P., Conway, D. E., Shenoy, V., Ghosh, S., & Szczesny, S. E.
(2022).
The Elephant in the Cell: Nuclear Mechanics and Mechanobiology. Journal of Biomechanical Engineering.
144(8), 080802.
-
Katiyar, A., Zhang, J., Antani, J. D., Yu, Y., Scott, K. L., Lele, P. P., ... Lele, T. P.
(2022).
The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C. Advanced Science.
9(23), e2201248-2201248.
-
Atanasova, K. R., Chakraborty, S., Ratnayake, R., Khare, K. D., Luesch, H., & Lele, T. P.
(2022).
An epigenetic small molecule screen to target abnormal nuclear morphology in human cells. 33(6), ar45.
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Dickinson, R. B., Katiyar, A., Dubell, C. R., & Lele, T. P.
(2022).
Viscous shaping of the compliant cell nucleus. APL Bioengineering.
6(1), 010901-010901.
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Ellison, S. T., Duraivel, S., Subramaniam, V., Hugosson, F., Yu, B. o., Lebowitz, J. J., ... Angelini, T. E.
(2022).
Cellular micromasonry: biofabrication with single cell precision. SOFT MATTER.
18(45), 8554-8560.
-
Singh, I., & Lele, T. P.
(2022).
Nuclear Morphological Abnormalities in Cancer: A Search for Unifying Mechanisms. 70, 443-467.
-
Tamashunas, A. C., Katiyar, A., Zhang, Q., Purkayastha, P., Singh, P. K., Chukkapalli, S. S., & Lele, T. P.
(2021).
Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts. Journal of Cellular Physiology.
236(8), 5715-5724.
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Purkayastha, P., Pendyala, K., Saxena, A. S., Hakimjavadi, H., Chamala, S., Dixit, P., Baer, C. F., & Lele, T. P.
(2021).
Reverse Plasticity Underlies Rapid Evolution by Clonal Selection within Populations of Fibroblasts Propagated on a Novel Soft Substrate. Molecular Biology and Evolution (MBE).
38(8), 3279-3293.
-
Purkayastha, P., Jaiswal, M. K., & Lele, T. P.
(2021).
Molecular cancer cell responses to solid compressive stress and interstitial fluid pressure. 78(6), 312-322.
-
Lele, T.
(2021).
Nuclear mechanics in migrating cells. The FASEB Journal.
35(S1),
-
Katiyar, A., Antani, J. D., McKee, B. P., Gupta, R., Lele, P. P., & Lele, T. P.
(2021).
A method for direct imaging of x-z cross-sections of fluorescent samples. Journal of Microscopy.
281(3), 224-230.
-
Antani, J. D., Sumali, A. X., Lele, T. P., & Lele, P. P.
(2021).
Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias in Helicobacter pylori. eLife.
10, e63936.
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O'Bryan, C. S., Zhang, Q., Lele, T. P., & Angelini, T. E.
(2020).
Mechanical Characterization of Glandular Acini Using a Micro-indentation Instrument. Bio-protocol.
10(23), e3847.
-
Chamala, S., Flax, S., Starostik, P., Cherabuddi, K., Iovine, N. M., Majety, S., ... Clare-Salzler, M. J.
(2020).
Optimizing COVID-19 testing capabilities and clinical management using pathology informatics. JAMIA Open.
3(4), 523-529.
-
Agrawal, A., & Lele, T. P.
(2020).
Geometry of the nuclear envelope determines its flexural stiffness. Molecular Biology of the Cell.
31(16), 1815-1821.
-
Lele, T. P., Brock, A., & Peyton, S. R.
(2020).
Emerging Concepts and Tools in Cell Mechanomemory. Annals of Biomedical Engineering.
48(7), 2103-2112.
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Tamashunas, A. C., Tocco, V. J., Matthews, J., Zhang, Q., Atanasova, K. R., Paschall, L., ... Lele, T. P.
(2020).
High-throughput gene screen reveals modulators of nuclear shape. Molecular Biology of the Cell.
31(13), 1392-1402.
-
Lele, T.
(2020).
Nuclear mechanics in migrating cells. 34(S1), 1-1.
-
Chawla, R., Gupta, R., Lele, T. P., & Lele, P. P.
(2020).
A Skeptic's Guide to Bacterial Mechanosensing. Journal of Molecular Biology.
432(2), 523-533.
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Katiyar, A., Tocco, V. J., Li, Y., Aggarwal, V., Tamashunas, A. C., Dickinson, R. B., & Lele, T. P.
(2019).
Nuclear size changes caused by local motion of cell boundaries unfold the nuclear lamina and dilate chromatin and intranuclear bodies. SOFT MATTER.
15(45), 9310-9317.
-
Kent, I. A., Zhang, Q., Katiyar, A., Li, Y., Pathak, S., Dickinson, R. B., & Lele, T. P.
(2019).
Apical cell protrusions cause vertical deformation of the soft cancer nucleus. Journal of Cellular Physiology.
