HR job title
- Professor
- Contact Info
- 1 979 436 0751
- Websites
- ORCiD
- 0000-0002-2575-8761
Mitchell, Brett Professor
Positions
- Professor, Medical Physiology, College of Medicine
Our research focuses on understanding the mechanisms by which immune system activation causes organ dysfunction and various forms of hypertension.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Navaneethabalakrishnan, S., Goodlett, B. L., Smith, H. L., Montalvo, R. A., Cardenas, A., & Mitchell, B. M.
(2024).
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages. Clinical Science.
138(14), 921-940.
-
Navaneethabalakrishnan, S., Goodlett, B. L., Smith, H. L., Cardenas, A., Burns, A., & Mitchell, B. M.
(2024).
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure. Clinical Science.
138(14), 901-920.
-
Rossitto, G., Bertoldi, G., Rutkowski, J. M., Mitchell, B. M., & Delles, C.
(2024).
Sodium, Interstitium, Lymphatics, and Hypertension-A Tale of Hydraulics: Salt Series. HYPERTENSION.
-
Creed, H. A., Kannan, S., Tate, B. L., Godefroy, D., Banerjee, P., Mitchell, B. M., ... Rutkowski, J. M.
(2024).
Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury. Journal of the American Society of Nephrology.
-
Baranwal, G., Goodlett, B. L., Arenaz, C. M., Creed, H. A., Navaneethabalakrishnan, S., Rutkowski, J. M., Alaniz, R. C., & Mitchell, B. M.
(2023).
Indole Propionic Acid Increases T Regulatory Cells and Decreases T Helper 17 Cells and Blood Pressure in Mice with Salt-Sensitive Hypertension. International Journal of Molecular Sciences.
24(11), 9192-9192.
-
Goodlett, B. L., Balasubbramanian, D., Navaneethabalakrishnan, S., Love, S. E., Luera, E. M., Konatham, S., ... Mitchell, B. M.
(2022).
Genetically inducing renal lymphangiogenesis attenuates hypertension in mice. Clinical Science.
136(23), 1759-1772.
-
Sims, B. M., Goodlett, B. L., Allbee, M. L., Pickup, E. J., Chiasson, V. L., Arenaz, C. M., ... Mitchell, B. M.
(2022).
Time restricted feeding decreases renal innate immune cells and blood pressure in hypertensive mice. Journal of Hypertension.
40(10), 1960-1968.
-
Wilcox, B. K., Henley, M. R., Navaneethabalakrishnan, S., Martinez, K. A., Pournouri, A., Goodlett, B. L., ... Mitchell, B. M.
(2022).
Hypertensive Stimuli Indirectly Stimulate Lymphangiogenesis through Immune Cell Secreted Factors. 11(14), 2139-2139.
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Navaneethabalakrishnan, S., Wilcox, B. K., Goodlett, B. L., Murphy, M. M., & Mitchell, B. M.
(2022).
Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction. Clinical Science.
136(11), 879-894.
-
Smith, H., Navaneethabalakrishnan, S., Goodlett, B., & Mitchell, B. M.
(2022).
Abstract 065: Decreasing Blood Pressure In Mice With Salt-Sensitive Hypertension Changes Renal Immune Cell Populations. HYPERTENSION.
79(Suppl_1),
-
Navaneethabalakrishnan, S., Goodlett, B., Smith, H., & Mitchell, B. M.
(2022).
Abstract P086: Blood Pressure And Salt Differentially Regulate Testicular Immune Cell Populations In Hypertensive Mice. HYPERTENSION.
79(Suppl_1),
-
McDermott, J. G., Creed, H., Navaneethabalakrishnan, S., Goodlett, B., Rutkowski, J. M., & Mitchell, B. M.
(2022).
Abstract P110: Differential Gene Expression Associated With Ccn1-positive Renal Cells In Murine Hypertensive Models. HYPERTENSION.
79(Suppl_1),
-
Balasubbramanian, D., & Mitchell, B. M.
(2022).
Lymphatics in Cardiovascular Physiology. Cold Spring Harbor Perspectives in Medicine.
12(8), a041173-a041173.
-
Navaneethabalakrishnan, S., Smith, H. L., Arenaz, C. M., Goodlett, B. L., McDermott, J. G., & Mitchell, B. M.
(2022).
Update on Immune Mechanisms in Hypertension. American Journal of Hypertension.
35(10), 842-851.
-
Baranwal, G., Pilla, R., Goodlett, B., Jayaraman, A., Rutkowski, J. M., Alaniz, R., & Mitchell, B. M.
(2021).
Metabolomic Study To Identify Common Metabolites In Two Different Mouse Models Of Hypertension. HYPERTENSION.
78(Suppl_1),
-
Goodlett, B. L., Kang, C. S., Yoo, E., Navaneethabalakrishnan, S., Balasubbramanian, D., Love, S. E., ... Mitchell, B. M.
(2021).
A Kidney-Targeted Nanoparticle to Augment Renal Lymphatic Density Decreases Blood Pressure in Hypertensive Mice. Pharmaceutics.
14(1), 84-84.
-
Baranwal, G., Pilla, R., Goodlett, B. L., Coleman, A. K., Arenaz, C. M., Jayaraman, A., ... Mitchell, B. M.
(2021).
Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study. Biomolecules.
11(9), 1387-1387.
-
Navaneethabalakrishnan, S., Goodlett, B. L., Lopez, A. H., Rutkowski, J. M., & Mitchell, B. M.
(2020).
Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads. Clinical Science.
