Cells shape and position the nucleus by transmitting forces from the cytoskeleton onto the nuclear surface. In response to these forces, the nucleus can deform and/or it can move. Nuclear movement will occur when there is a net differential in mechanical force across the nucleus, while nuclear deformation will occur when mechanical forces overcome the mechanical resistance of the various structures that comprise the nucleus. In this talk, I will describe our efforts to 1) identify the sources of mechanical forces and quantify the magnitude of mechanical force generation on the nucleus, 2) understand the mechanical response of the nucleus to these forces, and 3) uncover the relevance of nuclear force transfer in cell and tissue function.Support or Funding InformationNIHNSF