234(11), 20675-20684.
-
Bennett, R. L., Bele, A., Small, E. C., Will, C. M., Nabet, B., Oyer, J. A., ... Licht, J. D.
(2019).
A Mutation in Histone H2B Represents a New Class of Oncogenic Driver. Cancer Discovery.
9(10), 1438-1451.
-
Zhang, Q., Narayanan, V., Mui, K. L., O'Bryan, C. S., Anderson, R. H., Kc, B., ... Lele, T. P.
(2019).
Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex. Current Biology.
29(17), 2826-2839.e4.
-
Agrawal, A., & Lele, T. P.
(2019).
Mechanics of nuclear membranes. Journal of Cell Science.
132(14), jcs229245.
-
Halfmann, C. T., Sears, R. M., Katiyar, A., Busselman, B. W., Aman, L. K., Zhang, Q., ... Roux, K. J.
(2019).
Repair of nuclear ruptures requires barrier-to-autointegration factor. 218(7), 2136-2149.
-
Zhang, Q., Tamashunas, A. C., Agrawal, A., Torbati, M., Katiyar, A., Dickinson, R. B., Lammerding, J., & Lele, T. P.
(2019).
Local, transient tensile stress on the nuclear membrane causes membrane rupture. Molecular Biology of the Cell.
30(7), 899-906.
-
Lele, T. P., Dickinson, R. B., & Gundersen, G. G.
(2018).
Mechanical principles of nuclear shaping and positioning. Journal of Cell Biology.
217(10), 3330-3342.
-
Chukkapalli, S. S., & Lele, T. P.
(2018).
Periodontal cell mechanotransduction. Open Biology.
8(9), 180053-180053.
-
Zhang, Q., Tamashunas, A. C., & Lele, T. P.
(2018).
A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton. Journal of Visualized Experiments.
-
Zhang, Q., Tamashunas, A. C., & Lele, T. P.
(2018).
A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton. Journal of Visualized Experiments.
-
Tocco, V. J., Li, Y., Christopher, K. G., Matthews, J. H., Aggarwal, V., Paschall, L., ... Lele, T. P.
(2018).
The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells. Journal of Cellular Physiology.
233(2), 1446-1454.
-
Kent, I. A., & Lele, T. P.
(2017).
Microtubule-based force generation. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology.
9(3),
-
Aggarwal, V., & Lele, T. P.
(2017).
Intracellular Concentration Gradients That Mirror External Gradients in Microfluidic Flows: A Computational Analysis. Cellular and Molecular Bioengineering.
10(2), 198-207.
-
Torbati, M., Lele, T. P., & Agrawal, A.
(2017).
Ultradonut Topology of the Nuclear Envelope. Biophysical Journal.
112(3), 384A-385A.
-
Alam, S. G., Zhang, Q., Prasad, N., Li, Y., Chamala, S., Kuchibhotla, R., ... Lele, T. P.
(2016).
The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity. Scientific Reports.
6(1), 38063.
-
Torbati, M., Lele, T. P., & Agrawal, A.
(2016).
Ultradonut topology of the nuclear envelope. Proceedings of the National Academy of Sciences of the United States of America.
113(40), 11094-11099.
-
Torbati, M., Lele, T. P., & Agrawal, A.
(2016).
An unresolved LINC in the nuclear envelope. Cellular and Molecular Bioengineering.
9(2), 252-257.
-
Zhang, Q., Kota, K. P., Alam, S. G., Nickerson, J. A., Dickinson, R. B., & Lele, T. P.
(2016).
Coordinated Dynamics of RNA Splicing Speckles in the Nucleus. Journal of Cellular Physiology.
231(6), 1269-1275.
-
Neelam, S., Dickinson, R. B., & Lele, T. P.
(2016).
New approaches for understanding the nuclear force balance in living, adherent cells. Methods.
94, 27-32.
-
Aggarwal, V., Dickinson, R. B., & Lele, T. P.
(2016).
Concentration Sensing by the Moving Nucleus in Cell Fate Determination: A Computational Analysis. PLoS ONE.
11(2), e0149213-e0149213.
-
Kent, I. A., Rane, P. S., Dickinson, R. B., Ladd, A., & Lele, T. P.
(2016).
Transient Pinning and Pulling: A Mechanism for Bending Microtubules. 11(3), e0151322-e0151322.
-
Neelam, S., Hayes, P. R., Zhang, Q., Dickinson, R. B., & Lele, T. P.
(2016).
Vertical uniformity of cells and nuclei in epithelial monolayers. Scientific Reports.
6(1), 19689.
-
Dickinson, R. B., Neelam, S., & Lele, T. P.
(2015).
Dynamic, mechanical integration between nucleus and cell- where physics meets biology. Nucleus.
6(5), 360-365.
-
Li, Y., Lovett, D., Zhang, Q., Neelam, S., Kuchibhotla, R. A., Zhu, R., ... Dickinson, R. B.
