Cold-insoluble globulin mediates the adhesion of rat liver cells to plastic Petri dishes. Academic Article uri icon


  • Adhesion of rat hepatocytes to plastic culture dishes requires a factor present in normal plasma or serum which tentatively is identified as cold-insoluble globulin since (i) cold-insoluble globulin was the only native plasma protein tested showing cell-adhesion mediating activity, and (ii) plasma from which cold-insoluble globulin selectively had been removed lost its ability to induce cell attachment. Under certain circumstances also asialoceruloplasmin became a potent cell adhesion mediating agent. However, cell attachment mediated by asialoceruloplasmin and cold-insoluble globulin, respectively, was demonstrated to involve separate mechanisms. 1977.

published proceedings

  • Biochem Biophys Res Commun

altmetric score

  • 3

author list (cited authors)

  • Hk, M., Rubin, K., Oldberg, A., Obrink, B., & Vaheri, A.

citation count

  • 136

complete list of authors

  • Höök, M||Rubin, K||Oldberg, A||Obrink, B||Vaheri, A

publication date

  • January 1977