HR job title
- Professor
- Contact Info
- 1 713 677 7551
Hook, Magnus Professor
Positions
- Regents & Distinguished Professor and Director, Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology
The primary interest of our laboratory is to try to understand the structural function of the extracellular matrix. Of particular interest is the study of the molecular mechanisms of microbial adhesion to host tissue. This process, which is believed to represent a critical initial step in the development of infections, involves specific cell-surface proteins that recognize and bind with a high affinity to components in the host tissue. Our goal is to decipher these events at a molecular level and, based on structural analysis of the interacting components, design new strategies to prevent and treat infections.
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Overview
Publications
selected publications
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academic article
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Pagba, C. V., Gupta, A. K., Naji, A. K., van der Hoeven, D., Churion, K., Liang, X., ... Gorfe, A. A.
(2022).
KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement. 2(6), 617-626.
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Negrn, O., Hur, W. S., Prasad, J., Paul, D. S., Rowe, S. E., Degen, J. L., ... Flick, M. J.
(2022).
Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection. PLOS Pathogens.
18(1), e1010227-e1010227.
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Picker, J., Lan, Z., Arora, S., Green, M., Hahn, M., Cosgriff-Hernandez, E., & Hook, M.
(2022).
Prokaryotic Collagen-Like Proteins as Novel Biomaterials. Frontiers in Bioengineering and Biotechnology.
10, 840939.
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Borza, C. M., Bolas, G., Zhang, X., Browning Monroe, M. B., Zhang, M., Meiler, J., ... Pozzi, A.
(2022).
The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin 1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation. Frontiers in Cell and Developmental Biology.
10, 836797.
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Thomas, S., Arora, S., Liu, W., Churion, K., Wu, Y., & Hk, M.
(2021).
vhp Is a Fibrinogen-Binding Protein Related to vWbp in Staphylococcus aureus. mBio.
12(4), e0116721-e01121.
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Taylor, J. C., Gao, X., Xu, J., Holder, M., Petrosino, J., Kumar, R., ... Xu, Y. i.
(2021).
A type VII secretion system of Streptococcus gallolyticus subsp. gallolyticus contributes to gut colonization and the development of colon tumors. PLOS Pathogens.
17(1), e1009182-e1009182.
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DebRoy, S., Aliaga-Tobar, V., Galvez, G., Arora, S., Liang, X., Horstmann, N., ... Shelburne, S. A.
(2021).
Genome-wide analysis of in vivo CcpA binding with and without its key co-factor HPr in the major human pathogen group A Streptococcus. Molecular Microbiology.
115(6), 1207-1228.
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Prasad, J. M., Negrn, O., Du, X., Mullins, E. S., Palumbo, J. S., Gilbertie, J. M., ... Flick, M. J.
(2021).
Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation. Proceedings of the National Academy of Sciences of the United States of America.
118(1), e2009837118.
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Arora, S., Gordon, J., & Hook, M.
(2021).
Collagen Binding Proteins of Gram-Positive Pathogens. Frontiers in Microbiology.
12, 628798.
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Hook, M., & Foster, T. J.
(2021).
Editorial: Cell Surface Proteins of Gram-Positive Pathogenic Bacteria. Frontiers in Microbiology.
12, 681880.
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Bordin, A. I., Cohen, N. D., Gigure, S., Bray, J. M., Berghaus, L. J., Scott, B., Johnson, R., & Hook, M.
(2021).
Host-directed therapy in foals can enhance functional innate immunity and reduce severity of Rhodococcus equi pneumonia. Scientific Reports.
11(1), 2483.
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Evans, S. E., Tseng, C., Scott, B. L., Hk, A. M., & Dickey, B. F.
(2020).
Inducible Epithelial Resistance against Coronavirus Pneumonia in Mice. American Journal of Respiratory Cell and Molecular Biology.
63(4), 540-541.
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Arora, S., Li, X., Hillhouse, A., Konganti, K., Little, S. V., Lawhon, S. D., ... Hook, M.
(2020).
Staphylococcus epidermidis MSCRAMM SesJ Is Encoded in Composite Islands. mBio.
11(1), e02911-e02919.
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Post, A., Isgandarova, S., Martinez-Moczygemba, M., Hahn, M., Russell, B., Hook, M., & Cosgriff-Hernandez, E.
(2019).
Elucidation of Endothelial Cell Hemostatic Regulation with Integrin-Targeting Hydrogels. Annals of Biomedical Engineering.
47(3), 866-877.
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Casillas-Ituarte, N. N., DiBartola, A. C., Broughton, M. J., Prez-Guzmn, L., Wheeler, R. M., Ibaraki, M., ... Sharma-Kuinkel, B. K.
(2019).
Fibrinogen binding is affected by amino acid substitutions in C-terminal repeat region of fibronectin binding protein A. Scientific Reports.
9(1), 11619.
