HR job title
- Director of the Division of Lymphatic Biology/Department of Medical Physiology
- Contact Info
- 1 979 845 7816
- Websites
Rutkowski, Joseph Assistant Professor
Positions
- Assistant Professor, Medical Physiology, School of Medicine
Current ongoing projects are mostly focused on the Lymphatic Physiology of Metabolic Systems. Herein, we are utilizing an extensive toolkit of genetic mouse models and physiologically-relevant in vitro systems to identify how changes in lymphatic biology impact metabolite transport and whole animal metabolism. Other projects use our toolkit in identifying factors driving the pathology of lymphatic diseases such as generalized lymphatic anomalies (GLA) and lymphedema. Additional collaborative efforts employ our models in renal and pulmonary health.
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Verissimo, T., Dalga, D., Arnoux, G., Sakhi, I., Faivre, A., Auwerx, H., ... de Seigneux, S.
(2023).
PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells. American Journal of Physiology: Renal Physiology.
324(6), F532-F543.
-
Faivre, A., Dissard, R., Kuo, W., Verissimo, T., Legouis, D., Arnoux, G., ... de Seigneux, S.
(2023).
Evolution of hypoxia and hypoxia-inducible factor asparaginyl hydroxylase (FIH) regulation in chronic kidney disease. Nephrology Dialysis Transplantation.
gfad075.
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Chakraborty, S., Dixon, B. J., Rutkowski, J. M., Castorena-Gonzalez, J. A., & Breslin, J. W.
(2023).
Lymphatic Pathophysiology. Microcirculation.
30(2-3), e12806.
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An, Y. A., Xiong, W., Chen, S., Bu, D., Rutkowski, J. M., Berger, J. P., ... Scherer, P. E.
(2023).
Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model. 69, 101680-101680.
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Phan, T. T., Chakraborty, A., Tatum, M. A., Lima-Orellana, A., Reyna, A. J., & Rutkowski, J. M.
(2023).
Increased adipose tissue lymphatic vessel density inhibits thermogenesis through elevated neurotensin levels. Frontiers in Cell and Developmental Biology.
11, 1100788.
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Goodlett, B. L., Balasubbramanian, D., Navaneethabalakrishnan, S., Love, S. E., Luera, E. M., Konatham, S., ... Mitchell, B. M.
(2022).
Genetically inducing renal lymphangiogenesis attenuates hypertension in mice. Clinical Science.
136(23), 1759-1772.
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Verissimo, T., Faivre, A., Rinaldi, A., Lindenmeyer, M., Delitsikou, V., Veyrat-Durebex, C., ... de Seigneux, S.
(2022).
Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease. Journal of the American Society of Nephrology.
33(4), 810-827.
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Ghnenis, A. B., Jones, C., Sefiani, A., Douthitt, A. J., Reyna, A. J., Rutkowski, J. M., & Geoffroy, C. G.
(2022).
Evaluation of the Cardiometabolic Disorders after Spinal Cord Injury in Mice. 11(4), 495-495.
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McDermott, J. G., Creed, H., Navaneethabalakrishnan, S., Goodlett, B., Rutkowski, J. M., & Mitchell, B. M.
(2022).
Abstract P110: Differential Gene Expression Associated With Ccn1-positive Renal Cells In Murine Hypertensive Models. HYPERTENSION.
79(Suppl_1),
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Duhon, B. H., Phan, T. T., Taylor, S. L., Crescenzi, R. L., & Rutkowski, J. M.
(2022).
Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and Fibrosis. International Journal of Molecular Sciences.
23(12), 6621-6621.
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Creed, H. A., Sanfelippo, A. N., Reyna, A. J., Chakraborty, A., & Rutkowski, J. M.
(2022).
Impact of High Fat Diet and Bolus Feeding on Chyle Accumulation in a Mouse Model of Generalized Lymphatic Anomaly. Lymphatic Research and Biology.
20(4), 358-367.
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Chakraborty, A., Crescenzi, R., Usman, T. A., Reyna, A. J., Garza, M. E., Al-Ghadban, S., ... Rutkowski, J. M.
(2022).
Indications of Peripheral Pain, Dermal Hypersensitivity, and Neurogenic Inflammation in Patients with Lipedema. International Journal of Molecular Sciences.
23(18), 10313-10313.
