Multicomponent Lyme vaccine: three is not a crowd. Academic Article

abstract

• Lyme disease is caused by the spirochete Borrelia burgdorferi and it is the most common vector-borne disease in the United States. Disseminated spirochetes can persist in various tissues and can result in a variety of different disease manifestations. Vaccination trials testing various lipoprotein candidates have yielded mixed results despite the generation of robust antibody titers. Data presented in this report demonstrate that a combination vaccine composed of DbpA, BBK32 and OspC is more effective than single or double component formulations and that the ratio of each component dramatically impacts vaccine efficacy when tested in protection experiments against Borrelia following needle inoculation.

authors

• Hook, Magnus

published proceedings

• Vaccine

altmetric score

• 3

author list (cited authors)

• Brown, E. L., Kim, J. H., Reisenbichler, E. S., & Hk, M.

citation count

• 44

complete list of authors

• Brown, Eric L||Kim, Jung Hwa||Reisenbichler, Emily S||Höök, Magnus

publication date

• January 2005

publisher

• Elsevier  Publisher

published in

• Vaccine  Journal

keywords

• Adhesins, Bacterial
• Animals
• Antibodies, Bacterial
• Antigens, Bacterial
• Bacterial Outer Membrane Proteins
• Bacterial Proteins
• Borrelia Burgdorferi
• Disease Models, Animal
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunoglobulin G
• Lyme Disease
• Lyme Disease Vaccines
• Mice
• Mice, Inbred BALB C
• Vaccines, Subunit
• Vaccines, Synthetic

Digital Object Identifier (DOI)

• 10.1016/j.vaccine.2005.02.006

start page

• 3687

end page

• 3696

volume

• 23

issue

• 28

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.vaccine.2005.02.006

user-defined tag

• 3 Good Health and Well-Being