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Pickering, A. C., Vitry, P., Prystopiuk, V., Garcia, B., Hk, M., Schoenebeck, J., ... Fitzgerald, J. R.
(2019).
Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion. PLOS Pathogens.
15(6), e1007816-e1007816.
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Diaz Quiroz, J. F., Rodriguez, P. D., Erndt-Marino, J. D., Guiza, V., Balouch, B., Graf, T., ... Hahn, M. S.
(2018).
Collagen-Mimetic Proteins with Tunable Integrin Binding Sites for Vascular Graft Coatings. ACS Biomaterial Science and Engineering.
4(8), 2934-2942.
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Becerra-Bayona, S. M., Guiza-Arguello, V. R., Russell, B., Hk, M., & Hahn, M. S.
(2018).
Influence of collagen-based integrin 1 and 2 mediated signaling on human mesenchymal stem cell osteogenesis in three dimensional contexts. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.
106(10), 2594-2604.
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Casillas-Ituarte, N. N., Cruz, C., Lins, R. D., DiBartola, A. C., Howard, J., Liang, X., ... Lower, S. K.
(2017).
Amino acid polymorphisms in the fibronectin-binding repeats of fibronectin-binding protein A affect bond strength and fibronectin conformation. 292(21), 8797-8810.
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Munoz-Pinto, D. J., Erndt-Marino, J. D., Becerra-Bayona, S. M., Guiza-Arguello, V. R., Samavedi, S., Malmut, S., ... Hahn, M. S.
(2017).
Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.
105(6), 1712-1724.
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Liang, X., Garcia, B. L., Visai, L., Prabhakaran, S., Meenan, N., Potts, J. R., Humphries, M. J., & Hk, M.
(2016).
Allosteric Regulation of Fibronectin/51 Interaction by Fibronectin-Binding MSCRAMMs. PLoS ONE.
11(7), e0159118-e0159118.
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Ko, Y., Kang, M., Ganesh, V. K., Ravirajan, D., Li, B., & Hk, M.
(2016).
Coagulase and Efb of Staphylococcus aureus Have a Common Fibrinogen Binding Motif. mBio.
7(1), e01885-e01815.
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Arora, S., Uhlemann, A., Lowy, F. D., & Hook, M.
(2016).
A Novel MSCRAMM Subfamily in Coagulase Negative Staphylococcal Species. Frontiers in Microbiology.
7(APR), 540.
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Kang, M., Thomas, S., Ganesh, V. K., Ko, Y., & Hook, M.
(2016).
Complement evasion by Staphylococcus aureus Bbp and SdrE that act on the C3 convertase. IMMUNOBIOLOGY.
221(10), 1145-1145.
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Ganesh, V. K., Liang, X., Geoghegan, J. A., Cohen, A., Venugopalan, N., Foster, T. J., & Hook, M.
(2016).
Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody. EBioMedicine.
13, 328-338.
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Garcia, B. L., Zhi, H., Wager, B., Hk, M., & Skare, J. T.
(2016).
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. PLOS Pathogens.
12(1), e1005404-e1005404.
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Somarajan, S. R., La Rosa, S. L., Singh, K. V., Roh, J. H., Hk, M., & Murray, B. E.
(2015).
The fibronectin-binding protein Fnm contributes to adherence to extracellular matrix components and virulence of Enterococcus faecium. Infection and Immunity.
83(12), 4653-4661.
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Munoz-Pinto, D. J., Guiza-Arguello, V. R., Becerra-Bayona, S. M., Erndt-Marino, J., Samavedi, S., Malmut, S., ... Hahn, M. S.
(2015).
Collagen-mimetic hydrogels promote human endothelial cell adhesion, migration and phenotypic maturation. Journal of Materials Chemistry B.
3(40), 7912-7919.
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Prasad, J. M., Gorkun, O. V., Raghu, H., Thornton, S., Mullins, E. S., Palumbo, J. S., ... Flick, M. J.
(2015).
Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood.
126(17), 2047-2058.
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Zhi, H., Weening, E. H., Barbu, E. M., Hyde, J. A., Hk, M., & Skare, J. T.
(2015).
The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis. Molecular Microbiology.
96(1), 68-83.
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Galloway-Pea, J. R., Liang, X., Singh, K. V., Yadav, P., Chang, C., La Rosa, S. L., ... Murray, B. E.
(2015).
The identification and functional characterization of WxL proteins from Enterococcus faecium reveal surface proteins involved in extracellular matrix interactions. Journal of Bacteriology.
197(5), 882-892.
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Cereceres, S., Touchet, T., Browning, M. B., Smith, C., Rivera, J., Hk, M., ... Cosgriff-Hernandez, E.
(2015).
Chronic Wound Dressings Based on Collagen-Mimetic Proteins. Advances in Wound Care.
4(8), 444-456.
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Browning, M. B., Guiza, V., Russell, B., Rivera, J., Cereceres, S., Hk, M., Hahn, M. S., & Cosgriff-Hernandez, E. M.
