HR job title
- Professor
- Contact Info
- 1 979 458 1521
- Websites
- ORCiD
- 0000-0001-8569-8070
Wu, Chaodong Professor and Presidential Impact Fellow
Positions
- Professor, Texas A&M AgriLife Research, Texas A&M University
- Professor, Nutrition, College of Agriculture and Life Sciences
The long-term goal of Dr. Wu's research program is to elucidate the mechanisms underlying the pathogenesis of obesity and overnutrition-associated metabolic diseases including insulin resistance, diabetes, and fatty liver disease so that novel dietary and/or pharmacological approaches can be developed for preventing and/or treating metabolic diseases. Using molecular, cellular, and integrative approaches, the Wu lab is focused on investigating the interaction between metabolism and inflammation.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
- Contact
- Other
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Overview
Publications
selected publications
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academic article
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Kundu, D., Kennedy, L., Zhou, T., Ekser, B., Meadows, V., Sybenga, A., ... Francis, H.
(2023).
p16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling. HEPATOLOGY.
78(1), 243-257.
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Wu, N., Zhou, T., Carpino, G., Baiocchi, L., Kyritsi, K., Kennedy, L., ... Alpini, G.
(2023).
Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2 -/- mice. HEPATOLOGY.
77(6), 1849-1865.
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Slevin, E., Koyama, S., Harrison, K., Wan, Y., Klaunig, J. E., Wu, C., Shetty, A. K., & Meng, F.
(2023).
Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness. 27(7), 891-905.
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Wan, Y., Slevin, E., Koyama, S., Huang, C., Shetty, A. K., Li, X., ... Meng, F.
(2023).
miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury. Hepatology Communications.
7(4), e0089.
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Wan, Y., Zhou, T., Slevin, E., Koyama, S., Li, X., Harrison, K., ... Meng, F.
(2023).
Liver-specific deletion of microRNA-34a alleviates ductular reaction and liver fibrosis during experimental cholestasis. 37(2), e22731.
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Kyritsi, K., Wu, N., Zhou, T., Carpino, G., Baiocchi, L., Kennedy, L., ... Alpini, G.
(2023).
Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity. 13(1), 5.
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Li, H., Zheng, J., Xu, Q., Yang, Y., Zhou, J., Guo, X., ... Wu, C.
(2023).
Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation. Gastroenterology.
164(1), 134-146.
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He, L., Wang, X., Ding, Z., Liu, L., Cheng, H., Bily, D., ... Xie, L.
(2023).
Deleting Gata4 in hepatocytes promoted the progression of NAFLD via increasing steatosis and apoptosis, and desensitizing insulin signaling. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
111, 109157-109157.
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Li, H., Guo, X., Aquino, E., & Wu, C.
(2023).
Mini review: STING activation during non-alcoholic fatty liver disease. Frontiers in Nutrition.
10, 1139339.
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Liu, L., Zhou, Y. i., Liu, Z., Li, J., Hu, L., He, L., ... Xie, L.
(2023).
Osr1 Regulates Macrophage-mediated Liver Inflammation in Nonalcoholic Fatty Liver Disease Progression. CMGH Cellular and Molecular Gastroenterology and Hepatology.
15(5), 1117-1133.
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Muthyala, S., Chapkin, R. S., Wu, C., & Wu, C.
(2022).
Ghrelin Alleviates Experimental Ulcerative Colitis in Old Mice and Modulates Colonocyte Metabolism via PPAR Pathway. International Journal of Molecular Sciences.
24(1), 565-565.
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Zhu, B., Li, H., Lu, B., Guo, X., Wu, C., Wang, F., ... Wu, C.
(2022).
Indole supplementation ameliorates MCD-induced NASH in mice. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
107, 109041-109041.
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O'Brien, A., Zhou, T., White, T., Medford, A., Chen, L., Kyritsi, K., ... Glaser, S.
(2022).
FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2-/- Mouse Model of Primary Sclerosing Cholangitis. 6(7), 1574-1588.
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Wu, M., Liao, M., Huang, R., Chen, C., Tian, T., Wang, H., ... Xiao, X.
(2022).
Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. 9(2), 401-414.
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Ceci, L., Zhou, T., Lenci, I., Meadows, V., Kennedy, L., Li, P., ... Baiocchi, L.
(2022).
Molecular Mechanisms Linking Risk Factors to Cholangiocarcinoma Development. Cancers.
14(6), 1442-1442.
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Cheng, Q., Wu, C., Guo, L., & Hu, J.
