An unresolved LINC in the nuclear envelope. Academic Article

abstract

• The nuclear envelope segregates the nucleoplasm from the cytoplasm and is a key feature of eukaryotic cells. Nuclear envelope architecture is comprised of two concentric membrane shells which fuse at multiple sites and yet maintain a uniform separation of 30-50 nm over the rest of the membrane. Studies have revealed the roles for numerous nuclear proteins in forming and maintaining the architecture of the nuclear envelope. However, there is a lack of consensus on the fundamental forces and physical mechanisms that establish the geometry. The objective of this review is to discuss recent findings in the context of membrane mechanics in an effort to define open questions and possible answers.

authors

• Lele, Tanmay

published proceedings

• Cell Mol Bioeng

author list (cited authors)

• Torbati, M., Lele, T. P., & Agrawal, A.

citation count

• 8

complete list of authors

• Torbati, Mehdi||Lele, Tanmay P||Agrawal, Ashutosh

publication date

• June 2016

publisher

• Springer Nature  Publisher

published in

• Cellular and Molecular Bioengineering  Journal

keywords

• Geometry
• Linc Complex
• Membrane
• Nuclear Envelope

PubMed Central ID

• 27330571

Digital Object Identifier (DOI)

• 10.1007/s12195-016-0431-1

start page

• 252

end page

• 257

volume

• 9

issue

• 2

URL

• http://dx.doi.org/10.1007/s12195-016-0431-1