A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. Academic Article uri icon

abstract

  • Staphylococcus aureus strains isolated from patients with septic arthritis or osteomyelitis possess a collagen receptor present in two forms, which contains either two or three copies of a 187-amino-acid repeat motif. Collagen receptor-positive strains adhered to both collagen substrata and cartilage in a time-dependent process. Collagen receptor-specific antibodies blocked bacterial adherence, as did preincubation of the substrate with a recombinant form of the receptor protein. Furthermore, polystyrene beads coated with the collagen receptor bound collagen and attached to cartilage. Taken together, these results suggest that the collagen receptor is both necessary and sufficient to mediate bacterial adherence to cartilage in a process that constitutes an important part of the pathogenic mechanism in septic arthritis.

published proceedings

  • Mol Microbiol

altmetric score

  • 9

author list (cited authors)

  • Switalski, L. M., Patti, J. M., Butcher, W., Gristina, A. G., Speziale, P., & Hk, M.

citation count

  • 173

complete list of authors

  • Switalski, LM||Patti, JM||Butcher, W||Gristina, AG||Speziale, P||Höök, M

publication date

  • January 1993

publisher