(2015).
Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading. Biophysical Journal.
109(4), 670-686.
-
Dickinson, R. B., & Lele, T. P.
(2015).
Chemical Engineering Principles in the Field of Cell Mechanics. Industrial & Engineering Chemistry Research.
54(23), 6061-6066.
-
Neelam, S., Chancellor, T. J., Li, Y., Nickerson, J. A., Roux, K. J., Dickinson, R. B., & Lele, T. P.
(2015).
Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell. Proceedings of the National Academy of Sciences of the United States of America.
112(18), 5720-5725.
-
Alam, S. G., Lovett, D., Kim, D. I., Roux, K. J., Dickinson, R. B., & Lele, T. P.
(2015).
The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts. Journal of Cell Science.
128(10), 1901-1911.
-
Wu, J., Kent, I. A., Shekhar, N., Chancellor, T. J., Mendonca, A., Dickinson, R. B., & Lele, T. P.
(2014).
Actomyosin pulls to advance the nucleus in a migrating tissue cell. Biophysical Journal.
106(1), 7-15.
-
Lewis, J. S., Dolgova, N. V., Chancellor, T. J., Acharya, A. P., Karpiak, J. V., Lele, T. P., & Keselowsky, B. G.
(2013).
The effect of cyclic mechanical strain on activation of dendritic cells cultured on adhesive substrates. Biomaterials.
34(36), 9063-9070.
-
Shekhar, N., Neelam, S., Wu, J., Ladd, A. J., Dickinson, R. B., & Lele, T. P.
(2013).
FLUCTUATING MOTOR FORCES BEND GROWING MICROTUBULES. Cellular and Molecular Bioengineering.
6(2), 120-129.
-
Lovett, D. B., Shekhar, N., Nickerson, J. A., Roux, K. J., & Lele, T. P.
(2013).
Modulation of Nuclear Shape by Substrate Rigidity. Cellular and Molecular Bioengineering.
6(2), 230-238.
-
Shekhar, N., Wu, J., Dickinson, R. B., & Lele, T. P.
(2013).
Cytoplasmic dynein: tension generation on microtubules and the nucleus. Cellular and Molecular Bioengineering.
6(1), 74-81.
-
Wu, J., Shekhar, N., Lele, P. P., & Lele, T. P.
(2012).
FRAP analysis: accounting for bleaching during image capture. PLoS ONE.
7(8), e42854-e42854.
-
Chancellor, T. J., Lee, J., Thodeti, C., & Lele, T. P.
(2012).
Correction. Biophysical Journal.
102(10), 2411-2411.
-
Wu, J., Dickinson, R. B., & Lele, T. P.
(2012).
Investigation of in vivo microtubule and stress fiber mechanics with laser ablation. Integrative Biology: interdisciplinary approaches for molecular and cellular life sciences.
4(5), 471-479.
-
Wu, J., Misra, G., Russell, R. J., Ladd, A., Lele, T. P., & Dickinson, R. B.
(2011).
Effects of dynein on microtubule mechanics and centrosome positioning. Molecular Biology of the Cell.
22(24), 4834-4841.
-
Wu, J., Lee, K. C., Dickinson, R. B., & Lele, T. P.
(2011).
How dynein and microtubules rotate the nucleus. Journal of Cellular Physiology.
226(10), 2666-2674.
-
Russell, R. J., Grubbs, A. Y., Mangroo, S. P., Nakasone, S. E., Dickinson, R. B., & Lele, T. P.
(2011).
Sarcomere length fluctuations and flow in capillary endothelial cells. 68(3), 150-156.
-
Lee, J., Chu, B. H., Sen, S., Gupte, A., Chancellor, T. J., Chang, C., ... Lele, T. P.
(2011).
Modulating malignant epithelial tumor cell adhesion, migration and mechanics with nanorod surfaces. Biomedical Microdevices.
13(1), 89-95.
-
Misra, G., Ladd, A., Lele, T. P., Russel, R., Wu, J., & Dickinson, R. B.
(2011).
Cyto-Mechanics of Microtubular Buckling and Centering of Centrosome. Biophysical Journal.
100(3), 308a-308a.
-
Lee, J., Wang, Y., Ren, F., & Lele, T. P.
(2010).
Stamp wound assay for studying coupled cell migration and cell debris clearance. Langmuir.
26(22), 16672-16676.
-
Chancellor, T. J., Lee, J., Thodeti, C. K., & Lele, T.
(2010).
Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation (vol 99, pg 115, 2010). Biophysical Journal.
99(4), 1329-1329.
-
Chancellor, T. J., Lee, J., Thodeti, C. K., & Lele, T.
(2010).
Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation. Biophysical Journal.
99(1), 115-123.
-
Zaveri, T. D., Dolgova, N. V., Chu, B. H., Lee, J., Wong, J., Lele, T. P., Ren, F., & Keselowsky, B. G.
(2010).
