MSCRAMM-mediated adherence of microorganisms to host tissues.

abstract

• Microbial adhesion to host tissue is the initial critical event in the pathogenesis of most infections and, as such, is an attractive target for the development of new antimicrobial therapeutics. Specific microbial components (adhesins) mediate adherence to host tissues by participating in amazingly sophisticated interactions with host molecules. This review focuses on a class of cell surface adhesins that specifically interact with extracellular matrix components and which we have designated MSCRAMMs (microbial surface components recognizing adhesive matrix molecules). MSCRAMMs recognizing fibronectin-, fibrinogen-, collagen-, and heparin-related polysaccharides are discussed in terms of structural organization, ligand-binding structures, importance in host tissue colonization and invasion, and role as virulence factors.

authors

• Hook, Magnus

published proceedings

• Annu Rev Microbiol

altmetric score

• 9

author list (cited authors)

• Patti, J. M., Allen, B. L., McGavin, M. J., & Hk, M.

citation count

• 952

complete list of authors

• Patti, JM||Allen, BL||McGavin, MJ||Höök, M

publication date

• January 1994

publisher

• Annual Reviews  Publisher

published in

• Annual Review of Microbiology  Journal

keywords

• Adhesins, Bacterial
• Amino Acid Sequence
• Bacterial Adhesion
• Extracellular Matrix Proteins
• Gram-Negative Bacteria
• Gram-Positive Bacteria
• Heparin
• Molecular Sequence Data

PubMed Central ID

• 7826020

Digital Object Identifier (DOI)

• 10.1146/annurev.mi.48.100194.003101

start page

• 585

end page

• 617

volume

• 48

issue

• 1

URL

• http://dx.doi.org/10.1146/annurev.mi.48.100194.003101