134(24), 3237-3257.
-
Balasubbramanian, D., Baranwal, G., Clark, M., Goodlett, B. L., Mitchell, B. M., & Rutkowski, J. M.
(2020).
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice. Journal of Hypertension.
38(5), 874-885.
-
Goodlett, B. L., Yoo, E., Kang, C. S., Balasubbramanian, D., Love, S., Tate, W., ... Mitchell, B. M.
(2020).
Abstract P132: A Kidney-Targeted Nanoparticle To Augment Renal Lymphatic Density Decreases Blood Pressure In Mice With L-NAME- And Angiotensin II-Induced Hypertension. HYPERTENSION.
76(Suppl_1),
-
Navaneethabalakrishnan, S., Goodlett, B. L., & Mitchell, B. M.
(2020).
Abstract P146: Testicular Inflammation Is Associated With Immune Cell Infiltration And Lymphangiogenesis In L-NAME-induced Hypertension. HYPERTENSION.
76(Suppl_1),
-
Balasubbramanian, D., Gelston, C., Lopez, A. H., Iskander, G., Tate, W., Holderness, H., Rutkowski, J. M., & Mitchell, B. M.
(2020).
Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice. American Journal of Hypertension.
33(1), 61-69.
-
Balasubbramanian, D., Lopez Gelston, C. A., Rutkowski, J. M., & Mitchell, B. M.
(2019).
Immune cell trafficking, lymphatics and hypertension. British Journal of Pharmacology.
176(12), 1978-1988.
-
Balasubbramanian, D., Goodlett, B. L., & Mitchell, B. M.
(2019).
Is IL-12 pro-inflammatory or anti-inflammatory? Depends on the blood pressure. Cardiovascular Research.
115(6), 998-999.
-
Balasubbramanian, D., Konatham, S., Iskander, G., Engelhaupt, M., Love, S., Tate, W., ... Mitchell, B. M.
(2019).
Abstract 143: Enhancing Renal Lymphatic Vessel Density Blunts Both Salt-Sensitive and Angiotensin II-Dependent Hypertension in Mice. HYPERTENSION.
74(Suppl_1),
-
Balasubbramanian, D., Luera, E. M., Goodlett, B. L., Baranwal, G., Rutkowski, J. M., & Mitchell, B. M.
(2019).
Abstract P3020: Therapeutic Induction of Renal Lymphatic Expansion Attenuates Blood Pressure in Mice With L-NAME Hypertension. HYPERTENSION.
74(Suppl_1),
-
Lopez Gelston, C. A., Balasubbramanian, D., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Rutkowski, J. M.
(2018).
Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice. Circulation Research.
122(8), 1094-1101.
-
Balasubbramanian, D., Lopez-Gelston, C. A., Lopez, A. H., Iskander, G., Tate, W., Luera, E. M., ... Mitchell, B. M.
(2018).
Abstract 024: Genetically Inducing Renal Lymphangiogenesis Prevents Angiotensin II-Induced Hypertension in Mice. HYPERTENSION.
72(Suppl_1),
-
Balasubbramanian, D., Lopez-Geslton, C. A., Ighofose, P., Saathoff, M., Rutkowski, J. M., & Mitchell, B. M.
(2018).
Abstract P166: Identification of Cyr61 and Tfgbi as Hypertensive Renal LEC Genes. HYPERTENSION.
72(Suppl_1),
-
Chatterjee, P., Chiasson, V. L., Kopriva, S. E., Bounds, K. R., Newell-Rogers, M. K., & Mitchell, B. M.
(2018).
Both maternal and placental toll-like receptor activation are necessary for the full development of proteinuric hypertension in mice. Pregnancy Hypertension.
13, 154-160.
-
Chiasson, V. L., Bounds, K. R., Chatterjee, P., Manandhar, L., Pakanati, A. R., Hernandez, M., Aziz, B., & Mitchell, B. M.
(2018).
Myeloid-Derived Suppressor Cells Ameliorate Cyclosporine A-Induced Hypertension in Mice. 71(1), 199-207.
-
Balasubbramanian, D., Lopez Gelston, C. A., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Mitchell, B. M.
(2017).
Abstract 098: Augmenting Renal Lymphatic Vessel Density Prevents Salt-sensitive Hypertension in Mice. HYPERTENSION.
70(suppl_1),
-
Chatterjee, P., Chiasson, V. L., Seerangan, G., De Guzman, E., Milad, M., Bounds, K. R., ... Mitchell, B. M.
(2017).
Depletion of MHC class II invariant chain peptide or - T-cells ameliorates experimental preeclampsia. Clinical Science.
131(15), 2047-2058.
-
Lopez Gelston, C. A., & Mitchell, B. M.
(2017).
Recent Advances in Immunity and Hypertension. American Journal of Hypertension.
30(7), 643-652.
-
Chiasson, V. L., Pakanati, A. R., Hernandez, M., Young, K. J., Bounds, K. R., & Mitchell, B. M.
(2017).
Regulatory T-Cell Augmentation or Interleukin-17 Inhibition Prevents Calcineurin Inhibitor-Induced Hypertension in Mice. HYPERTENSION.
70(1), 183-191.
-
Kneedler, S. C., Phillips, L. E., Hudson, K. R., Beckman, K. M., Lopez Gelston, C. A., Rutkowski, J. M., ... Mitchell, B. M.
(2017).
Renal inflammation and injury are associated with lymphangiogenesis in hypertension. American Journal of Physiology: Renal Physiology.
