Binding of heparin on the surface of cultured human endothelial cells.

abstract

• 3H-labelled heparin was shown to bind to the surface of cultured human endothelial cells. The binding was time dependent, saturable, reversible and trypsin sensitive. The binding capacity corresponds to about 106 molecules of heparin per cell. Labelled material released from the cells retained its ability to bind to antithrombin III. Binding of heparin to endothelial cells as well as its release is suggested to be of importance in the pharmacokinetics of heparin and to influence the non-thrombogenic properties of the endothelial lining during heparin therapy. 1978.

authors

• Hook, Magnus

published proceedings

• Thromb Res

altmetric score

• 3

author list (cited authors)

• Glimelius, B., Busch, C., & Hk, M.

citation count

• 247

complete list of authors

• Glimelius, B||Busch, C||Höök, M

publication date

• January 1978

publisher

• Elsevier  Publisher

published in

• Thrombosis Research: vascular obstruction, hemorrhage and hemostasis  Journal

keywords

• Animals
• Binding Sites
• Cell Membrane
• Cells, Cultured
• Endothelium
• Heparin
• Humans
• Kinetics
• Swine
• Time Factors

Digital Object Identifier (DOI)

• 10.1016/0049-3848(78)90271-2

start page

• 773

end page

• 782

volume

• 12

issue

• 5

URL

• http://dx.doi.org/10.1016/0049-3848(78)90271-2