(2022).
Editorial: The relationship between sarcopenia and metabolic diseases: Its formation mechanism and intervention means. Frontiers in Endocrinology.
13, 972238.
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Wan, Y., Li, X., Slevin, E., Harrison, K., Li, T., Zhang, Y., ... Meng, F.
(2022).
Endothelial dysfunction in pathological processes of chronic liver disease during aging. 36(1), e22125.
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Zhang, S., Zhao, J., Xie, F., He, H., Johnston, L. J., Dai, X., Wu, C., & Ma, X. i.
(2021).
Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease. Obesity Reviews.
22(11), e13316.
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Wang, X., Rao, H., Liu, F., Wei, L., Li, H., & Wu, C.
(2021).
Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease. Cells.
10(12), 3300-3300.
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Lin, S., Li, Y., Wang, D., Huang, C., Marino, D., Bollt, O., ... Yang, S.
(2021).
Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression. Cancer Letters.
518, 230-242.
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Matthews, D. R., Li, H., Zhou, J., Li, Q., Glaser, S., Francis, H., Alpini, G., & Wu, C.
(2021).
Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation. American Journal of Pathology.
191(10), 1743-1753.
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Lin, X., Zhang, Y., He, X., Chen, Y., Chen, N., Liu, J., ... Xiao, X.
(2021).
The Choline Metabolite TMAO Inhibits NETosis and Promotes Placental Development in GDM of Humans and Mice. Diabetes.
70(10), 2250-2263.
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Chen, L., Zhou, T., White, T., O'Brien, A., Chakraborty, S., Liangpunsakul, S., ... Glaser, S.
(2021).
The Apelin-Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis. 73(6), 2411-2428.
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Ke, S., Yu, S., Liu, D., Shi, G., Wang, M., Zhou, B., ... Qian, X.
(2021).
Ginsenoside Rb1 Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Mitochondria-Related Apoptosis through Activating SIRT3 Signalling Pathway. Chinese Journal of Integrative Medicine.
27(5), 336-344.
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Baiocchi, L., Sato, K., Ekser, B., Kennedy, L., Francis, H., Ceci, L., ... Alpini, G.
(2021).
Cholangiocarcinoma: bridging the translational gap from preclinical to clinical development and implications for future therapy. Expert Opinion on Investigational Drugs.
30(4), 365-375.
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Zhou, M., Lu, W., Li, B., Liu, X., & Li, A.
(2021).
TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs. 112(3), 1289-1299.
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Zhu, B., Guo, X., Xu, H., Jiang, B., Li, H., Wang, Y., ... Wu, C.
(2021).
Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells. 101(3), 328-340.
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Zhang, J., Zhu, S., Ma, N., Johnston, L. J., Wu, C., & Ma, X. i.
(2021).
Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation. Medicinal Research Reviews.
41(2), 1061-1088.
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Xu, H., Zhu, B., Li, H., Jiang, B., Wang, Y., Yin, Q., ... Wu, C.
(2021).
Adipocyte inducible 6-phosphofructo-2-kinase suppresses adipose tissue inflammation and promotes macrophage anti-inflammatory activation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
95, 108764-108764.
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Chen, L., Wu, N., Kennedy, L., Francis, H., Ceci, L., Zhou, T., ... Alpini, G.
(2021).
Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes. HEPATOLOGY.
74(4), 1845-1863.
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Meadows, V., Baiocchi, L., Kundu, D., Sato, K., Fuentes, Y., Wu, C., ... Francis, H.
(2021).
Biliary Epithelial Senescence in Liver Disease: There Will Be SASP. Frontiers in Molecular Biosciences.
8, 803098.
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Cao, X., Mao, M., Diao, J., Hou, Y. i., Su, H., Gan, Y., ... Xiao, X.
(2021).
Ectopic Overexpression of PPAR2 in the Heart Determines Differences in Hypertrophic Cardiomyopathy After Treatment With Different Thiazolidinediones in a Mouse Model of Diabetes. Frontiers in Pharmacology.
12, 683156.
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Zhang, W., Guo, X., Chen, L., Chen, T., Yu, J., Wu, C., & Zheng, J.
(2021).
Ketogenic Diets and Cardio-Metabolic Diseases. Frontiers in Endocrinology.
12, 753039.
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Kyritsi, K., Francis, H., Zhou, T., Ceci, L., Wu, N., Yang, Z., ... Alpini, G.
(2020).
Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2/ Mouse Model of Primary Sclerosing Cholangitis. Gene Expression: International Journal of Molecular and Cellular Science.
20(2), 89-103.
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Ceci, L., Francis, H., Zhou, T., Giang, T., Yang, Z., Meng, F., ... Alpini, G.
(2020).
Knockout of the Tachykinin Receptor 1 in the Mdr2-/- (Abcb4-/-) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis. American Journal of Pathology.
190(11), 2251-2266.
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Ma, L., Li, H., Hu, J., Zheng, J., Zhou, J., Botchlett, R., ... Wu, C.
(2020).
Indole Alleviates Diet-Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3. HEPATOLOGY.
72(4), 1191-1203.
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Hu, R., Li, X., Peng, C., Gao, R., Ma, L., Hu, J., ... Yang, S.
(2020).
miR-196b-5p-enriched extracellular vesicles from tubular epithelial cells mediated aldosterone-induced renal fibrosis in mice with diabetes. BMJ Open Diabetes Research and Care.
8(1), e001101-e001101.
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Mingjuan Deng, .., Fang Qu, .., Long Chen, .., Chang Liu, .., Ming Zhang, .., Fazheng Ren, .., ... Liang Zhao.
(2020).
SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD. 245(3), 425-437.
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Kyritsi, K., Chen, L., O'Brien, A., Francis, H., Hein, T. W., Venter, J., ... Glaser, S. S.
(2020).
Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis. HEPATOLOGY.
71(3), 990-1008.
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Shi, G., Liu, D., Zhou, B., Liu, Y., Hao, B., Yu, S., ... Qian, X.
(2020).
Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein-Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis. Journal of Cardiovascular Pharmacology.
75(2), 155-167.
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Wu, N., Baiocchi, L., Zhou, T., Kennedy, L., Ceci, L., Meng, F., ... Alpini, G.
(2020).
Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury. HEPATOLOGY.
72(6), 2219-2227.
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Wang, X., Rao, H., Zhao, J., Wee, A., Li, X., Fei, R., ... Wei, L.
(2020).
STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease. Laboratory Investigation.
100(4), 542-552.
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Jiang, X., Zheng, J., Zhang, S., Wang, B., Wu, C., & Guo, X.
(2020).
Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD. Frontiers in Medicine.
7, 361.
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Zhou, J., Li, H., Cai, Y., Ma, L., Mathews, D., Lu, B., ... Wu, C.
(2019).
Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH. Journal of Endocrinology.
243(3), 199-209.
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Xu, J., Yang, Q., Zhang, X., Liu, Z., Cao, Y., Wang, L., ... Huo, Y.
(2019).
Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance. Journal of Endocrinology.
242(2), 159-172.
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Ahmed Abdalhamid Osman, M., Sun, Y., Li, R., Lin, H., Zeng, D., Chen, X., ... Yu, X.
(2019).
Deletion of pancreatic -cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia. Journal of Cellular and Molecular Medicine.
23(7), 4653-4665.
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Zhou, Y., Zeng, X., Li, G. e., Yang, Q., Xu, J., Zhang, M., ... Huo, Y.
(2019).
Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia-induced brain injury. British Journal of Pharmacology.
176(13), 2250-2263.
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Cao, Y., Zhang, X., Wang, L., Yang, Q., Ma, Q., Xu, J., ... Huo, Y.
(2019).
PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension. Proceedings of the National Academy of Sciences of the United States of America.
116(27), 13394-13403.
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McDaniel, K., Wu, N., Zhou, T., Huang, L. i., Sato, K., Venter, J., ... Meng, F.
(2019).
Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA. 69(6), 2562-2578.
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Yang, W., Yan, H., Pan, Q., Shen, J. Z., Zhou, F., Wu, C., Sun, Y., & Guo, S.
(2019).
Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1. Journal of Endocrinology.
241(3), 265-278.
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Wan, Y., Ceci, L., Wu, N., Zhou, T., Chen, L., Venter, J., ... Glaser, S.
(2019).
Knockout of -calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes. Laboratory Investigation.
99(6), 764-776.
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Chen, L., Zhou, T., Wu, N., O'Brien, A., Venter, J., Ceci, L., ... Glaser, S.
(2019).
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis. BBA: Molecular Basis of Disease.
1865(6), 1525-1539.
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Yan, H., Yang, W., Zhou, F., Li, X., Pan, Q., Shen, Z., ... Guo, S.
(2019).
Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1. Diabetes.
68(2), 291-304.