Contributions of surface topography and cytotoxicity to the macrophage response to zinc oxide nanorods. Biomaterials.
31(11), 2999-3007.
-
Lee, J., Chu, B. H., Chen, K., Ren, F., & Lele, T. P.
(2009).
Randomly oriented, upright SiO2 coated nanorods for reduced adhesion of mammalian cells. Biomaterials.
30(27), 4488-4493.
-
Russell, R. J., Xia, S., Dickinson, R. B., & Lele, T. P.
(2009).
Sarcomere mechanics in capillary endothelial cells. Biophysical Journal.
97(6), 1578-1585.
-
Chu, B. H., Lee, J., Chang, C. Y., Jiang, P., Tseng, Y., Pearton, S. J., ... Ren, F.
(2009).
The study of low temperature hydrothermal growth of ZnO nanorods on stents and its applications of cell adhesion and viability. Applied Surface Science.
255(20), 8309-8312.
-
Wang, Y., Chu, B. H., Chen, K. H., Chang, C. Y., Lele, T. P., Papadi, G., ... Ren, F.
(2009).
Fast detection of a protozoan pathogen, Perkinsus marinus, using AlGaN/GaN high electron mobility transistors. 94(24), 243901.
-
Chen, K., Kang, B. S., Wang, H. T., Lele, T. P., Ren, F., Wang, Y. L., ... Linthicum, K. J.
(2009).
c-erbB-2 Sensing Using AlGaN/GaN High Electron Mobility Transistors For Breast Cancer Detection. ECS Transactions.
19(3), 57-63.
-
Pearton, S. J., Ren, F., Kang, B., Wang, Y. L., Chu, B., Chen, K., ... Dabiran, A.
(2009).
Biosensors Using Functionalized ZnO and GaN Surfaces. ECS Meeting Abstracts.
MA2009-01(12), 576-576.
-
Chu, B. H., Chang, C. Y., Leu, L. C., Norton, D., Lee, J., Lele, T. P., ... Ren, F.
(2009).
Hydrothermally Grown ZnO Nanorods as Cell Adhesion Control Coating for Implant Devices. ECS Transactions.
19(3), 147-157.
-
Chu, B. H., Chang, C. Y., Lee, J., Lele, T. P., Jiang, P., Tseng, Y., ... Ren, F.
(2009).
Low Temperature Hydrothermal Growth of ZnO Nanorods and its Applications. ECS Meeting Abstracts.
MA2009-01(21), 888-888.
-
Wang, Y., Chu, B. H., Chen, K., Chang, C. Y., Lele, T. P., Tseng, Y., ... Ren, F.
(2009).
Real-time Detection of Botulinum Toxin with AlGaN/GaN High Electron Mobility Transistors. ECS Transactions.
19(3), 123-128.
-
Wang, Y., Chu, B. H., Chen, K., Chang, C. Y., Lele, T. P., Tseng, Y., ... Ren, F.
(2009).
Real-time detection of botulinum toxin with AlGaN/GaN high electron mobility transistor. ECS Meeting Abstracts.
MA2009-01(21), 884-884.
-
Lee, J., Chu, B. H., Gupte, A., Ren, F., & Lele, T.
(2009).
S2046 Reducing Tumor Growth On Stents Using Nanorods: Nanotechnology for the Prevention of Cell Adhesion and Migration. Gastroenterology.
136(5), a-319.
-
Chen, K., Kang, B. S., Wang, H. T., Lele, T. P., Wang, Y. L., Chang, C. Y., ... Ren, F.
(2009).
c-erbB-2 Sensing using AlGaN/GaN High Electron Mobility Transistors for Breast Cancer Detection. ECS Meeting Abstracts.
MA2009-01(21), 870-870.
-
Russell, R. J., Dickinson, R. B., & Lele, T. P.
(2009).
Sarcomere Mechanics in the Stress Fiber. Biophysical Journal.
96(3), 626A-626A.
-
Wang, Y., Chu, B. H., Chen, K. H., Chang, C., Lele, T. P., Papadi, G., ... Ren, F.
(2009).
Fast Detection of Perkinsus Marinus, a Prevalent Pathogen of Oysters and Clams from Sea Waters. MRS Advances.
1202, 1202-i09-10.
-
Wang, Y., Chu, B. H., Chen, K. H., Chang, C. Y., Lele, T. P., Tseng, Y., ... Ren, F.
(2008).
Botulinum toxin detection using AlGaN/GaN high electron mobility transistors. 93(26), 262101.
-
Chu, B. H., Leu, L. C., Chang, C. Y., Lugo, F., Norton, D., Lele, T., ... Ren, F.
(2008).
Conformable coating of SiO2 on hydrothermally grown ZnO nanorods. Applied Physics Letters.
93(23), 233111.
-
Chen, K. H., Wang, H. W., Kang, B. S., Chang, C. Y., Wang, Y. L., Lele, T. P., ... Chow, P. R.
(2008).
