Cytoplasmic dynein: tension generation on microtubules and the nucleus. Academic Article

abstract

• Cytoplasmic dynein is a microtubule dependent motor protein that is central to vesicle transport, cell division and organelle positioning. Recent studies suggest that dynein can generate significant pulling forces on intracellular structures as it motors along microtubules. In this review, we discuss how dynein-generated pulling forces position the nucleus and the centrosome.

authors

• Lele, Tanmay

published proceedings

• Cell Mol Bioeng

author list (cited authors)

• Shekhar, N., Wu, J., Dickinson, R. B., & Lele, T. P.

citation count

• 13

complete list of authors

• Shekhar, Nandini||Wu, Jun||Dickinson, Richard B||Lele, Tanmay P

publication date

• March 2013

publisher

• Springer Nature  Publisher

published in

• Cellular and Molecular Bioengineering  Journal

keywords

• Centrosome Centering
• Cytoplasmic Dynein
• Force Generation
• Nuclear Positioning

PubMed Central ID

• 23646068

Digital Object Identifier (DOI)

• 10.1007/s12195-012-0257-4

start page

• 74

end page

• 81

volume

• 6

issue

• 1

URL

• http://dx.doi.org/10.1007/s12195-012-0257-4