Immune cell trafficking, lymphatics and hypertension. Academic Article uri icon


  • Activated immune cell infiltration into organs contributes to the development and maintenance of hypertension. Studies targeting specific immune cell populations or reducing their inflammatory signalling have demonstrated a reduction in BP. Lymphatic vessels play a key role in immune cell trafficking and in resolving inflammation, but little is known about their role in hypertension. Studies from our laboratory and others suggest that inflammation-associated or induction of lymphangiogenesis is organ protective and anti-hypertensive. This review provides the basis for hypertension as a disease of chronic inflammation in various tissues and highlights how renal lymphangiogenesis is a novel regulator of kidney health and BP. LINKED ARTICLES: This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit

published proceedings

  • Br J Pharmacol

author list (cited authors)

  • Balasubbramanian, D., Lopez Gelston, C. A., Rutkowski, J. M., & Mitchell, B. M.

citation count

  • 13

complete list of authors

  • Balasubbramanian, Dakshnapriya||Lopez Gelston, Catalina A||Rutkowski, Joseph M||Mitchell, Brett M

publication date

  • June 2019