Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus. Academic Article

abstract

• Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. Structural and functional analysis has identified four distinct classes of surface proteins, of which microbial surface component recognizing adhesive matrix molecules (MSCRAMMs) are the largest class. These surface proteins have numerous functions, including adhesion to and invasion of host cells and tissues, evasion of immune responses and biofilm formation. Thus, cell wall-anchored proteins are essential virulence factors for the survival of S. aureus in the commensal state and during invasive infections, and targeting them with vaccines could combat S. aureus infections.

authors

• Hook, Magnus

published proceedings

• Nat Rev Microbiol

altmetric score

• 7.25

author list (cited authors)

• Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Hk, M.

citation count

• 959

complete list of authors

• Foster, Timothy J||Geoghegan, Joan A||Ganesh, Vannakambadi K||Höök, Magnus

publication date

• January 2014

publisher

• Springer Nature  Publisher

published in

• Nature Reviews Microbiology  Journal

keywords

• Animals
• Bacterial Adhesion
• Bacterial Proteins
• Cell Wall
• Disease Models, Animal
• Host-Pathogen Interactions
• Humans
• Membrane Proteins
• Peptidoglycan
• Protein Binding
• Protein Conformation
• Staphylococcus Aureus
• Virulence Factors

Digital Object Identifier (DOI)

• 10.1038/nrmicro3161

start page

• 49

end page

• 62

volume

• 12

issue

• 1

URL

• http://dx.doi.org/10.1038/nrmicro3161