Low Hg(II) ion concentration electrical detection with AlGaN/GaN high electron mobility transistors. Sensors and Actuators, B: Chemical.
134(2), 386-389.
-
Lee, J., Kang, B. S., Hicks, B., Chancellor, T. F., Chu, B. H., Wang, H., ... Lele, T. P.
(2008).
The control of cell adhesion and viability by zinc oxide nanorods. Biomaterials.
29(27), 3743-3749.
-
Luo, Y., Xu, X., Lele, T., Kumar, S., & Ingber, D. E.
(2008).
A multi-modular tensegrity model of an actin stress fiber. Journal of Biomechanics.
41(11), 2379-2387.
-
Dolgova, N., Lewis, J., Lele, T., Ren, F., & Keselowsky, B. G.
(2008).
Macrophage Adhesion and Viability on Zinc Oxide Nanorods. ECS Meeting Abstracts.
MA2008-02(36), 2351-2351.
-
Lee, J., Chu, B. H., Ren, F., Keselowsky, B. G., & Lele, T.
(2008).
ZnO Nanorods for Controlling Cell Behavior. ECS Meeting Abstracts.
MA2008-02(36), 2361-2361.
-
Chen, K. H., Kang, B. S., Wang, H. T., Lele, T. P., Ren, F., Wang, Y. L., ... Linthicum, K. J.
(2008).
c-erbB-2 sensing using AlGaN/GaN high electron mobility transistors for breast cancer detection. 92(19), 192103.
-
Kang, B. S., Wang, H., Ren, F., Chancellor, T. J., Lele, T. P., Tseng, Y., ... Chow, P. P.
(2008).
AlGaN/GaN HEMT And ZnO Nanorod Based Sensors for Chemical and Bio-Applications. ECS Transactions.
13(3), 53-63.
-
Ren, F., Kang, B. S., Wang, H., Chancellor, T. J., Lele, T. P., Tseng, Y., ... Chow, P. P.
(2008).
AlGaN/GaN HEMT And ZnO Nanorod Based Sensors for Chemical and Bio-Applications. ECS Meeting Abstracts.
MA2008-01(20), 760-760.
-
Lele, T. P., Thodeti, C. K., Pendse, J., & Ingber, D. E.
(2008).
Investigating complexity of protein-protein interactions in focal adhesions. Biochemical and Biophysical Research Communications.
369(3), 929-934.
-
Chancellor, T. F., Russell, R. J., Dravid, V., & Lele, T. P.
(2008).
Toward in situ biochemistry: combining chemical kinetics approaches with biomolecular imaging in living cells. Biotechnology Progress.
24(1), 89-95.
-
Ren, F., Lele, T., & Pearton, S. J.
(2008).
New sensors offer promise of bedside diagnosis. SPIE newsroom.
-
Pearton, S. J., Lele, T., Tseng, Y., & Ren, F.
(2007).
Penetrating living cells using semiconductor nanowires. Trends in Biotechnology.
25(11), 481-482.
-
Wang, H., Kang, B. S., Chancellor, T. J., Lele, T., Tseng, Y., Ren, F., ... Linthicum, K.
(2007).
Rapid Electrical Detection of Hg(II) Ions with AlGaN/GaN High Electron Mobility Transistors. ECS Transactions.
11(5), 83-89.
-
Kang, B. S., Wang, H. T., Lele, T. P., Tseng, Y., Ren, F., Pearton, S. J., ... Linthicum, K. J.
(2007).
Prostate specific antigen detection using AlGaN/GaN high electron mobility transistors. 91(11), 112106.
-
Pearton, S., Ren, F., Kang, B. S., Wang, H., Gila, B., Norton, D., ... Lin, J.
(2007).
GaN and ZnO-Based Sensors for Gas, Nuclear Materials and Chemical Detection. ECS Transactions.
11(5), 259-270.
-
Pearton, S., Ren, F., Kang, B. S., Wang, H., Gila, B., Norton, D., ... Lin, J.
(2007).
GaN and ZnO-Based Sensors for Gas, Nuclear Materials and Chemical Detection. ECS Meeting Abstracts.
MA2007-02(26), 1343-1343.
-
Wang, H., Kang, B. S., Chancellor, T. J., Lele, T., Tseng, Y., Ren, F., ... Linthicum, K.
(2007).
Rapid Electrical Detection of Hg(II) Ions with AlGaN/GaN High Electron Mobility Transistors. ECS Meeting Abstracts.
MA2007-02(24), 1261-1261.
-
Wang, H., Kang, B. S., Chancellor, T., Lele, T. P., Tseng, Y., Ren, F., ... Linthicum, K. J.
(2007).
Fast electrical detection of Hg(II) ions with AlGaN/GaN high electron mobility transistors. 91(4), 042114.
-
Lele, T. P., & Kumar, S.
(2007).
Brushes, cables, and anchors: recent insights into multiscale assembly and mechanics of cellular structural networks. Cell Biochemistry and Biophysics.
47(3), 348-360.
