The collagen-binding adhesin is a virulence factor in Staphylococcus aureus keratitis. Academic Article uri icon


  • A collagen-binding strain of Staphylococcus aureus produced suppurative inflammation in a rabbit model of soft contact lens-associated bacterial keratitis more often than its collagen-binding-negative isogenic mutant. Reintroduction of the cna gene on a multicopy plasmid into the mutant helped it regain its corneal adherence and infectivity. The topical application of a collagen-binding peptide before bacterial challenge decreased S. aureus adherence to deepithelialized corneas. These data suggest that the collagen-binding adhesin is involved in the pathogenesis of S. aureus infection of the cornea.

published proceedings

  • Infect Immun

author list (cited authors)

  • Rhem, M. N., Lech, E. M., Patti, J. M., McDevitt, D., Hk, M., Jones, D. B., & Wilhelmus, K. R.

citation count

  • 104

complete list of authors

  • Rhem, MN||Lech, EM||Patti, JM||McDevitt, D||Höök, M||Jones, DB||Wilhelmus, KR

editor list (cited editors)

  • Tuomanen, E. I.

publication date

  • June 2000