(2014).
Endothelial cell response to chemical, biological, and physical cues in bioactive hydrogels. Tissue Engineering Part A.
20(23-24), 3130-3141.
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Bronk, J. K., Russell, B. H., Rivera, J. J., Pasqualini, R., Arap, W., Hk, M., & Barbu, E. M.
(2014).
A multifunctional streptococcal collagen-mimetic protein coating prevents bacterial adhesion and promotes osteoid formation on titanium. Acta Biomaterialia.
10(7), 3354-3362.
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Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Hk, M.
(2014).
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus. Nature Reviews Microbiology.
12(1), 49-62.
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Barbu, E. M., Mackenzie, C., Foster, T. J., & Hk, M.
(2014).
SdrC induces staphylococcal biofilm formation through a homophilic interaction. Molecular Microbiology.
94(1), 172-185.
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Kang, M., Ko, Y., Liang, X., Ross, C. L., Liu, Q., Murray, B. E., & Hk, M.
(2013).
Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway. Journal of Biological Chemistry.
288(28), 20520-20531.
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Browning, M. B., Russell, B., Rivera, J., Hk, M., & Cosgriff-Hernandez, E. M.
(2013).
Bioactive hydrogels with enhanced initial and sustained cell interactions. Biomacromolecules.
14(7), 2225-2233.
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Cohen, A., Roh, J. H., Nallapareddy, S. R., Hk, M., & Murray, B. E.
(2013).
Expression of the collagen adhesin ace by Enterococcus faecalis strain OG1RF is not repressed by Ers but requires the Ers box. FEMS Microbiology Letters.
344(1), 18-24.
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Bix, G., Fu, J., Gonzalez, E. M., Macro, L., Barker, A., Campbell, S., ... Iozzo, R. V.
(2013).
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through 21 integrin. The Journal of Cell Biology.
201(4), 641-641.
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Flick, M. J., Du, X., Prasad, J. M., Raghu, H., Palumbo, J. S., Smeds, E., Hk, M., & Degen, J. L.
(2013).
Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. Blood.
121(10), 1783-1794.
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Ko, Y., Kuipers, A., Freitag, C. M., Jongerius, I., Medina, E., van Rooijen, W. J., ... Rooijakkers, S.
(2013).
Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface. 9(12), e1003816-e1003816.
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Shinomura, T., Ito, K., Hk, M., & Kimura, J. H.
(2012).
A newly identified enhancer element responsible for type II collagen gene expression. Journal of Biochemistry.
152(6), 565-575.
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Ross, C. L., Liang, X., Liu, Q., Murray, B. E., Hk, M., & Ganesh, V. K.
(2012).
Targeted protein engineering provides insights into binding mechanism and affinities of bacterial collagen adhesins. 287(41), 34856-34865.
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Allon, A. A., Ng, K. W., Hammoud, S., Russell, B. H., Jones, C. M., Rivera, J. J., ... Maher, S. A.
(2012).
Augmenting the articular cartilage-implant interface: Functionalizing with a collagen adhesion protein. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.
100(8), 2168-2175.
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Ya-Ping, K. o., Mingsong, K., Liang, X., Ross, C. L., Liu, Q., Murray, B. E., & Hk, M.
(2012).
Collagen-binding MSCRAMMS of Gram-positive bacteria inhibit complement activation via the classical pathway. IMMUNOBIOLOGY.
217(11), 1151-1151.
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Browning, M. B., Dempsey, D., Guiza, V., Becerra, S., Rivera, J., Russell, B., ... Cosgriff-Hernandez, E.
(2012).
Corrigendum to Multilayer vascular grafts based on collagen-mimetic proteins [Acta Biomaterialia 8 (2012) 10101021]. Acta Biomaterialia.
8(12), 4455-4455.
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Browning, M. B., Dempsey, D., Guiza, V., Becerra, S., Rivera, J., Russell, B., ... Cosgriff-Hernandez, E.
(2012).
Multilayer vascular grafts based on collagen-mimetic proteins. Acta Biomaterialia.
8(3), 1010-1021.
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Hyde, J. A., Weening, E. H., Chang, M., Trzeciakowski, J. P., Hk, M., Cirillo, J. D., & Skare, J. T.
(2011).
Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity. Molecular Microbiology.
82(1), 99-113.
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Vazquez, V., Liang, X., Horndahl, J. K., Ganesh, V. K., Smeds, E., Foster, T. J., & Hook, M.
(2011).
Fibrinogen is a ligand for the Staphylococcus aureus microbial surface components recognizing adhesive matrix molecules (MSCRAMM) bone sialoprotein-binding protein (Bbp). 286(34), 29797-29805.
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Bannoehr, J., Ben Zakour, N. L., Reglinski, M., Inglis, N. F., Prabhakaran, S., Fossum, E., ... Fitzgerald, J. R.
