Collagen-binding proteins from enterococcal bacteria Patent uri icon

abstract

  • A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized to inhibit adhesion of enterococcal bacteria to extracellular matrix proteins. The N-terminal region of Ace contained a region (residues 174-319), or A domain, contains several 47-residue tandem repeat units between the collagen-binding site and cell wall-associated regions. The Ace protein can be utilized in methods of preventing and/or treating enterococcal infection, and in addition, antibodies raised against Ace, or its A domain, can be used to effectively inhibit the adhesion of enterococcal cells to a collagen substrate.

author list (cited authors)

  • Rich, R. L., Kriekemeyer, B., Owens, R. T., Hook, M., Murray, B. E., Nallapareddy, S. R., & Weinstock, G. M.

complete list of authors

  • Rich, Rebecca L||Kriekemeyer, Bernd||Owens, Rick T||Hook, Magnus||Murray, Barbara E||Nallapareddy, Sreedhar R||Weinstock, George M

publication date

  • December 2009