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Goldberg, A. R., Ferguson, M., Pal, S., Cohen, R., Orlicky, D. J., McCullough, R. L., ... Tamburini, B.
(2022).
Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin. 13, 1021038.
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Baranwal, G., Pilla, R., Goodlett, B., Jayaraman, A., Rutkowski, J. M., Alaniz, R., & Mitchell, B. M.
(2021).
Metabolomic Study To Identify Common Metabolites In Two Different Mouse Models Of Hypertension. HYPERTENSION.
78(Suppl_1),
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Baranwal, G., Creed, H. A., Cromer, W. E., Wang, W., Upchurch, B. D., Smithhart, M. C., ... Rutkowski, J. M.
(2021).
Dichotomous effects on lymphatic transport with loss of caveolae in mice. Acta Physiologica.
232(4), e13656.
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Creed, H. A., & Rutkowski, J. M.
(2021).
Emerging roles for lymphatics in acute kidney injury: Beneficial or maleficent?. Experimental Biology and Medicine.
246(7), 845-850.
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Goodlett, B. L., Kang, C. S., Yoo, E., Navaneethabalakrishnan, S., Balasubbramanian, D., Love, S. E., ... Mitchell, B. M.
(2021).
A Kidney-Targeted Nanoparticle to Augment Renal Lymphatic Density Decreases Blood Pressure in Hypertensive Mice. Pharmaceutics.
14(1), 84-84.
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Chakraborty, A., Upadhya, R., Usman, T. A., Shetty, A. K., & Rutkowski, J. M.
(2021).
Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress. Brain, Behavior, and Immunity.
98, 219-233.
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Baranwal, G., Pilla, R., Goodlett, B. L., Coleman, A. K., Arenaz, C. M., Jayaraman, A., ... Mitchell, B. M.
(2021).
Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study. Biomolecules.
11(9), 1387-1387.
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Kothmann, K. H., Kay, M., Romney, S. E., Acebo, S., Reyna, A. J., Choudhury, M., Rutkowski, J. M., & Newell-Fugate, A. E.
(2021).
DHT Differentially Regulates T Helper Cell Related Cytokines and MicroRNAs In Visceral and Subcutaneous Adipose Tissue of Female Mice. Journal of the Endocrine Society.
5(Supplement_1), a764-a764.
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Baranwal, G., Creed, H. A., Black, L. M., Auger, A., Quach, A. M., Vegiraju, R., ... Rutkowski, J. M.
(2021).
Expanded renal lymphatics improve recovery following kidney injury. Physiological Reports.
9(22), e15094.
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Rutkowski, J. M.
(2021).
Fixing lymphatics improves glucose metabolism. Nature Metabolism.
3(9), 1139-1141.
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Faivre, A., Katsyuba, E., Verissimo, T., Lindenmeyer, M., Rajaram, R. D., Naesens, M., ... de Seigneux, S.
(2021).
Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease. Nephrology Dialysis Transplantation.
36(1), 60-68.
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Navaneethabalakrishnan, S., Goodlett, B. L., Lopez, A. H., Rutkowski, J. M., & Mitchell, B. M.
(2020).
Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads. Clinical Science.
134(24), 3237-3257.
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Balasubbramanian, D., Baranwal, G., Clark, M., Goodlett, B. L., Mitchell, B. M., & Rutkowski, J. M.
(2020).
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice. Journal of Hypertension.
38(5), 874-885.
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Delitsikou, V., Jarad, G., Rajaram, R. D., Ino, F., Rutkowski, J. M., Chen, C., ... de Seigneux, S.
(2020).
Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress. The FASEB Journal.
34(2), 2087-2104.
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Dizin, E., Olivier, V., Maire, C., Komarynets, O., Sassi, A., Roth, I., ... Feraille, E.
(2020).
Time-course of sodium transport along the nephron in nephrotic syndrome: The role of potassium. The FASEB Journal.
34(2), 2408-2424.
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Goodlett, B. L., Yoo, E., Kang, C. S., Balasubbramanian, D., Love, S., Tate, W., ... Mitchell, B. M.
(2020).
Abstract P132: A Kidney-Targeted Nanoparticle To Augment Renal Lymphatic Density Decreases Blood Pressure In Mice With L-NAME- And Angiotensin II-Induced Hypertension. HYPERTENSION.