(2011).
Genomic and surface proteomic analysis of the canine pathogen Staphylococcus pseudintermedius reveals proteins that mediate adherence to the extracellular matrix. 79(8), 3074-3086.
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Ganesh, V. K., Barbu, E. M., Deivanayagam, C., Le, B., Anderson, A. S., Matsuka, Y. V., ... Hk, M.
(2011).
Structural and biochemical characterization of Staphylococcus aureus clumping factor B/ligand interactions. 286(29), 25963-25972.
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Xue, Q., Gu, C., Rivera, J., Hk, M., Chen, X., Pozzi, A., & Xu, Y. i.
(2011).
Entry of Bacillus anthracis spores into epithelial cells is mediated by the spore surface protein BclA, integrin 21 and complement component C1q. Cellular Microbiology.
13(4), 620-634.
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Ko, Y., Liang, X., Smith, C. W., Degen, J. L., & Hk, M.
(2011).
Binding of Efb from Staphylococcus aureus to fibrinogen blocks neutrophil adherence. 286(11), 9865-9874.
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Wu, J., Weening, E. H., Faske, J. B., Hk, M., & Skare, J. T.
(2011).
Invasion of eukaryotic cells by Borrelia burgdorferi requires (1) integrins and Src kinase activity. Infection and Immunity.
79(3), 1338-1348.
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Marjenberg, Z. R., Ellis, I. R., Hagan, R. M., Prabhakaran, S., Hk, M., Talay, S. R., ... Schwarz-Linek, U.
(2011).
Cooperative binding and activation of fibronectin by a bacterial surface protein. Journal of Biological Chemistry.
286(3), 1884-1894.
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Staquicini, F. I., Ozawa, M. G., Moya, C. A., Driessen, W., Barbu, E. M., Nishimori, H., ... Arap, W.
(2011).
Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. 121(1), 161-173.
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Seo, N., Russell, B. H., Rivera, J. J., Liang, X., Xu, X., Afshar-Kharghan, V., & Hk, M.
(2010).
An engineered alpha1 integrin-binding collagenous sequence. 285(40), 31046-31054.
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Geoghegan, J. A., Ganesh, V. K., Smeds, E., Liang, X., Hk, M., & Foster, T. J.
(2010).
Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen. 285(9), 6208-6216.
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Staquicini, F. I., Ozawa, M. G., Moya, C. A., Driessen, W., Barbu, E. M., Soghomonyan, S., ... Arap, W.
(2010).
Abstract 582: Targeting the blood-brain barrier with a non-canonical iron-mimicry mechanism: A translational approach for the detection and treatment of human brain tumors. Cancer Research.
70(8_Supplement), 582-582.
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Cosgriff-Hernandez, E., Hahn, M. S., Russell, B., Wilems, T., Munoz-Pinto, D., Browning, M. B., Rivera, J., & Hk, M.
(2010).
Bioactive hydrogels based on Designer Collagens. Acta Biomaterialia.
6(10), 3969-3977.
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Nuka, S., Zhou, W., Henry, S. P., Gendron, C. M., Schultz, J. B., Shinomura, T., ... Hk, M.
(2010).
Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis and Cartilage.
18(1), 88-96.
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Evans, S. E., Scott, B. L., Clement, C. G., Larson, D. T., Kontoyiannis, D., Lewis, R. E., ... Dickey, B. F.
(2010).
Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. American Journal of Respiratory Cell and Molecular Biology.
42(1), 40-50.
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Barbu, E. M., Ganesh, V. K., Gurusiddappa, S., Mackenzie, R. C., Foster, T. J., Sudhof, T. C., & Hk, M.
(2010).
beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC. PLOS Pathogens.
6(1), e1000726-e1000726.
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Luo, J., Zhou, W., Zhou, X., Li, D., Weng, J., Yi, Z., ... Liu, M.
(2009).
Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development (Cambridge).
136(16), 2747-2756.
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Sillanp, J., Nallapareddy, S. R., Houston, J., Ganesh, V. K., Bourgogne, A., Singh, K. V., Murray, B. E., & Hk, M.
(2009).
A family of fibrinogen-binding MSCRAMMs from Enterococcus faecalis. Microbiology.
155(Pt 7), 2390-2400.
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Prabhakaran, S., Liang, X., Skare, J. T., Potts, J. R., & Hk, M.
(2009).
A novel fibronectin binding motif in MSCRAMMs targets F3 modules. PLoS ONE.
4(4), e5412-e5412.
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Weening, E. H., Parveen, N., Trzeciakowski, J. P., Leong, J. M., Hk, M., & Skare, J. T.
(2008).
Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection. Infection and Immunity.
76(12), 5694-5705.
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Shinomura, T., Nakamura, S., Ito, K., Shirasawa, S., Hk, M., & Kimura, J. H.
(2008).