312(5), F861-F869.
-
Lopez Gelston, C. A., Balasubbramanian, D., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Mitchell, B. M.
(2017).
Abstract P339: Genetically Induced Renal Lymphangiogenesis Prevents the Development of L-NAME Hypertension in Mice. HYPERTENSION.
70(suppl_1),
-
Balasubbramanian, D., Gelston, C., Mitchell, B. M., & Chatterjee, P.
(2017).
Toll-like receptor activation, vascular endothelial function, and hypertensive disorders of pregnancy. Pharmacological Research.
121, 14-21.
-
Chatterjee, P., Chiasson, V. L., Pinzur, L., Raveh, S., Abraham, E., Jones, K. A., ... Mitchell, B. M.
(2016).
Human placenta-derived stromal cells decrease inflammation, placental injury and blood pressure in hypertensive pregnant mice. 130(7), 513-523.
-
Kneedler, S. C., Phillips, L., Hudson, K. R., Beckman, K. M., Parrish, A. R., Doris, P. A., & Mitchell, B. M.
(2016).
Abstract P145: Renal Inflammation and Injury is Associated with Increased Lymphangiogenesis in Hypertension. HYPERTENSION.
68(suppl_1),
-
Rosas, P. C., Liu, Y., Abdalla, M. I., Thomas, C. M., Kidwell, D. T., Dusio, G. F., ... Tong, C. W.
(2015).
Phosphorylation of cardiac Myosin-binding protein-C is a critical mediator of diastolic function. Circulation: Heart Failure.
8(3), 582-594.
-
Bounds, K. R., Chiasson, V. L., Tobin, R. P., Newell-Rogers, M. K., & Mitchell, B. M.
(2015).
Abstract P178: Depletion of Gamma-Delta T Cells Protects Against Toll-Like Receptor-Induced Preeclampsia in Mice. HYPERTENSION.
66(suppl_1),
-
Chiasson, V. L., Bounds, K. R., Pakanati, A. R., Aziz, B., Roman, M. H., & Mitchell, B. M.
(2015).
Abstract P183: Myeloid-Derived Suppressor Cells Prevent Cyclosporine A-Induced Hypertension, Endothelial Dysfunction, and Renal Injury in Mice. HYPERTENSION.
66(suppl_1),
-
Chatterjee, P., Chiasson, V. L., Seerangan, G., Tobin, R. P., Kopriva, S. E., Newell-Rogers, M. K., & Mitchell, B. M.
(2015).
Cotreatment with interleukin 4 and interleukin 10 modulates immune cells and prevents hypertension in pregnant mice. American Journal of Hypertension.
28(1), 135-142.
-
Bounds, K. R., Newell-Rogers, M. K., & Mitchell, B. M.
(2015).
Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia. Frontiers in Cardiovascular Medicine.
2, 20.
-
Charles, D., Jamison, A., Chiasson, V. L., Mitchell, B. M., & Chatterjee, P.
(2014).
Abstract 668: Deficiency of miR-155 Attenuates TLR3-Induced Preeclampsia-Like Symptoms in Mice. HYPERTENSION.
64(suppl_1),
-
Hatahet, M., Gasheva, O. Y., Chiasson, V. L., Chatterjee, P., Bounds, K. R., Tobin, R. P., Newell-Rogers, M. K., & Mitchell, B. M.
(2014).
Abstract 095: CD74 Deficient Mice are Resistant to Toll-Like Receptor-Induced Preeclampsia. HYPERTENSION.
64(suppl_1),
-
Bounds, K. R., Chiasson, V. L., Roman, M. H., & Mitchell, B. M.
(2014).
Abstract 459: Myeloid-Derived Suppressor Cells (MDSCs) Prevent Cyclosporine A-Induced Vascular and Renal Endothelial Cell Injury. HYPERTENSION.
64(suppl_1),
-
Chiasson, V. L., Manandhar, L., Roman, M. H., Bounds, K. R., & Mitchell, B. M.
(2014).
Abstract 460: IL-33 Treatment Prevents Cyclosporine A-Induced Hypertension, Endothelial Dysfunction, and Vascular Remodeling in Mice. HYPERTENSION.
64(suppl_1),
-
Pinzur, L., Chiasson, V., Chatterjee, P., Hatahet, M., Abraham, E., Chajut, A., Ofir, R., & Mitchell, B.
(2014).
PLX-PAD cell treatment mitigate toll-like receptor induced preeclampsia symptomology in mice. Cytotherapy.
16(4), s101-S101.
-
Chatterjee, P., Chiasson, V. L., Bounds, K. R., & Mitchell, B. M.
(2014).
Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy. Frontiers in Immunology.
5(MAY), 253-1.
-
Chatterjee, P., Kopriva, S. E., Chiasson, V. L., Young, K. J., Tobin, R. P., Newell-Rogers, K., & Mitchell, B. M.
(2013).
Interleukin-4 deficiency induces mild preeclampsia in mice. Journal of Hypertension.
31(7), 1414-1423.
-
Kopriva, S. E., Chiasson, V. L., Mitchell, B. M., & Chatterjee, P.
(2013).
TLR3-induced placental miR-210 down-regulates the STAT6/interleukin-4 pathway. PLoS ONE.
8(7), e67760-e67760.
-
Nguyen, H., Chiasson, V. L., Chatterjee, P., Kopriva, S. E., Young, K. J., & Mitchell, B. M.
(2013).
Interleukin-17 causes Rho-kinase-mediated endothelial dysfunction and hypertension. Cardiovascular Research.