-
Lele, T. P., Sero, J. E., Matthews, B. D., Kumar, S., Xia, S., Montoya-Zavala, M., ... Ingber, D. E.
(2007).
Tools to study cell mechanics and mechanotransduction. Methods in Cell Biology.
83, 443-472.
-
Wang, H. T., Kang, B. S., Chancellor, T., Lele, T. P., Tseng, Y., Ren, F., ... Chow, P. P.
(2007).
Selective detection of Hg (II) ions from Cu(II) and Pb(II) using AlGaN/GaN high electron mobility transistors. ECS Electrochemistry Letters.
10(11), J150-J153.
-
Lele, T., Wagner, S. R., Nickerson, J. A., & Ingber, D. E.
(2006).
Methods for measuring rates of protein binding to insoluble scaffolds in living cells: histone H1-chromatin interactions. Journal of Cellular Biochemistry.
99(5), 1334-1342.
-
Sharp, Z. D., Mancini, M. G., Hinojos, C. A., Dai, F., Berno, V., Szafran, A. T., ... Mancini, M. A.
(2006).
Estrogen-receptor- exchange and chromatin dynamics are ligand- and domain-dependent. Journal of Cell Science.
119(20), 4365-4365.
-
Kumar, S., Maxwell, I. Z., Heisterkamp, A., Polte, T. R., Lele, T. P., Salanga, M., Mazur, E., & Ingber, D. E.
(2006).
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophysical Journal.
90(10), 3762-3773.
-
Lele, T. P., Thodeti, C. K., & Ingber, D. E.
(2006).
Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching. Journal of Cellular Biochemistry.
97(6), 1175-1183.
-
Lele, T. P., Pendse, J., Kumar, S., Salanga, M., Karavitis, J., & Ingber, D. E.
(2006).
Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. Journal of Cellular Physiology.
207(1), 187-194.
-
Lele, T. P., & Ingber, D. E.
(2006).
A mathematical model to determine molecular kinetic rate constants under non-steady state conditions using fluorescence recovery after photobleaching (FRAP). Biophysical Chemistry.
120(1), 32-35.
-
McMillan, N., Lele, T., Snively, C., & Lauterbach, J.
(2005).
Subsurface oxygen formation on Pt(100): Experiments and modeling. Catalysis Today.
105(2), 244-253.
-
Lele, T., Oh, P., Nickerson, J. A., & Ingber, D. E.
(2004).
An improved mathematical approach for determination of molecular kinetics in living cells with FRAP. Mechanics & chemistry of biosystems : MCB.
1(3), 181-190.
-
Lele, T., Lauterbach, J., & Ramkrishna, D.
(2003).
Mathematical analysis of physicochemical processes on catalytic surfaces. 49(8), 2158-2172.
-
Lele, T., & Lauterbach, J.
(2002).
Spatio-temporal pattern formation during CO oxidation on Pt(100) at low and intermediate pressures: A comparative study. Chaos.
12(1), 164-171.
-
Lele, T. P., Pletcher, T. D., & Lauterbach, J.
(2001).
Spatiotemporal patterns during CO oxidation on Pt(100) at elevated pressures. AIChE Journal.
47(6), 1418-1424.
-
Wang, T., Abolghasemzade, S., McKee, B. P., Singh, I., Pendyala, K., Mohajeri, M., ... Lele, T. P.
Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization. Nature Communications.
15(1), 10151.
-
Dickinson, R. B., Abolghasemzade, S., & Lele, T. P.
Rethinking nuclear shaping: insights from the nuclear drop model. SOFT MATTER.
-
Scott, K. L., Halfmann, C. T., Hoefakker, A. D., Purkayastha, P., Wang, T. C., Lele, T. P., & Roux, K. J.
(2024).
Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability. Journal of Cell Biology.
223(7), e202308152.
-
chapter
-
Tocco, V. J., Neelam, S., Zhang, Q., Dickinson, R. B., & Lele, T. P.
(2018).
Direct Force Probe for Nuclear Mechanics. Methods in molecular biology (Clifton, N.J.).
LINC COMPLEX: METHODS AND PROTOCOLS.
(pp. 81-90).
Springer Nature.
-
Alam, S., Lovett, D. B., Dickinson, R. B., Roux, K. J., & Lele, T. P.
(2014).
Nuclear forces and cell mechanosensing. Progress in Molecular Biology and Translational Science.
MECHANOTRANSDUCTION.
(pp. 205-215).
Elsevier.
-
Lele, T. P.
(2010).
Enhanced Cell Growth, Function, and Differentiation by TiO2 Nanotube Surface Structuring. Nanotechnology in Tissue Engineering and Regenerative Medicine.
(pp. 157-166).
Taylor & Francis.
-
Zaveri, T., Dolgova, N., Chu, B. H., Lee, J., Lele, T., Ren, F., & Keselowsky, B. G.
(2009).
Macrophage Response to Zinc Oxide Nanorod Surfaces -Topography and Toxicity. IFMBE proceedings.
