[Effects of reducing injection on plasma TNF-alpha and IL-6 levels in rabbits with endotoxin-induced DIC]. Academic Article uri icon


  • Plasma TNF-a and IL-6 levels of endotoxin-induced DIC in rabbits were measured by ELISA methods. Simultaneously, the effects of Reduqing (RDQ) on TNF-alpha and IL-6 were also studied. The results showed that TNF-alpha and IL-6 levels increased markedly in model group, which were confirmed with obvious damage of tissue or organ. Co-administration of RDQ could reduce plasma TNF-alpha and IL-6 levels, together with mild tissue or organ damage. These results indicated TNF-alpha and IL-6 might be involved in pathogenesis of endotoxin-induced DIC, RDQ might be used in preventing or treating DIC through mechanism of reducing TNF-alpha and IL-6 levels.

published proceedings

  • Zhongguo Zhong Xi Yi Jie He Za Zhi

author list (cited authors)

  • Wu, C. D., Li, M. Z., & Zhang, Y. P.

citation count

  • 1

complete list of authors

  • Wu, CD||Li, MZ||Zhang, YP

publication date

  • June 1995