Prostate specific antigen detection using AlGaN/GaN high electron mobility transistors Academic Article uri icon

abstract

  • Antibody-functionalized Au-gated AlGaNGaN high electron mobility transistors (HEMTs) were used to detect prostate specific antigen (PSA). The PSA antibody was anchored to the gate area through the formation of carboxylate succinimdyl ester bonds with immobilized thioglycolic acid. The AlGaNGaN HEMT drain-source current showed a rapid response of less than 5s when target PSA in a buffer at clinical concentrations was added to the antibody-immobilized surface. The authors could detect a wide range of concentrations from 10pgmlto1gml. The lowest detectable concentration was two orders of magnitude lower than the cutoff value of PSA measurements for clinical detection of prostate cancer. These results clearly demonstrate the promise of portable electronic biological sensors based on AlGaNGaN HEMTs for PSA screening.

published proceedings

  • APPLIED PHYSICS LETTERS

altmetric score

  • 3

author list (cited authors)

  • Kang, B. S., Wang, H. T., Lele, T. P., Tseng, Y., Ren, F., Pearton, S. J., ... Linthicum, K. J.

citation count

  • 95

publication date

  • September 2007