25th Southern Biomedical Engineering Conference 2009, 15 17 May 2009, Miami, Florida, USA.
(pp. 119-120).
Springer Nature.
-
Lele, T., & Ingber, D. E.
(2008).
Focal Adhesions: Self-Assembling Nanoscale Mechanochemical Machines that Control Cell Function. BIOMEDICAL NANOSTRUCTURES.
(pp. 321-335).
Wiley.
-
Goldmann, W. H., Bechinger, B., & Lele, T.
(2008).
CYTOSKELETAL PROTEINS AT THE LIPID MEMBRANE. Advances in planar lipid bilayers and liposomes.
ADVANCES IN PLANAR LIPID BILAYERS AND LIPOSOMES, VOL 6.
(pp. 227-255).
-
Goldmann, W. H., Bechinger, B., & Lele, T.
(2008).
Chapter Eight Cytoskeletal Proteins at the Lipid Membrane. Advances in Biomembranes and Lipid Self-Assembly.
Leitmannova Liu, A. (Eds.),
Advances in Planar Lipid Bilayers and Liposomes.
(pp. 227-264).
Elsevier.
-
Lele, T. P., Sero, J. E., Matthews, B. D., Kumar, S., Xia, S., Montoya-Zavala, M., ... Ingber, D. E.
(2007).
Tools to study cell mechanics and mechanotransduction. Methods in Cell Biology.
CELL MECHANICS.
(pp. 443-472).
Elsevier.
-
Tocco, V. J., Neelam, S., Zhang, Q., Dickinson, R. B., & Lele, T. P.
(2018).
Direct Force Probe for Nuclear Mechanics. Methods in molecular biology (Clifton, N.J.).
LINC COMPLEX: METHODS AND PROTOCOLS.
(pp. 81-90).
Springer Nature.
-
conference paper
-
Lele, T. P.
(2023).
Insights developed into nuclear mechanics by live cell imaging. 15.
-
Narayanan, V., Purkayastha, P., Yu, B., Dickinson, R., Conway, D. E., & Lele, T. P.
(2023).
Loss of mechanical homeostasis drives epithelial acinar eversion. Molecular Biology of the Cell.
1073-1073.
-
Scott, K. L., Purkayastha, P., Lele, T. P., & Roux, K. J.
(2023).
Nucleocytoplasmic transport is regulated by forces on the nucleus. Molecular Biology of the Cell.
186-186.
-
Scott, K. L., Purkayastha, P., Lele, T. P., & Roux, K. J.
(2023).
Nucleocytoplasmic transport is regulated by forces on the nucleus. Molecular Biology of the Cell.
219-219.
-
Rayer, M., Mui, K., Nickerson, A., Lele, T. P., & Gundersen, G. G.
(2023).
The LINC complex controls global breast acini architecture through connections to the actin cytoskeleton. Molecular Biology of the Cell.
369-370.
-
Katiyar, A., Zhang, J., Antani, J., Yu, Y., Scott, K., Lele, P. P., ... Lele, T. P.
(2023).
The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C. Molecular Biology of the Cell.
615-615.
-
Cheburkanov, V., Purkayastha, P., Pendyala, K., Lele, T., & Yakovlev, V. V.
(2022).
Brillouin spectroscopy imaging of cell phototoxic damage. Proceedings of SPIE.
119400k-119400k-6.
-
Cheburkanov, V., Pendyala, K., Parlani, M., Lele, T., Friedl, P., & Yakovlev, V.
(2022).
Imaging mechanical properties of cancer cells during metastasis with Brillouin microspectroscopy. Proceedings of SPIE.
119440c-119440c-9.
-
Tamashunas, A., Tocco, V., Matthews, J., Zhang, Q., Pathak, S., Licht, J., ... Lele, T.
(2019).
Gene screen reveals chromatin proteins influence abnormal nuclear morphology associated with breast cancer cell models. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Halfmann, C. T., Sears, R. M., Aman, L., Zhang, Q., Katiyar, A., O'Bryan, C. S., ... Roux, K. J.
(2018).
Barrier to autointegration factor (BAF) regulates the cellular response to nuclear rupture. Molecular Biology of the Cell.
-
Tamashunas, A. C., Tocco, V. J., Matthews, J., Licht, J. D., Stephens, A. D., Luesch, H., & Lele, T. P.
(2018).
Gene screen reveals chromatin proteins influence abnormal nuclear morphology associated with breast cancer cell models. Molecular Biology of the Cell.
-
Zhang, Q., Tamashunas, A. C., Torbati, M., Agrawal, A., Dickinson, R. B., Lammerding, J., & Lele, T. P.
(2018).
Local nuclear deformation in response to transient tensile stress can cause membrane rupture. Molecular Biology of the Cell.
-
Kent, I. A., Rane, P., Ladd, A. J., Lele, T. P., & Dickinson, R. B.
(2014).
