The molecular basis of fibronectin-mediated bacterial adherence to host cells.

abstract

• Many pathogenic Gram-positive bacteria produce cell wall-anchored proteins that bind to components of the extracellular matrix (ECM) of the host. These bacterial MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) are thought to play a critical role in infection. One group of MSCRAMMs, produced by staphylococci and streptococci, targets fibronectin (Fn, a glycoprotein found in the ECM and body fluids of vertebrates) using repeats in the C-terminal region of the bacterial protein. These bacterial Fn-binding proteins (FnBPs) mediate adhesion to host tissue and bacterial uptake into non-phagocytic host cells. Recent studies on interactions between the host and bacterial proteins at the residue-specific level and on the mechanism of host cell invasion are providing a much clearer picture of these processes.

authors

• Hook, Magnus

published proceedings

• Mol Microbiol

author list (cited authors)

• Schwarz-Linek, U., Hk, M., & Potts, J. R.

citation count

• 208

complete list of authors

• Schwarz-Linek, Ulrich||Höök, Magnus||Potts, Jennifer R

publication date

• May 2004

publisher

• Wiley  Publisher

published in

• Molecular Microbiology  Journal

keywords

• Adhesins, Bacterial
• Animals
• Bacterial Adhesion
• Bacterial Proteins
• Binding Sites
• Carrier Proteins
• Extracellular Matrix
• Fibronectins
• Models, Molecular
• Protein Conformation

PubMed Central ID

• 15101971

Digital Object Identifier (DOI)

• 10.1111/j.1365-2958.2004.04027.x

start page

• 631

end page

• 641

volume

• 52

issue

• 3

URL

• http://dx.doi.org/10.1111/j.1365-2958.2004.04027.x