The collagen-binding adhesin is a virulence factor in Staphylococcus aureus keratitis.
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A collagen-binding strain of Staphylococcus aureus produced suppurative inflammation in a rabbit model of soft contact lens-associated bacterial keratitis more often than its collagen-binding-negative isogenic mutant. Reintroduction of the cna gene on a multicopy plasmid into the mutant helped it regain its corneal adherence and infectivity. The topical application of a collagen-binding peptide before bacterial challenge decreased S. aureus adherence to deepithelialized corneas. These data suggest that the collagen-binding adhesin is involved in the pathogenesis of S. aureus infection of the cornea.
author list (cited authors)
Rhem, M. N., Lech, E. M., Patti, J. M., McDevitt, D., Hk, M., Jones, D. B., & Wilhelmus, K. R.
complete list of authors
Rhem, MN||Lech, EM||Patti, JM||McDevitt, D||Höök, M||Jones, DB||Wilhelmus, KR
editor list (cited editors)