Endotoxin-induced liver injury and changes in the levels of plasma tumor necrosis factor-alpha and interleukin-6 in rabbits.

abstract

• ELISA was employed to detect changes in plasma TNF-alpha and IL-6 level in rabbits having endotoxin-induced generalized Shwartzman reaction. Liver injury was assessed by the increase of serum ALT and hepatic histopathologic changes. The results showed that plasma TNF-alpha and IL-6 levels increased remarkably 12h after intravenous injection of endotoxin twice at a 24h interval, and these changes corresponded with the degree of liver injury. Coinjection of dexamethasone and endotoxin partly prevented the elevation of TNF-alpha and IL-6 levels and reduced liver injury. These results indicated that TNF-alpha and IL-6 were involved in endotoxin-induced liver injury.

authors

• Wu, Chaodong

published proceedings

• Chin Med J (Engl)

author list (cited authors)

• Wu, C., Li, M., Chen, C., & Zhang, M.

citation count

• 1

complete list of authors

• Wu, C||Li, M||Chen, C||Zhang, M

publication date

• July 1995

published in

• Chinese Medical Journal  Journal

keywords

• Animals
• Chemical And Drug Induced Liver Injury
• Endotoxins
• Escherichia Coli
• Interleukin-6
• Liver
• Liver Diseases
• Male
• Necrosis
• Rabbits
• Tumor Necrosis Factor-alpha

PubMed Central ID

• 7555277

start page

• 548

end page

• 550

volume

• 108

issue

• 7