Dynein-generated forces bend and reorient microtubules by acting upon stationary pinning points. Molecular Biology of the Cell.
-
Li, Y., Lovett, D., Zhang, Q., Kuchibhotla, R., Neelam, S., Zhu, R., ... Lele, T. P.
(2014).
The Mechanics of Nuclear Shaping. Molecular Biology of the Cell.
-
Alam, S., Lovett, D., Roux, K. J., Dickinson, R. B., & Lele, T. P.
(2014).
The nucleus is an intracellular propagator of actomyosin forces in NIH 3T3 fibroblasts. Molecular Biology of the Cell.
-
Wu, J., Chancellor, T., Shekhar, N., Mendonca, A., Dickinson, R. B., & Lele, T. P.
(2013).
Actomyosin tug-of-war advances the nucleus in a migrating tissue cell. Molecular Biology of the Cell.
-
Wu, J., Shekhar, N., Misra, G., Russell, R. J., Ladd, A. J., Dickinson, R. B., & Lele, T. P.
(2012).
Effects of Molecular Motors on Microtubule Mechanics. Molecular Biology of the Cell.
-
Wu, J., Dickinson, R. B., Lee, K. C., & Lele, T. P.
(2012).
How Dynein and Microtubules Rotate the Nucleus. Molecular Biology of the Cell.
-
Chu, B. H., Kang, B. S., Wang, H. T., Chang, C. Y., Lele, T., Tseng, Y., ... Ren, F.
(2009).
AlGaN/GaN HEMT And ZnO nanorod-based sensors for chemical and bio-applications. Proceedings of SPIE.
72162a-72162a-10.
-
Desai, R., Lele, T., & Viens, F.
(2003).
A Monte-Carlo method for portfolio optimization under partially observed stochastic volatility. 257-263.
-
Lele, T. P.
(2023).
Insights developed into nuclear mechanics by live cell imaging. 15.
-
institutional repository document
-
Scott, K. L., Halfmann, C. T., Hoefakker, A. D., Purkayastha, P., Wang, T. C., Lele, T. P., & Roux, K. J.
(2023).
Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability
-
Dickinson, R. B., & Lele, T. P.
(2022).
A predictive unifying explanation for nuclear shapes based on a simple geometric principle
-
Narayanan, V., Purkayastha, P., Yu, B. o., Pendyala, K., Chukkapalli, S., Cabe, J. I., ... Lele, T. P.
(2022).
Rho activation drives luminal collapse and eversion in epithelial acini
-
Katiyar, A., Zhang, J., Antani, J. D., Yu, Y., Scott, K. L., Lele, P. P., ... Lele, T. P.
(2022).
The nucleus bypasses obstacles by deforming like a drop with surface tension mediated by lamin A/C
-
Antani, J. D., Sumali, A. X., Lele, T. P., & Lele, P. P.
(2020).
Anisotropic random walks reveal chemotaxis signaling output in run-reversing bacteria
-
Purkayastha, P., Pendyala, K., Saxena, A. S., Hakimjavadi, H., Chamala, S., Dixit, P., Baer, C. F., & Lele, T. P.
(2020).
Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblasts propagated on a novel soft substrate
-
Scott, K. L., Halfmann, C. T., Hoefakker, A. D., Purkayastha, P., Wang, T. C., Lele, T. P., & Roux, K. J.
(2023).
Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability
Research
principal investigator on
- RoL: FELS: EAGER Rules for cellular adaptation to the mechanical properties of their environment awarded by Directorate for Biological Sciences - (Arlington, Virginia, United States) 2020 - 2021
- Nuclear Dysfunction in Cancer: The Role of Mechanical Stresses Transmitted by the LINC Complex awarded by National Cancer Institute - (Rockville, Maryland, United States)
Teaching
teaching activities
- BIOT684 Directed Prof Internship Instructor
- BIOT685 Directed Studies Instructor
- BMEN491 Hnr-research Instructor
- BMEN491 Hnr-research Instructor
- BMEN685 Directed Studies Instructor
- BMEN689 Sptp: Cancer Mechanobiology Instructor
- BMEN689 Sptp:cancer Mechanobiology Instructor
- BMEN691 Research Instructor
- CHEN364 Kinetics & Reactor Design Instructor
- CHEN691 Research Instructor
Works By Students
chaired theses and dissertations
-
Katiyar, Aditya (2022-05). Studying Nuclear Deformation During Migration of Cells through Confining Environments.
-
Purkayastha, Purboja (2022-08). Cell and Tissue Adaptation to Mechanical Alterations.
Background
education and training
- Ph.D. in Chemical Engineering, Purdue University - (West Lafayette, Indiana, United States) 2002
awards and honors
Contact
first name
- Tanmay
has last name
- Lele
mailing address
-
Department of Biomedical Engineering
Emerging Technologies Building, Room #5062, 101 Bizzell Street,
Texas A&M University
College Station, TX 77840., TX 77840
USA
Other
In the News
- tanmay.lele@tamu.edu