97(4), 696-704.
-
Chiasson, V. L., Chatterjee, P., Hatahet, M., Pinzur, L., Abraham, E., Flaishon, L., Chajut, A., & Mitchell, B. M.
(2013).
Abstract 545: PLacental eXpanded (PLX) Cell Treatment Ameliorates Preeclampsia Induced by TLR3 or TLR7 Activation in Mice. HYPERTENSION.
62(suppl_1),
-
Chatterjee, P., Chiasson, V. L., Kopriva, S. E., & Mitchell, B. M.
(2013).
Abstract 7: Both Maternal Systemic and Paternal-Derived Placental Trophoblast TLR3 Activation Are Necessary for the Development of Preeclampsia in Mice. HYPERTENSION.
62(suppl_1),
-
Doersch, K., Chatterjee, P., Allen, S., Kopriva, S., Chiasson, V., & Mitchell, B.
(2012).
778: Excessive placental Toll-like receptor 7/8 signaling contributes to human and experimental preeclampsia. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY.
206(1), s343-S343.
-
Allen, S., Chaterjee, P., Doersch, K., Chiasson, V., Narayanan, A., Young, K., Kopriva, S., & Mitchell, B.
(2012).
796: The role of single-stranded RNA in the development of preeclampsia. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY.
206(1), s350-S350.
-
Seerangan, G., de Guzman, E. V., Chiasson, V. L., Chatterjee, P., Tobin, R. P., Young, K. J., Newell, M. K., & Mitchell, B. M.
(2012).
Abstract 173: Depletion of CLIP+ Immune Cells Prevents Toll-Like Receptor-Induced Preeclampsia in Mice. HYPERTENSION.
60(suppl_1),
-
Chatterjee, P., Chiasson, V. L., Kopriva, S. E., Weaver, L. E., & Mitchell, B. M.
(2012).
Abstract 179: TLR3 Deficiency Attenuates Preeclampsia-Like Symptoms in Mice. HYPERTENSION.
60(suppl_1),
-
Chatterjee, P., Kopriva, S. E., Chiasson, V. L., & Mitchell, B. M.
(2012).
Abstract 208: TLR3-Induced Placental miR-210 Down-Regulates the STAT6/IL-4 Pathway. HYPERTENSION.
60(suppl_1),
-
Chiasson, V. L., Chatterjee, P., Young, K. J., Kopriva, S. E., & Mitchell, B. M.
(2012).
Abstract 448: Cyclosporine A-Induced Increases in Th17 Cells, Endothelial Dysfunction, and Blood Pressure are Prevented by IL-17 Inhibition. HYPERTENSION.
60(suppl_1),
-
Chiasson, V. L., Jones, K. A., Kopriva, S. E., Mahajan, A., Young, K. J., & Mitchell, B. M.
(2012).
Endothelial cell transforming growth factor- receptor activation causes tacrolimus-induced renal arteriolar hyalinosis. Kidney International.
82(8), 857-866.
-
Chatterjee, P., Chiasson, V. L., Kopriva, S. E., Young, K. J., Chatterjee, V., Jones, K. A., & Mitchell, B. M.
(2011).
Interleukin 10 deficiency exacerbates toll-like receptor 3-induced preeclampsia-like symptoms in mice. 58(3), 489-496.
-
Chiasson, V. L., Munshi, N., Chatterjee, P., Young, K. J., & Mitchell, B. M.
(2011).
Pin1 deficiency causes endothelial dysfunction and hypertension. 58(3), 431-438.
-
Chiasson, V. L., Talreja, D., Young, K. J., Chatterjee, P., Banes-Berceli, A. K., & Mitchell, B. M.
(2011).
FK506 binding protein 12 deficiency in endothelial and hematopoietic cells decreases regulatory T cells and causes hypertension. 57(6), 1167-1175.
-
Chiasson, V. L., Quinn, M. A., Young, K. J., & Mitchell, B. M.
(2011).
Protein kinase CbetaII-mediated phosphorylation of endothelial nitric oxide synthase threonine 495 mediates the endothelial dysfunction induced by FK506 (tacrolimus). Journal of Pharmacology and Experimental Therapeutics.
337(3), 718-723.
-
Chatterjee, P., Chiasson, V., Young, K., & Mitchell, B.
(2011).
742: IL-4 KO mice exhibit gestational hypertension which is augmented following dsRNA-induced maternal immune system activation. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY.
204(1), s292-S292.
-
Weaver, L., Chatterjee, P., Lopez, M., Chiasson, V., Young, K., & Mitchell, B.
(2011).
769: Activation of double-stranded rna receptors contributes to preeclampsia. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY.
204(1), s302-S302.
-
Chatterjee, P., Weaver, L. E., Chiasson, V. L., Young, K. J., & Mitchell, B. M.
(2011).
Do double-stranded RNA receptors play a role in preeclampsia?. Placenta.
32(3), 201-205.
-
Tinsley, J. H., South, S., Chiasson, V. L., & Mitchell, B. M.
(2010).
Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
298(3), R713-R719.
-
Horvat, D., Severson, J., Uddin, M. N., Mitchell, B., & Puschett, J. B.
(2010).
Resibufogenin prevents the manifestations of preeclampsia in an animal model of the syndrome. Hypertension in Pregnancy.
29(1), 1-9.
-
Tinsley, J. H., Chiasson, V. L., Mahajan, A., Young, K. J., & Mitchell, B. M.
(2009).
