Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein-Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis. Academic Article uri icon

abstract

  • Oxidative low-density lipoprotein (ox-LDL) induces endothelium senescence and promotes atherosclerosis. Ginsenoside Rb1 (gRb1) has been proved to protect human umbilical vein cells (HUVECs), but its effect on ox-LDL-induced endothelium senescence and the underlying mechanism remains unknown. This study is to explore the involvement of the SIRT1/Beclin-1/autophagy axis in the effect of gRb1 on protecting endothelium against ox-LDL-induced senescence. Hyperlipidemia of Sprague Dawley rats was induced by high-fat diet, and gRb1 was intraperitoneal injected. A senescence model of HUVECs induced by ox-LDL was also established. The results showed that gRb1 alleviated hyperlipidemia-induced endothelium senescence and ox-LDL-induced HUVECs senescence. GRb1 also restored the reductions in SIRT1 and autophagy, which were involved in the anti-senescence effects. Beclin-1 acetylation was reduced, and the correlation between SIRT1 and Beclin-1 was increased by gRb1. Results of our study demonstrated the anti-senescence function of gRb1 against hyperlipidemia in the endothelium, and the underlying mechanism involves the SIRT1/Beclin-1/autophagy axis.

published proceedings

  • J Cardiovasc Pharmacol

author list (cited authors)

  • Shi, G., Liu, D., Zhou, B., Liu, Y., Hao, B., Yu, S., ... Qian, X.

citation count

  • 17

complete list of authors

  • Shi, Guangyao||Liu, Dinghui||Zhou, Bin||Liu, Yong||Hao, Baoshun||Yu, Shujie||Wu, Lin||Wang, Min||Song, Zhiming||Wu, Chaodong||Zhu, Jieming||Qian, Xiaoxian

publication date

  • February 2020