Adsorption of follicular dendritic cell-secreted protein (FDC-SP) onto mineral deposits. Application of a new stable gene expression system. 283(48), 33658-33664.
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Ganesh, V. K., Rivera, J. J., Smeds, E., Ko, Y., Bowden, M. G., Wann, E. R., ... Hk, M.
(2008).
A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics. PLOS Pathogens.
4(11), e1000226-e1000226.
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Sillanp, J., Nallapareddy, S. R., Prakash, V. P., Qin, X., Hk, M., Weinstock, G. M., & Murray, B. E.
(2008).
Identification and phenotypic characterization of a second collagen adhesin, Scm, and genome-based identification and analysis of 13 other predicted MSCRAMMs, including four distinct pilus loci, in Enterococcus faecium. Microbiology.
154(Pt 10), 3199-3211.
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Bingham, R. J., Rudio-Piera, E., Meenan, N., Schwarz-Linek, U., Turkenburg, J. P., Hk, M., Garman, E. F., & Potts, J. R.
(2008).
Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains. Proceedings of the National Academy of Sciences of the United States of America.
105(34), 12254-12258.
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Seo, N., Zeng, C., Hyser, J. M., Utama, B., Crawford, S. E., Kim, K. J., Hk, M., & Estes, M. K.
(2008).
Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proceedings of the National Academy of Sciences of the United States of America.
105(26), 8811-8818.
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Bowden, M. G., Heuck, A. P., Ponnuraj, K., Kolosova, E., Choe, D., Gurusiddappa, S., ... Hk, M.
(2008).
Evidence for the "dock, lock, and latch" ligand binding mechanism of the staphylococcal microbial surface component recognizing adhesive matrix molecules (MSCRAMM) SdrG. Journal of Biological Chemistry.
283(1), 638-647.
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Ferdous, Z., Lazaro, L. D., Iozzo, R. V., Hk, M., & Grande-Allen, K. J.
(2008).
Influence of cyclic strain and decorin deficiency on 3D cellularized collagen matrices. Biomaterials.
29(18), 2740-2748.
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Ferdous, Z., Wei, V. M., Iozzo, R., Hk, M., & Grande-Allen, K. J.
(2007).
Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices. 282(49), 35887-35898.
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Meenan, N., Visai, L., Valtulina, V., Schwarz-Linek, U., Norris, N. C., Gurusiddappa, S., ... Potts, J. R.
(2007).
The tandem beta-zipper model defines high affinity fibronectin-binding repeats within Staphylococcus aureus FnBPA. 282(35), 25893-25902.
-
Liu, Q., Ponnuraj, K., Xu, Y. i., Ganesh, V. K., Sillanp, J., Murray, B. E., Narayana, S., & Hk, M.
(2007).
The Enterococcus faecalis MSCRAMM ACE Binds Its Ligand by the Collagen Hug Model. Journal of Biological Chemistry.
282(27), 19629-19637.
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Nallapareddy, S. R., Sillanp, J., Ganesh, V. K., Hk, M., & Murray, B. E.
(2007).
Inhibition of Enterococcus faecium adherence to collagen by antibodies against high-affinity binding subdomains of Acm. Infection and Immunity.
75(6), 3192-3196.
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Caswell, C. C., Lukomska, E., Seo, N., Hk, M., & Lukomski, S.
(2007).
Scl1-dependent internalization of group A Streptococcus via direct interactions with the alpha2beta(1) integrin enhances pathogen survival and re-emergence. Molecular Microbiology.
64(5), 1319-1331.
-
Labandeira-Rey, M., Couzon, F., Boisset, S., Brown, E. L., Bes, M., Benito, Y., ... Bowden, M. G.
(2007).
Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science.
315(5815), 1130-1133.
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Rivera, J., Vannakambadi, G., Hk, M., & Speziale, P.
(2007).
Fibrinogen-binding proteins of Gram-positive bacteria. Thrombosis and Haemostasis.
98(3), 503-511.
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Dugan, T. A., Yang, V., McQuillan, D. J., & Hk, M.
(2006).
Decorin modulates fibrin assembly and structure. 281(50), 38208-38216.
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Rafii, M. S., Hagiwara, H., Mercado, M. L., Seo, N. S., Xu, T., Dugan, T., ... Fallon, J. R.
(2006).
Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development. Journal of Cellular Physiology.
209(2), 439-447.
-
Nallapareddy, S. R., Singh, K. V., Sillanp, J., Garsin, D. A., Hk, M., Erlandsen, S. L., & Murray, B. E.
(2006).
Endocarditis and biofilm-associated pili of Enterococcus faecalis. 116(10), 2799-2807.
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Sullivan, M. M., Barker, T. H., Funk, S. E., Karchin, A., Seo, N. S., Hk, M., ... Sage, E. H.
(2006).
Matricellular hevin regulates decorin production and collagen assembly. 281(37), 27621-27632.
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Han, R., Zwiefka, A., Caswell, C. C., Xu, Y. i., Keene, D. R., Lukomska, E., ... Lukomski, S.