Toll-like receptor 3 activation during pregnancy elicits preeclampsia-like symptoms in rats. American Journal of Hypertension.
22(12), 1314-1319.
-
Tinsley, J. H., Chiasson, V. L., South, S., Mahajan, A., & Mitchell, B. M.
(2009).
Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension. American Journal of Hypertension.
22(10), 1107-1114.
-
Horvat, D., Severson, J., Uddin, M., Mitchell, B., & Puschett, J.
(2009).
Resibufogenin Prevents the Manifestations of Preeclampsia in an Animal Model of the Syndrome. Hypertension in Pregnancy.
1-9.
-
Cook, L. G., Chiasson, V. L., Long, C., Wu, G., & Mitchell, B. M.
(2009).
Tacrolimus reduces nitric oxide synthase function by binding to FKBP rather than by its calcineurin effect. Kidney International.
75(7), 719-726.
-
DeMorrow, S., Francis, H., Gaudio, E., Venter, J., Franchitto, A., Kopriva, S., ... Alpini, G.
(2008).
The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. American Journal of Physiology - Gastrointestinal and Liver Physiology.
295(6), G1150-G1158.
-
Uddin, M. N., Horvat, D., Glaser, S. S., Mitchell, B. M., & Puschett, J. B.
(2008).
Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function. Journal of Biological Chemistry.
283(26), 17946-17953.
-
Harris, M. B., Mitchell, B. M., Sood, S. G., Webb, R. C., & Venema, R. C.
(2008).
Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise. European Journal of Applied Physiology.
104(5), 795-802.
-
Uddin, M. N., Horvat, D., Glaser, S. S., Danchuk, S., Mitchell, B. M., Sullivan, D. E., Morris, C. A., & Puschett, J. B.
(2008).
Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells. Placenta.
29(3), 266-273.
-
Mitchell, B. M., Cook, L. G., Danchuk, S., & Puschett, J. B.
(2007).
Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension. American Journal of Hypertension.
20(12), 1297-1304.
-
Long, C., Cook, L. G., Wu, G., & Mitchell, B. M.
(2007).
Removal of FKBP12/12.6 from endothelial ryanodine receptors leads to an intracellular calcium leak and endothelial dysfunction. Arteriosclerosis, Thrombosis and Vascular Biology.
27(7), 1580-1586.
-
Long, C., Cook, L. G., Hamilton, S. L., Wu, G., & Mitchell, B. M.
(2007).
FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure. HYPERTENSION.
49(3), 569-576.
-
Mitchell, B. M., Wallerath, T., & Frstermann, U.
(2007).
Animal models of hypertension. Methods in Molecular Medicine.
139, 105-111.
-
Mitchell, B. M., & Cook, L. G.
(2007).
Displacement of FKBP12 and 12.6 from ryanodine receptors abolishes endothelial nitric oxide production and augments blood pressure. The FASEB Journal.
21(6), a862-a862.
-
Kannankeril, P. J., Mitchell, B. M., Goonasekera, S. A., Chelu, M. G., Zhang, W., Sood, S., ... Hamilton, S. L.
(2006).
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America.
103(32), 12179-12184.
-
Mitchell, B. M., Garcia, R., & Hamilton, S. L.
(2006).
Altered FKBP12/12.6 decreases NO production by increasing cPKCmediated phosphorylation of eNOS at thr495. The FASEB Journal.
20(4), a719-a719.
-
Waters, W. W., Platts, S. H., Mitchell, B. M., Whitson, P. A., & Meck, J. V.
(2005).
Plasma volume restoration with salt tablets and water after bed rest prevents orthostatic hypotension and changes in supine hemodynamic and endocrine variables. American Journal of Physiology. Heart and Circulatory Physiology.
288(2), H839-H847.
-
Platts, S. H., Ziegler, M. G., Waters, W. W., Mitchell, B. M., & Meck, J. V.
(2004).
Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension. Aviation, Space, and Environmental Medicine.
75(6), 554-556.
-
Mitchell, B. M., Dorrance, A. M., Mack, E. A., & Webb, R. C.
(2004).
Glucocorticoids decrease GTP cyclohydrolase and tetrahydrobiopterin-dependent vasorelaxation through glucocorticoid receptors. Journal of Cardiovascular Pharmacology.
43(1), 8-13.
-
Mitchell, B. M., Dorrance, A. M., & Webb, R. C.
(2004).
Phenylalanine improves dilation and blood pressure in GTP cyclohydrolase inhibition-induced hypertensive rats. Journal of Cardiovascular Pharmacology.
43(6), 758-763.
-
Mitchell, B. M., Dorrance, A. M., Ergul, A., & Webb, R. C.
(2004).
Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension. Journal of Cardiovascular Pharmacology.
43(1), 93-98.
-
Mitchell, B. M., & Meck, J. V.
(2004).
Short-duration spaceflight does not prolong QTc intervals in male astronauts. AMERICAN JOURNAL OF CARDIOLOGY.
93(8), 1051-1052.
-
Mitchell, B. M., Dorrance, A. M., & Webb, R. C.
(2003).
GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats. American Journal of Physiology. Heart and Circulatory Physiology.
285(5), H2165-H2170.
-
Mitchell, B. M., Strasburger, J. F., Hubbard, J. E., & Wessel, H. U.
(2003).
Serial exercise performance in children with surgically corrected congenital aortic stenosis. 24(4), 319-324.
-
Mitchell, B. M., & Webb, R. C.
(2002).
Impaired vasodilation and nitric oxide synthase activity in glucocorticoid-induced hypertension. Biological Research for Nursing.
