The collagen-binding adhesin is a virulence factor in Staphylococcus aureus keratitis. Academic Article

abstract

• A collagen-binding strain of Staphylococcus aureus produced suppurative inflammation in a rabbit model of soft contact lens-associated bacterial keratitis more often than its collagen-binding-negative isogenic mutant. Reintroduction of the cna gene on a multicopy plasmid into the mutant helped it regain its corneal adherence and infectivity. The topical application of a collagen-binding peptide before bacterial challenge decreased S. aureus adherence to deepithelialized corneas. These data suggest that the collagen-binding adhesin is involved in the pathogenesis of S. aureus infection of the cornea.

authors

• Hook, Magnus

published proceedings

• Infect Immun

author list (cited authors)

• Rhem, M. N., Lech, E. M., Patti, J. M., McDevitt, D., Hk, M., Jones, D. B., & Wilhelmus, K. R.

citation count

• 104

complete list of authors

• Rhem, MN||Lech, EM||Patti, JM||McDevitt, D||Höök, M||Jones, DB||Wilhelmus, KR

editor list (cited editors)

• Tuomanen, E. I.

publication date

• June 2000

publisher

• American Society for Microbiology  Publisher

published in

• Infection and Immunity  Journal

keywords

• Adhesins, Bacterial
• Animals
• Bacterial Adhesion
• Bacterial Proteins
• Collagen
• Eye Infections, Bacterial
• Keratitis
• Protein Binding
• Rabbits
• Species Specificity
• Staphylococcus Aureus

PubMed Central ID

• 10816547

Digital Object Identifier (DOI)

• 10.1128/IAI.68.6.3776-3779.2000

URI

• https://hdl.handle.net/1969.1/183311

start page

• 3776

end page

• 3779

volume

• 68

issue

• 6

URL

• http://dx.doi.org/10.1128/iai.68.6.3776-3779.2000