(2006).
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Oldberg, A., Kjellen, L., & Hook, M.
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Tengblad, A., Thunberg, L., & Hook, M.
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On the molecular weight dependence of the anticoagulant activity of heparin. Upsala Journal of Medical Sciences.
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Riensenfeld, J., Hk, M., Bjrk, I., Lindahl, U., & Ajaxon, B.
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Structural requirements for the interaction of heparin with antithrombin III. FEDERATION PROCEEDINGS.
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Lindahl, U., Hk, M., Bckstrm, G., Jacobsson, I., Riesenfeld, J., Malmstrm, A., Rodn, L., & Feingold, D. S.
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Structure and biosynthesis of heparin-like polysaccharides. FEDERATION PROCEEDINGS.
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Teien, A. N., Abildgaard, U., Hook, M., & Lindahl, U.
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The activity of heparin preparations studied by amidolytic and clotting methods. Thrombosis and Haemostasis.
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Hopwood, J., Hk, M., Linker, A., & Lindahl, U.
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Lindahl, U., Jacobsson, I., Hk, M., Backstrm, G., & Feingold, D. S.
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Biosynthesis of heparin. Loss of C-5 hydrogen during conversion of D-glucuronic to L-iduronic acid residues. Biochemical and Biophysical Research Communications.
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Lindahl, U., Jacobsson, I., Hk, M., Backstrm, G., & Feingold, D. S.
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Biosynthesis of heparin. Loss of C-5 hydrogen during conversion of d-glucuronic to l-iduronic acid residues. Biochemical and Biophysical Research Communications.
70(2), 492-499.
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Wasteson, A., Hk, M., & Westermark, B.
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Demonstration of a platelet enzyme, degrading heparan sulphate. FEBS Letters.
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Teien, A. N., Abildgaard, U., & Hk, M.
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The anticoagulant effect of heparan sulfate and dermatan sulfate. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis.
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Hk, M., Wasteson, A., & Oldberg, A.
(1975).
A heparan sulfate-degrading endoglycosidase from rat liver tissue. Biochemical and Biophysical Research Communications.
67(4), 1422-1428.
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Malmstrm, A., & Fransson, L. A.
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Biosynthesis of dermatan sulfate. I. Formation of L-iduronic acid residues. Journal of Biological Chemistry.
250(9), 3419-3425.
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Bckstrom, G., Hallen, A., Hk, M., Jansson, L., & Linkahl, U.
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Biosynthesis of heparin. Advances in Experimental Medicine and Biology.
52, 61-77.
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Biosynthesis of heparin. Solubilization and partial characterization of N- and O-sulphotransferases. Biochemical Journal.
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Hk, M., Lindahl, U., Halln, A., & Bckstrm, G.
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Biosynthesis of heparin. Studies on the microsomal sulfation process. Journal of Biological Chemistry.
250(15), 6065-6071.
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Jansson, L., Hook, M., Wasteson, A., & Lindahl, U.
(1975).
Biosynthesis of heparin: solubilization and partial characterization of N and O sulphotransferases. The Italian journal of biochemistry.
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Hook, M., Lindahl, U., Hallen, A., & Backstrom, G.
(1975).
Biosynthesis of heparin: studies on the microsomal sulphation process. The Italian journal of biochemistry.
24(1), 20-21.
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Hk, M., Lindahl, U., Bckstrm, G., Malmstrm, A., & Fransson, L.
(1974).
Biosynthesis of heparin. 3. Formation of iduronic acid residues. Journal of Biological Chemistry.
249(12), 3908-3915.
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Hk, M., Lindahl, U., & Iverius, P. H.
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Distribution of sulphate and iduronic acid residues in heparin and heparan sulphate. Biochemical Journal.
137(1), 33-43.
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Pagba, C. V., Gupta, A. K., Naji, A. K., van der Hoeven, D., Churion, K., Liang, X., ... Gorfe, A. A.
(2022).
KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement. 2(6), 617-626.
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chapter
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Visai, L., Ferrari, D., Barbu, E. M., Liang, X., Ganesh, V. K., Hk, M., & Imbriani, M.
(2014).
Staphylococcal biofilm formation and development: Related diseases, host immune responses and therapy. Prokaryotes: Physiology, Biochemistry and Cell Behavior.
(pp. 1-33).
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Shinomura, T., Ito, K., & Hk, M.
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The Synthesis of Collagen Peptides and Characterization of Their Inhibitory Effects on the Collagen Binding Activities of Integrins 11 and 21. Peptides: The Wave of the Future.
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(1982).
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(1980).
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(1976).
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(pp. 13-19).
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Visai, L., Ferrari, D., Barbu, E. M., Liang, X., Ganesh, V. K., Hk, M., & Imbriani, M.
(2014).