4(1), 16-21.
-
Mitchell, B. M., Gutin, B., Kapuku, G., Barbeau, P., Humphries, M. C., Owens, S., Vemulapalli, S., & Allison, J.
(2002).
Left ventricular structure and function in obese adolescents: relations to cardiovascular fitness, percent body fat, and visceral adiposity, and effects of physical training. Pediatrics.
109(5), E73-E73.
-
Smith, H. L., Goodlett, B. L., Navaneethabalakrishnan, S., & Mitchell, B. M.
Elevated Salt or Angiotensin II Levels Induce CD38+ Innate Immune Cells in the Presence of Granulocyte-Macrophage Colony Stimulating Factor. Cells.
13(15), 1302-1302.
-
Balasubbramanian, D., Dharani, S., Tauseef, M., Khan, M. A., Rahman, Z., & Mitchell, B. M.
High Dose Vardenafil Blunts the Hypertensive Effects of Toll-Like Receptor 3 Activation During Pregnancy. 1, 780298.
-
Navaneethabalakrishnan, S., Goodlett, B. L., Smith, H. L., Montalvo, R. A., Cardenas, A., & Mitchell, B. M.
(2024).
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages. Clinical Science.
138(14), 921-940.
-
conference paper
-
Wilcox, B. K., Navaneethabalakrishnan, S., Martinez, K. A., Pournouri, A., Henley, M. R., Goodlett, B. L., ... Mitchell, B. M.
(2021).
Hypertensive Stimuli Indirectly Stimulate Mouse Mesometrial Lymphangiogenesis Through Immune Cells. HYPERTENSION.
-
Navaneethabalakrishnan, S., Wilcox, B. K., Goodlett, B. L., & Mitchell, B. M.
(2021).
Imbalance Of M1/M2 Macrophages In Ovaries Of Hypertensive Mice Is Associated With Reproductive Dysfunction And Lymphangiogenesis. HYPERTENSION.
-
Arenaz, C. M., Baranwal, G., Goodlett, B. L., Rutkowski, J. M., Alaniz, R. C., & Mitchell, B. M.
(2021).
Microbiome-associated Metabolites Are Altered In Mouse Models Of Hypertension. HYPERTENSION.
-
Goodlett, B. L., Sims, B. M., Navaneethabalakrishnan, S., Wilcox, B. K., Pickup, E. J., Henley, M. R., ... Mitchell, B. M.
(2021).
Time-restricted Feeding Attenuates Hypertension In Mice. HYPERTENSION.
-
Navaneethabalakrishnan, S., Wilcox, B. K., Goodlett, B. L., & Mitchell, B. M.
(2021).
Altered Testicular Macrophage Polarization Is Associated With Reproductive Dysfunction In Hypertensive Mice. HYPERTENSION.
-
Balasubbramanian, D., Luera, E. M., Goodlett, B. L., Baranwal, G., Rutkowski, J. M., & Mitchell, B. M.
(2019).
Therapeutic Induction of Renal Lymphatic Expansion Attenuates Blood Pressure in Mice With L-NAME Hypertension. HYPERTENSION.
-
Balasubbramanian, D., Konatham, S., Iskander, G., Engelhaupt, M., Love, S., Tate, W., ... Mitchell, B. M.
(2019).
Enhancing Renal Lymphatic Vessel Density Blunts Both Salt-Sensitive and Angiotensin II-Dependent Hypertension in Mice. HYPERTENSION.
-
Balasubbramanian, D., Lopez-Gelston, C. A., Lopez, A. H., Iskander, G., Tate, W., Luera, E. M., ... Mitchell, B. M.
(2018).
Genetically Inducing Renal Lymphangiogenesis Prevents Angiotensin II-Induced Hypertension in Mice. HYPERTENSION.
-
Balasubbramanian, D., Lopez-Geslton, C. A., Ighofose, P., Saathoff, M., Rutkowski, J. M., & Mitchell, B. M.
(2018).
Identification of Cyr61 and Tfgbi as Hypertensive Renal LEC Genes. HYPERTENSION.
-
Balasubbramanian, D., Lopez Gelston, C. A., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Mitchell, B. M.
(2017).
Augmenting Renal Lymphatic Vessel Density Prevents Salt-sensitive Hypertension in Mice. HYPERTENSION.
-
Gelston, L., Balasubbramanian, D., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Mitchell, B. M.
(2017).
Genetically Induced Renal Lymphangiogenesis Prevents the Development of L-NAME Hypertension in Mice. HYPERTENSION.
-
Kneedler, S. C., Phillips, L., Hudson, K. R., Beckman, K. M., Parrish, A. R., Doris, P. A., & Mitchell, B. M.
(2016).
Renal Inflammation and Injury is Associated with Increased Lymphangiogenesis in Hypertension. HYPERTENSION.
-
Rosas, P. C., Dusio, G., Liu, Y., Abdalla, M., Weber, D., Mitchell, B., & Tong, C.
(2015).
CARDIAC MYOSIN BINDING PROTEIN-C PHOSPHORYLATION ENHANCES DIASTOLIC FUNCTION DESPITE AGING. Journal of the American College of Cardiology.
A956-A956.
-
Aziz, B., Chiasson, V., Foster, K., & Mitchell, B.
(2015).
MYELOID-DERIVED SUPPRESSOR CELLS (MDSCS) PREVENT CYCLOSPORINE A-INDUCED HYPERTENSION AND VASCULAR AND RENAL TOXICITY. AMERICAN JOURNAL OF KIDNEY DISEASES.