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Ravisankar, S., Agah, S., Kim, H., Talcott, S., Wu, C., & Awika, J.
(2019).
Combined cereal and pulse flavonoids show enhanced bioavailability by downregulating phase II metabolism and ABC membrane transporter function in Caco-2 model. Food Chemistry.
279, 88-97.
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Li, X., Shi, X., Hou, Y. i., Cao, X., Gong, L., Wang, H., ... Xiao, X.
(2019).
Paternal hyperglycemia induces transgenerational inheritance of susceptibility to hepatic steatosis in rats involving altered methylation on Ppar promoter. BBA: Molecular Basis of Disease.
1865(1), 147-160.
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Xu, H., Fu, Q., Zhou, Y. i., Xue, C., Olson, P., Lynch, E. C., ... Xie, L.
(2018).
A long-term maternal diet intervention is necessary to avoid the obesogenic effect of maternal high-fat diet in the offspring. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
62, 210-220.
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Summerfield, M., Zhou, Y. i., Zhou, T., Wu, C., Alpini, G., Zhang, K. K., & Xie, L.
(2018).
A long-term maternal diet transition from high-fat diet to normal fat diet during pre-pregnancy avoids adipose tissue inflammation in next generation. PLoS ONE.
13(12), e0209053-e0209053.
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Zhang, M., Zeng, X., Yang, Q., Xu, J., Liu, Z., Zhou, Y., ... Huo, Y.
(2018).
Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE-/- (Apolipoprotein E Deficient) Mice. Arteriosclerosis, Thrombosis and Vascular Biology.
38(12), 2780-2792.
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Hu, X., Zhang, Q., Zeng, T., Zhang, J., Min, J., Tian, S., ... Chen, L.
(2018).
Not performing an OGTT results in underdiagnosis, inadequate risk assessment and probable cost increases of (pre)diabetes in Han Chinese over 40 years: a population-based prospective cohort study. Endocrine Connections.
7(12), 1507-1517.
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Pei, Y. a., Li, H., Cai, Y., Zhou, J., Luo, X., Ma, L., ... Wu, C.
(2018).
Regulation of adipose tissue inflammation by adenosine 2A receptor in obese mice. Journal of Endocrinology.
239(3), 365-376.
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Yang, Q., Xu, J., Ma, Q., Liu, Z., Sudhahar, V., Cao, Y., ... Huo, Y.
(2018).
PRKAA1/AMPK1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis. Nature Communications.
9(1), 4667.
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Hou, Y. i., Cao, X., Hu, X., Li, X., Shi, X., Wang, H., ... Xiao, X.
(2018).
CMHX008, a PPAR partial agonist, enhances insulin sensitivity with minor influences on bone loss. 5(3), 290-299.
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Wu, N., McDaniel, K., Zhou, T., Ramos-Lorenzo, S., Wu, C., Huang, L. i., ... Meng, F.
(2018).
Knockout of microRNA-21 attenuates alcoholic hepatitis through the VHL/NF-B signaling pathway in hepatic stellate cells. American Journal of Physiology - Gastrointestinal and Liver Physiology.
315(3), G385-G398.
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Ehrlich, L., O'Brien, A., Hall, C., White, T., Chen, L., Wu, N., ... Glaser, S.
(2018).
7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice. Gene Expression: International Journal of Molecular and Cellular Science.
18(3), 197-207.
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Cai, Y., Li, H., Liu, M., Pei, Y. a., Zheng, J., Zhou, J., ... Wu, C.
(2018).
Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity. HEPATOLOGY.
68(1), 48-61.
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Ma, L., Hu, J., Li, J., Yang, Y. i., Zhang, L., Zou, L., ... Yang, S.
(2018).
Bisphenol A promotes hyperuricemia via activating xanthine oxidase. The FASEB Journal.
32(2), 1007-1016.
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Hu, X., Zhang, Q., Zhang, M., Yang, X., Zeng, T., Zhang, J., ... Chen, L.
(2018).
Tannerella forsythia and coating color on the tongue dorsum, and fatty food liking associate with fat accumulation and insulin resistance in adult catch-up fat. INTERNATIONAL JOURNAL OF OBESITY.
42(2), 121-128.
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Luo, X., Li, H., Ma, L., Zhou, J., Guo, X., Woo, S., ... Wu, C.
(2018).
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice. Gastroenterology.
155(6), 1971-1984.e4.
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Zhou, T., Wu, N., Meng, F., Venter, J., Giang, T. K., Francis, H., ... Alpini, G.