Staphylococcal biofilm formation and development: Related diseases, host immune responses and therapy. Prokaryotes: Physiology, Biochemistry and Cell Behavior.
(pp. 1-33).
-
conference paper
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Hk, M., Smeds, E., Ganesh, V., Francis, P., Ko, Y. P., Ross, C., & Kang, M.
(2011).
MSCRAMMS in staphylococcal Bone infections. European Cells and Materials.
12.
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Francis, M. P., Vazquez, V., Vannakambadi, G., & Hk, M.
(2011).
Sequence changes in the isoforms of staphylococcal MSCRAMMs Bbp/SdrE affect ligand specificity. European Cells and Materials.
48.
-
Hk, M.
(2008).
The role of MSCRAMMs in staphylococcal skeletal infections. European Cells and Materials.
11.
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Peterson, S. B., Ferdous, Z., Hk, M., & Grande-Allen, K. J.
(2007).
Decorin Deficient Cells Demonstrate Increased Proliferation and Altered Phenotypic Properties. 985-986.
-
Simpson, K. H., Bowden, G., Hook, M., & Anvari, B.
(2003).
Optical measurements of dynamic adhesive forces between bacteria and protein-coated surfaces. Proceedings of SPIE.
263-270.
-
Simpson, K. H., Bowden, M. G., Hk, M., & Anvari, B.
(2002).
Quantification of S. aureus Adhesion to Fibronectin Using Optical Tweezers. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.
2277-2278.
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Liu, S., Zhou, F., Hk, M., & Carson, D. D.
(1997).
A heparin-binding synthetic peptide of heparin/heparan sulfate-interacting protein modulates blood coagulation activities. Proceedings of the National Academy of Sciences of the United States of America.
1739-1744.
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Zhou, F., Hk, T., Thompson, J. A., & Hk, M.
(1992).
Heparin protein interactions. Advances in Experimental Medicine and Biology.
141-153.
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Teien, A. N., Abildgaard, U., Hk, M., & Lindahl, U.
(1977).
The Activity of Heparin Preparations Studied by Amidolytic and Clotting Methods. Thrombosis and Haemostasis.
108-108.
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Hk, M., Smeds, E., Ganesh, V., Francis, P., Ko, Y. P., Ross, C., & Kang, M.
(2011).
MSCRAMMS in staphylococcal Bone infections. European Cells and Materials.
12.
-
institutional repository document
-
Bertoglio, F., Ko, Y., Thomas, S., Giordano, L., Scommegna, F. R., Meier, D., ... Visai, L.
(2022).
Antibodies to Coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared Fibrinogen binding repeats
-
DebRoy, S., Tobar, V. A., Galvez, G., Arora, S., Liang, X., Horstmann, N., ... Shelburne, S. A.
(2020).
Genome-wide analysis of in vivo CcpA binding with and without its key co-factor HPr in the major human pathogen group A Streptococcus
-
Bertoglio, F., Ko, Y., Thomas, S., Giordano, L., Scommegna, F. R., Meier, D., ... Visai, L.
(2022).
Antibodies to Coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared Fibrinogen binding repeats
-
patent
-
Hook, M., Ko, Y., Smeds, E., & Ganesh, V. K.
(2021).
Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof
-
Hook, M., Xu, X., & Kim, J.
(2019).
Specific binding sites in collagen for integrins and use thereof
-
Russell, B., Hook, M., Hahn, M., Cosgriff-hernandez, E., Seo, N., Xu, M., Rivera, J., & Browning, M.
(2017).
Designer collagens and use thereof
-
Maher, S., Schwartz, J., Hook, A., Russell, B., & Jones, C.
(2013).
Composition for the attachment of implants to collagen or other components of biological tissue
-
Russell, B., Hook, M., Hahn, M., Cosgriff-hernandez, E., Seo, N., & Xu, M.
(2013).
Designer collagens and use thereof
-
Hook, M., Ko, Y., Smeds, E., & Ganesh, V. K.
(2012).
Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof
-
Xu, X., & Kim, J.
(2012).
Specific binding sites in collagen for integrins and use thereof
-
Patti, J., House-pompeo, K., Speziale, P., Joh, D., & Mcgavin, M.
(2012).
Treatment of Staphylococcus aureus infections utilizing antibodies that bind to fibronectin binding proteins
-
Hook, M., Labandeira-rey, M., & Bowden, G.
(2012).
Antibodies recognizing a highly expressed putative antigen of CA-MRSA and methods of use
-
Hook, M., Xu, Y. i., Sillanpaa, J., Sthanam, N., Ponnuraj, K., Patti, J., ... Bowden, M.
(2010).
Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby
-
Lukomski, S., & Xu, Y. i.
(2010).
Prokaryotic collagen-like proteins and uses thereof
-
Patti, J., Foster, T., & Hook, M.
(2010).
Multicomponent vaccines
-
Rich, R. L., Kriekemeyer, B., Owens, R. T., Hook, M., Murray, B. E., Nallapareddy, S. R., & Weinstock, G. M.