A21-A21.
-
Charles, D., Jamison, A., Chiasson, V. L., Mitchell, B. M., & Chatterjee, P.
(2014).
Deficiency of miR-155 Attenuates TLR3-Induced Preeclampsia-Like Symptoms in Mice. HYPERTENSION.
-
Chiasson, V. L., Manandhar, L., Roman, M. H., Bounds, K. R., & Mitchell, B. M.
(2014).
IL-33 Treatment Prevents Cyclosporine A-Induced Hypertension, Endothelial Dysfunction, and Vascular Remodeling in Mice. HYPERTENSION.
-
Bounds, K. R., Chiasson, V. L., Roman, M. H., & Mitchell, B. M.
(2014).
Myeloid-Derived Suppressor Cells (MDSCs) Prevent Cyclosporine A-Induced Vascular and Renal Endothelial Cell Injury. HYPERTENSION.
-
Chatterjee, P., Chiasson, V. L., Kopriva, S. E., & Mitchell, B. M.
(2013).
Both Maternal Systemic and Paternal-Derived Placental Trophoblast TLR3 Activation Are Necessary for the Development of Preeclampsia in Mice. HYPERTENSION.
-
Chiasson, V. L., Chatterjee, P., Hatahet, M., Pinzur, L., Abraham, E., Flaishon, L., Chajut, A., & Mitchell, B. M.
(2013).
PLacental eXpanded (PLX) Cell Treatment Ameliorates Preeclampsia Induced by TLR3 or TLR7 Activation in Mice. HYPERTENSION.
-
Chatterjee, P., Kopriva, S. E., Chiasson, V. L., Young, K. J., & Mitchell, B. M.
(2011).
Combined Interleukin-4 and Interleukin-10 Treatment Prevents Preeclampsia in Mice. HYPERTENSION.
E92-E93.
-
Chatterjee, P., Kopriva, S. E., Chiasson, V. L., Young, K. J., & Mitchell, B. M.
(2011).
Double-Stranded RNA Receptor Activation Causes Preeclampsia and Decreases NFAT5 Expression by Increasing Placental miRNA-210. HYPERTENSION.
E172-E172.
-
Chiasson, V. L., Chatterjee, P., Kopriva, S. E., Young, K. J., & Mitchell, B. M.
(2011).
Genetic Deletion of Interleukin-4 or Interleukin-10 Causes Preeclampsia by Differentially Modulating Immune Cells in Mice. HYPERTENSION.
E41-E41.
-
Chiasson, V. L., Young, K. J., Chatterjee, P., Kopriva, S. E., & Mitchell, B. M.
(2011).
Retinoic Acid Prevents the Hypertension, Endothelial Dysfunction, and Decrease in Regulatory T Cells Caused by Immunosuppressive Drugs. HYPERTENSION.
E133-E133.
-
Chiasson, V. L., Quinn, M. A., Young, K. J., Chatterjee, P., & Mitchell, B. M.
(2010).
Interleukin-17 Causes Endothelial Dysfunction by Increasing Rho Kinase-Mediated Phosphorylation of eNOS Thr495. HYPERTENSION.
E54-E54.
-
Chatterjee, P., Chiasson, V. L., Young, K. J., & Mitchell, B. M.
(2010).
Similar Placental miRNA Expression Profiles in Mice with Toll-Like Receptor 3-Induced Gestational Hypertension and Women with Preeclampsia. HYPERTENSION.
E166-E166.
-
Chiasson, V. L., Quinn, M. A., Young, K. J., & Mitchell, B. M.
(2010).
FK506 Induces Renal Arteriolar Hyalinosis via SMAD2/3 Activation in Mice. HYPERTENSION.
E141-E141.
-
Chiasson, V. L., Mahajan, A., Young, K. J., Tinsley, J. H., Jones, K. A., & Mitchell, B. M.
(2009).
Endothelial Cell-Specific Genetic Deletion of FKBP12 Leads to Vascular TGF-beta Receptor Activation, Remodeling, Inflammation, and Hypertension. HYPERTENSION.
E46-E46.
-
Chiasson, V. L., Munshi, N., Young, K. J., Tinsley, J. H., & Mitchell, B. M.
(2009).
Inhibition of the Prolyl Isomerase Pin1 Increases eNOS Ser116 Phosphorylation, Endothelial Dysfunction, and Blood Pressure. HYPERTENSION.
E95-E95.
-
Tinsley, J. H., South, S. M., Chiasson, V. L., & Mitchell, B. M.
(2009).
Interleukin-10 Treatment Ameliorates DOCA/Salt-Induced Preeclampsia-Like Symptoms in Rats. HYPERTENSION.
E43-E43.
-
Tinsley, J. H., South, S. M., Chiasson, V. L., Young, K. J., & Mitchell, B. M.
(2009).
Toll-Like Receptor 3 Activation Induces Hypertension and Endothelial Dysfunction Only in Pregnant Mice. HYPERTENSION.
E90-E90.
-
Mitchell, B. M., & Chiasson, V. L.
(2008).
The immunophilin inhibitor juglone decreases NO bioavailability and vasodilation by inhibiting glutathione S-transferase. The FASEB Journal.
964.26-964.26.
-
Uddin, M. N., Horvat, D., Mitchell, B. M., & Puschett, J. B.
(2008).
Alteration of the renin-angiotensin system in a rat model of preeclampsia. HYPERTENSION.
E125-E125.
