Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease.

abstract

• Obesity is a serious ongoing health problem that significantly increases the incidence of nonalcoholic fatty liver disease (NAFLD). During obesity, adipose tissue dysfunction is obvious and characterized by increased fat deposition (adiposity) and chronic low-grade inflammation. The latter has been implicated to critically promote the development and progression of NAFLD, whose advanced form non-alcoholic steatohepatitis (NASH) is considered one of the most common causes of terminal liver diseases. This review summarizes the current knowledge on obesity-related adipose dysfunction and its roles in the pathogenesis of hepatic steatosis and inflammation, as well as liver fibrosis. A better understanding of the crosstalk between adipose tissue and liver under obesity is essential for the development of new and improved preventive and/or therapeutic approaches for managing NAFLD.

authors

• Wu, Chaodong

published proceedings

• Cells

altmetric score

• 0.5

author list (cited authors)

• Wang, X., Rao, H., Liu, F., Wei, L., Li, H., & Wu, C.

citation count

• 14

complete list of authors

• Wang, Xiaoxiao||Rao, Huiying||Liu, Feng||Wei, Lai||Li, Honggui||Wu, Chaodong

publication date

• November 2021

publisher

• MDPI  Publisher

published in

• Cells  Journal

keywords

• Adipose Dysfunction
• Adipose Tissue
• Crosstalk
• Humans
• Inflammation
• Models, Biological
• Non-alcoholic Fatty Liver Disease
• Nonalcoholic Fatty Liver Disease (nafld)
• Obesity
• Signal Transduction

PubMed Central ID

• 34943809

Digital Object Identifier (DOI)

• 10.3390/cells10123300

start page

• 3300

end page

• 3300

volume

• 10

issue

• 12

URL

• http://dx.doi.org/10.3390/cells10123300

user-defined tag

• 3 Good Health and Well-Being