(2009).
Collagen-binding proteins from enterococcal bacteria
-
Lukomski, S., & Xu, Y. i.
(2009).
Prokaryotic collagen-like proteins and uses thereof
-
Hook, M., Xu, Y. i., Sillanpaa, J., Sthanam, N., Ponnuraj, K., Patti, J., ... Bowden, M.
(2009).
Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby
-
Henry, S., Hook, M., & Mayne, R.
(2007).
Nucleotide and amino acid sequences of asporins
-
Hook, M., Xu, Y. i., Speziale, P., Visal, L., Casolini, F., Patti, J., Patel, P., & Domanski, P.
(2007).
Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use
-
Lukomski, S., & Xu, Y. i.
(2007).
Prokaryotic collagen-like proteins and uses thereof
-
Patti, J., House-pompeo, K., Speziale, P., Joh, D., & Mcgavin, M.
(2006).
Fibronectin binding protein compositions and methods of use
-
Dugan, T.
(2006).
Decorin proteoglycan inhibitor of fibrinogen blood clotting
-
Lukomski, S., & Xu, Y. i.
(2005).
Prokaryotic collagen-like proteins and uses thereof
-
Rich, R., Kriekemeyer, B., Owens, R., Hook, M., Murray, B., Nallapareddy, S., & Weinstock, G.
(2005).
Collagen-binding proteins from enterococcal bacteria
-
Davis, S., & Hook, M.
(2004).
Method and compositions for inhibiting thrombin-induced coagulation
-
Xu, Y. i., & Hook, M.
(2004).
Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
-
Patti, J., Foster, T., & Hook, M.
(2004).
Multicomponent vaccines
-
Patti, J., House-pompeo, K., Speziale, P., Joh, D., & Mcgavin, M.
(2004).
Fibronectin binding protein compositions and methods of use
-
Patti, J. M., Foster, T. J., & Hook, M.
(2004).
Multicomponent vaccines
-
Foster, T. J., Mccrea, K., Hook, M., Davis, S., Ni, E. D., & Hartford, O.
(2003).
Polypeptides and polynucleotides from coagulase-negative staphylococci
-
Hook, M., & Brown, E.
(2003).
Decorin binding protein essential peptides and methods of use
-
Hook, M., & Yang, V.
(2002).
Peptide inhibitor of fibrinogen blood clotting
-
Guo, B. P., & Hook, M.
(2001).
DbpA compositions and methods of use
-
Hook, M., Patti, J., House-pompeo, K., Sthanam, N., & Symersky, J.
(2001).
Collagen binding protein compositions and methods of use
-
Guo, B. P., & Hook, M.
(2001).
Decorin binding protein compositions and methods of use
-
Guo, B., & Hook, M.
(2001).
Decorin binding protein compositions
-
Guo, B. P., & Hook, M.
(2001).
DbpA compositions
-
Guo, B., & Hook, M.
(1998).
Decorin binding protein compositions and methods of use
-
Koo, Y., Hook, M., Arora, S., Visai, L., Bertoglio, F., Hust, M., & Meier, D.
Compositions And Use Of A Fibrinogen Binding Motif Present In EFB And COA For Therapeutics And Vaccines Against Staphylococcus Aureus
-
Hook, M., Ko, Y., Smeds, E., & Ganesh, V. K.
(2021).
Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof
Research
principal investigator on
- Analysis of Staphylococcus Aureus Host Interactions awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2020
- Analysis of Staphylococcus Aureus Host Interactions awarded by National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States) 2012 - 2016
co-principal investigator on
- Collagen Binding as a Virulence Mechanism in Lyme Borreliosis awarded by National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States) 2015 - 2018
- Multilayer Vascular Grafts Based on Collagen-Mimetic Hydrogels awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2012 - 2018
- A new mammalian-specific function for OspC in Lyme borreliosis awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2017
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BICH691 Research Instructor
- IBST691 Research Credit: Medical Sci Instructor
- MSCI689 Sptp: Foun In Biotech Instructor
- MSCI689 Sptp:starting Biotech Company Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Works By Students
chaired theses and dissertations
-
Francis, Mathew Prashanth (2015-04). Understanding the Structural Basis for Functional Differences in Staphylococcal MSCRAMMS SDRE1 and BBP/SDRE2 and Their Role in Species Tropism.
-
Kang, Mingsong (2014-08). Complement Evasion by S. aureus Surface Proteins.
Background
education and training
- Ph.D., Uppsala University - (Uppsala, Sweden) 1974
- B.S., Uppsala University - (Uppsala, Sweden) 1971
Contact
first name
- Magnus
has last name
- Hook
mailing address
-
Texas A&M Health Science Center
Ibt-Office Of The Director
1201 TAMUS
Houston, TX 77030-3303
USA
Other
- mhook@ibt.tamhsc.edu