-
Tinsley, J. H., Chiasson, V. L., & Mitchell, B. M.
(2008).
Immunosuppression ameliorates hypertension, endothelial dysfunction, and proteinuria in a rat model of preeclampsia. HYPERTENSION.
E119-E119.
-
Chiasson, V. L., & Mitchell, B. M.
(2008).
The immunosuppressive drugs rapamycin and FK506 decrease vasodilation by increasing PKCbetaI-mediated phosphorylation of eNOS Thr495. The FASEB Journal.
964.32-964.32.
-
Mitchell, B. M., Cook, L. G., Long, C., & Wu, G.
(2007).
Mechanisms of FK506-induced decrease in nitric oxide production and endothelial function. HYPERTENSION.
E104-E104.
-
Mitchell, B. M., Danila, C. I., Tang, W., & Hamilton, S. L.
(2005).
Decreased endothelium-dependent relaxation and altered eNOS in FKBP12.6 deficient mice. The FASEB Journal.
A1241-A1241.
-
Mitchell, B. M., Waters, W. W., & Meck, J. V.
(2004).
Fludrocortisone does not attenuate bedrest-induced orthostatic hypotension. The FASEB Journal.
A1206-A1206.
-
Harris, M. B., Mitchell, B. M., Blackstone, M. A., Sood, S. G., Webb, R. C., & Venema, R. C.
(2004).
Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise. The FASEB Journal.
A753-A754.
-
Platts, S. H., Waters, W. W., Mitchell, B., & Meck, J. V.
(2004).
Midodrine prevents post-spaceflight orthostatic intolerance when administered 1 hour before tilt test. The FASEB Journal.
A1207-A1207.
-
Mitchell, B. M., Dorrance, A. M., & Webb, R. C.
(2003).
GTP cyclohydrolase 1 downregulation contributes to glucocorticoid hypertension in rats. HYPERTENSION.
669-674.
-
Mitchell, B. M., Smith, A. D., Webb, R. C., & Dorrance, A. M.
(2003).
Aldosterone decreases endothelium-dependent relaxation by down-regulating GTP cyclohydrolase. HYPERTENSION.
435-435.
-
Chatterjee, P., Chiasson, V. L., Young, K. J., & Mitchell, B. M.
Interleukin-4 Treatment Prevents Toll-Like Receptor 3-Induced Gestational Hypertension and Endothelial Dysfunction in Mice. HYPERTENSION.
E115-E115.
-
Wilcox, B. K., Navaneethabalakrishnan, S., Martinez, K. A., Pournouri, A., Henley, M. R., Goodlett, B. L., ... Mitchell, B. M.
(2021).
Hypertensive Stimuli Indirectly Stimulate Mouse Mesometrial Lymphangiogenesis Through Immune Cells. HYPERTENSION.
-
patent
-
Newell-rogers, M., Mitchell, B., & Newell, E.
(2016).
Methods and products for treating preeclampsia and modulating blood pressure
-
Newell-rogers, M., Mitchell, B., & Newell, E.
(2016).
Methods and products for treating preeclampsia and modulating blood pressure
Research
principal investigator on
- Texas A&M College of Medicine Developing and Readying Underrepresented Minority Researchers (DRUMR) Summer Research Program awarded by National Institute of Diabetes and Digestive and Kidney Diseases - (Bethesda, Maryland, United States) 2020 - 2025
- Role of renal lymphatics in blood pressure regulation awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2023
- Determining how microbiota-derived tryptophan metabolites regulate lymphocyte function in hypertension awarded by American Heart Association - (New York, New York, United States) 2019 - 2021
- Texas A&M Health Science Center Summer Research Program-AHA SURF Program awarded by American Heart Association - (New York, New York, United States) 2017 - 2020
- Renal Lymphatics in Hypertension awarded by American Heart Association - (New York, New York, United States) 2018 - 2019
- Role of Immune Cells in Immunosuppressive Drug-Induced Hypertension awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2015
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- GENE491 Hnr-research Instructor
- MEID704 Renal/genitourinary Instructor
- MSCI602 Contemp Top In Adv Cell Bio Ii Instructor
- MSCI681 Sem:medical School Preparation Instructor
- MSCI681 Seminar Instructor
- MSCI685 Directed Studies Instructor
- MSCI689 Sptp: Clinical Encounters Instructor
- MSCI689 Sptp: Intro Phys Exam&pati Com Instructor
- MSCI689 Sptp: Peta Pre-med Instructor
- MSCI691 Research Credit: Medical Sci Instructor
- NUTR491 Hnr-research Instructor
Background
education and training
- Ph.D. in Physiology, Augusta University - (Augusta, Georgia, United States) 2003
- M.S. in Physiology, University of Wisconsin-Extension - (Madison, Wisconsin, United States) 1996
- B.A. in Health Fitness and Biology, Gustavus Adolphus College - (Saint Peter, Minnesota, United States) 1995
awards and honors
- Distinguished Alumni Award - Graduate School, conferred by Augusta University - (Augusta, Georgia, United States), 2018
- Established Professional/Research Career Enhancement Awards, conferred by American Physiological Society - (Bethesda, Maryland, United States), 2009
- Cardiovascular Section Awards/Young Investigator Award, conferred by American Physiological Society - (Bethesda, Maryland, United States), 2005
Contact
first name
- Brett
has last name
- Mitchell
mailing address
-
Texas A&M Health Science Center
Medical Physiology
MREBII, 2412
Bryan, TX 77807
USA
Other
- brettmitchell@tamu.edu