A heparan sulfate-degrading endoglycosidase from rat liver tissue. Academic Article uri icon


  • Incubation of a rat liver lysosomal fraction with [35S]heparan sulfate resulted in degradation of the polymer to oligosaccharides, demonstrating the presence of a heparan sulfate-degrading endoglycosidase. Judging from the size of the oligosaccharides, representing degradation end-products, only a limited number of the glycosidic linkages in the heparan sulfate molecule would seem to be susceptible to the heparitinase. The pH-dependence of the enzyme (active at pH 5.6; inactive at pH 3.8) was found to differ from that of liver hyaluronidase (active at pH 3.8; inactive at pH 5.6), suggesting that the heparitinase is a previously unknown enzyme. 1975.

published proceedings

  • Biochem Biophys Res Commun

altmetric score

  • 6

author list (cited authors)

  • Hk, M., Wasteson, A., & Oldberg, A.

citation count

  • 84

complete list of authors

  • Höök, M||Wasteson, A||Oldberg, A

publication date

  • January 1975