(2018).
Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2-/- mice by diminishing senescence of cholangiocytes. Laboratory Investigation.
98(11), 1449-1464.
-
Wu, N., Meng, F., Zhou, T., Venter, J., Giang, T. K., Kyritsi, K., ... Franchitto, A.
(2018).
The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-1-Mediated Biliary Senescence. American Journal of Pathology.
188(10), 2264-2280.
-
Xu, Y., Wang, Y., Yan, S., Yang, Q., Zhou, Y., Zeng, X., ... Huo, Y.
(2017).
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation. Nature Communications.
8(1), 943.
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Yang, S., Zhang, A., Li, T., Gao, R., Peng, C., Liu, L., ... Li, Q.
(2017).
Dysregulated Autophagy in Hepatocytes Promotes Bisphenol A-Induced Hepatic Lipid Accumulation in Male Mice. ENDOCRINOLOGY.
158(9), 2799-2812.
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Liu, Z., Yan, S., Wang, J., Xu, Y., Wang, Y., Zhang, S., ... Huo, Y.
(2017).
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nature Communications.
8(1), 584.
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Xu, Y., Wang, Y., Yan, S., Zhou, Y., Yang, Q., Pan, Y., ... Huo, Y.
(2017).
Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis. EMBO Molecular Medicine.
9(9), 1263-1278.
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Lv, Q., Gao, R., Peng, C., Yi, J., Liu, L., Yang, S., ... Li, Q.
(2017).
Bisphenol A promotes hepatic lipid deposition involving Kupffer cells M1 polarization in male mice. 234(2), 143-154.
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Shi, X., Li, X., Hou, Y. i., Cao, X., Zhang, Y., Wang, H., ... Xiao, X.
(2017).
Paternal hyperglycemia in rats exacerbates the development of obesity in offspring. 234(2), 175-186.
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Guo, X., Shu, C., Li, H., Pei, Y. a., Woo, S., Zheng, J., ... Wu, C.
(2017).
Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation. Scientific Reports.
7(1), 6355.
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Qi, T., Chen, Y., Li, H., Pei, Y. a., Woo, S., Guo, X., ... Wu, C.
(2017).
A role for PFKFB3/iPFK2 in metformin suppression of adipocyte inflammatory responses. Journal of Molecular Endocrinology.
59(1), 49-59.
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Zheng, J., Xiao, K., Chen, L., Wu, C., Hu, X., Zeng, T., ... Li, Y.
(2017).
Insulin sensitizers improve the GLP-1 secretion and the amount of intestinal L cells on high-fat-diet-induced catch-up growth. 39-40, 82-91.
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Botchlett, R., Woo, S., Liu, M., Pei, Y. a., Guo, X., Li, H., & Wu, C.
(2017).
Nutritional approaches for managing obesity-associated metabolic diseases. 233(3), R145-R171.
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Hu, X., Zhang, Q., Zheng, J., Kong, W., Zhang, H., Zeng, T., ... Chen, L.
(2017).
Alteration of FXR phosphorylation and sumoylation in liver in the development of adult catch-up growth. Experimental Biology and Medicine.
242(3), 297-304.
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Wan, Y., McDaniel, K., Wu, N., Ramos-Lorenzo, S., Glaser, T., Venter, J., ... Meng, F.
(2017).
Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury. American Journal of Pathology.
187(12), 2788-2798.
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Wang, H., Shao, Y., Yuan, F., Feng, H., Li, N. a., Zhang, H., Wu, C., & Liu, Z.
(2017).
Fish Oil Feeding Modulates the Expression of Hepatic MicroRNAs in a Western-Style Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model. 2017, 2503847-11.
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Botchlett, R., Li, H., Guo, X., Qi, T., Zhao, J., Zheng, J., ... Wu, C.
(2016).
Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells. Scientific Reports.
6(1), 28963.
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Liu, L., Li, Q., Xiao, X., Wu, C., Gao, R., Peng, C., ... Ge, Q.
(2016).
miR-1934, downregulated in obesity, protects against low-grade inflammation in adipocytes. Molecular and Cellular Endocrinology.
428(C), 109-117.
-
Chen, L., Zhao, J., Tang, Q., Li, H., Zhang, C., Yu, R., ... Wu, C.
(2016).
PFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs. Scientific Reports.
6(1), 24324.
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Guo, T., Woo, S., Guo, X., Li, H., Zheng, J., Botchlett, R., ... Wu, C.
(2016).
Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity. Scientific Reports.
6(1), 22612.
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Zeng, T., Zhou, J., He, L., Zheng, J., Chen, L., Wu, C., & Xia, W.
(2016).
Blocking Nuclear Factor-Kappa B Protects against Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice. PLoS ONE.
11(3), e0149677-e0149677.
-
Yu, J., Marsh, S., Hu, J., Feng, W., & Wu, C.
(2016).
Gut Microbiota and Metagenomic Advancement in Digestive Disease. 2016, 4703406-2.
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Yu, J., Marsh, S., Hu, J., Feng, W., & Wu, C.
(2016).
The Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between Diet, Gut Microbiota, and Genetic Background. 2016, 2862173-13.
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Zheng, J., Woo, S., Hu, X., Botchlett, R., Chen, L., Huo, Y., & Wu, C.
(2015).
Metformin and metabolic diseases: a focus on hepatic aspects. Frontiers of Medicine.
9(2), 173-186.
-
Mashek, D. G., & Wu, C.
(2015).
MUFAs. Advances in Nutrition.
6(3), 276-277.
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Song, Z., Liu, Y., Hao, B., Yu, S., Zhang, H., Liu, D., ... Qian, X.
(2014).
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Research
principal investigator on
- ADK Regulation of Fat Metabolism and Insulin Sensitivity awarded by National Institute of Diabetes and Digestive and Kidney Diseases - (Bethesda, Maryland, United States) 2020 - 2024
- PFKFB3 control of adipocyte-macrophage crosstalk in obesity awarded by National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States) 2015 - 2020
- Novel role for adenosine kinase in the control of hepatic gluconeogenesis awarded by American Diabetes Association - (Alexandria, Virginia, United States) 2017 - 2019
- Protective role of adenosine 2A receptor in NAFLD awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2019
- Metabolic regulation of adipocyte-macrophage crosstalk in obesity awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2018
co-principal investigator on
Teaching
teaching activities
- NFSC475 Nutr & Physiolog Chem Instructor
- NFSC485 Directed Studies Instructor
- NFSC642 Nutritional Bich Ii Instructor
- NFSC681 Seminar Instructor
- NFSC685 Directed Studies Instructor
- NFSC691 Research Instructor
- NUTR470 Nutr & Physiolog Chem Instructor
- NUTR475 Nutr & Physiolog Chem Instructor
- NUTR481 Seminar Instructor
- NUTR485 Directed Studies Instructor
- NUTR491 Hnr-research Instructor
- NUTR491 Hnr-research Instructor
- NUTR642 Nutritional Bich Ii Instructor
- NUTR681 Seminar Instructor
- NUTR685 Directed Studies Instructor
- NUTR689 Sptp: Nutr Bich Metabolism Instructor
- NUTR689 Sptp: Nutr Biochem Metabolism Instructor
- NUTR689 Sptp: Nutrients Biochemistry Instructor
- NUTR691 Research Instructor
Works By Students
chaired theses and dissertations
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Botchlett, Rachel Erin (2015-11). Nutrient Regulation of PFKFB3/iPFK2 and Its Role in Regulating Diet-Induced Inflammation in Intestinal Epithelial Cells.
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Guo, Ting (2015-05). Beneficial Effects of Berberine on Nonalcoholic Fatty Liver Disease (NAFLD).
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Guo, Xin (2013-04). A Role for PFKFB3/IPFK2 in Overnutrition-Associated Adipose Tissue and Intestine Inflammatory Responses and Insulin Resistance.
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Halim, Vera (2012-02). Involvement of PFKFB3/iPFK2 in the Effects of Leucine and n-3 PUFA in Adipocytes.
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Qi, Ting (2015-08). Involvement of PFKFB3/iPFK2 in Beneficial Effects of Metformin on 3T3-L1 Adipocytes and Temporal Effects of Pioglitazone on Adipocytes.
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Woo, Shih Lung (2016-08). Beneficial Effects of Metformin in Diet-Induced Obesity Associated Non-Alcoholic Fatty Liver Disease.
Background
education and training
- Ph.D. in Medical Science, Peking University - (Beijing, Beijing, China) 1998
- M.A.Sc. in Medical Science, Tongji Hospital - (Wuhan, China) 1992
awards and honors
Contact
first name
- Chaodong
has last name
- Wu
mailing address
-
Texas A&M University
Nutrition
2253 TAMU
College Station, TX 77843-2253
USA
Other
In the News
- cdwu@tamu.edu