76(Suppl_1),
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Baranwal, G., Upchurch, B., Cromer, W., Smithhart, M., Vadlamani, S., Clark, M., ... Rutkowski, J.
(2020).
Loss of Caveolin-1 Increases Macromolecule Transport Across Lymphatic Endothelium. The FASEB Journal.
34(S1), 1-1.
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Balasubbramanian, D., Gelston, C., Lopez, A. H., Iskander, G., Tate, W., Holderness, H., Rutkowski, J. M., & Mitchell, B. M.
(2020).
Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice. American Journal of Hypertension.
33(1), 61-69.
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Chakraborty, A., Scogin, C. K., Rizwan, K., Morley, T. S., & Rutkowski, J. M.
(2020).
Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D. Frontiers in Physiology.
11, 363.
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Baranwal, G., & Rutkowski, J. M.
(2019).
Reduced lymphatic function contributes to age-related disease. Aging.
11(22), 9969-9970.
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Balasubbramanian, D., Lopez Gelston, C. A., Rutkowski, J. M., & Mitchell, B. M.
(2019).
Immune cell trafficking, lymphatics and hypertension. British Journal of Pharmacology.
176(12), 1978-1988.
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Balasubbramanian, D., Konatham, S., Iskander, G., Engelhaupt, M., Love, S., Tate, W., ... Mitchell, B. M.
(2019).
Abstract 143: Enhancing Renal Lymphatic Vessel Density Blunts Both Salt-Sensitive and Angiotensin II-Dependent Hypertension in Mice. HYPERTENSION.
74(Suppl_1),
-
Balasubbramanian, D., Luera, E. M., Goodlett, B. L., Baranwal, G., Rutkowski, J. M., & Mitchell, B. M.
(2019).
Abstract P3020: Therapeutic Induction of Renal Lymphatic Expansion Attenuates Blood Pressure in Mice With L-NAME Hypertension. HYPERTENSION.
74(Suppl_1),
-
C, C., N, J., JM, R., M, K., F, Z., DA, T., R, G., & PE, S.
(2019).
An endothelial-to-adipocyte extracellular vesicle axis governed by metabolic state
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Chakraborty, A. A., Rizwan, K., Khetan, J. N., Scogin, C. K., & Rutkowski, J. M.
(2019).
Characterization of Lymphangiogenesis in Adipose Tissue Upon Local, Induced VEGFD Overexpression. The FASEB Journal.
33(S1), 520.2-520.2.
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Chakraborty, A., Barajas, S., Lammoglia, G. M., Reyna, A. J., Morley, T. S., Johnson, J. A., Scherer, P. E., & Rutkowski, J. M.
(2019).
Vascular Endothelial Growth Factor-D(VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity. American Journal of Pathology.
189(4), 924-939.
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Crewe, C., Joffin, N., Rutkowski, J. M., Kim, M., Zhang, F., Towler, D. A., Gordillo, R., & Scherer, P. E.
(2018).
An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State. Cell.
175(3), 695-708.e13.
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Lopez Gelston, C. A., Balasubbramanian, D., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Rutkowski, J. M.
(2018).
Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice. Circulation Research.
122(8), 1094-1101.
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Hominick, D., Silva, A., Khurana, N., Liu, Y., Dechow, P. C., Feng, J. Q., ... Dellinger, M. T.
(2018).
VEGF-C promotes the development of lymphatics in bone and bone loss. eLife.
7, e34323.
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Balasubbramanian, D., Lopez-Gelston, C. A., Lopez, A. H., Iskander, G., Tate, W., Luera, E. M., ... Mitchell, B. M.
(2018).
Abstract 024: Genetically Inducing Renal Lymphangiogenesis Prevents Angiotensin II-Induced Hypertension in Mice. HYPERTENSION.
72(Suppl_1),
-
Chakraborty, A., Lammoglia, G. M., & Rutkowski, J. M.
(2018).
Inducible Adipose Tissue VEGFD Drives Lymphatic Expansion and Improves Systemic Insulin Sensitivity in Obesity. The FASEB Journal.
32(S1), 576.2-576.2.
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Balasubbramanian, D., Lopez Gelston, C. A., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Mitchell, B. M.
(2017).
Abstract 098: Augmenting Renal Lymphatic Vessel Density Prevents Salt-sensitive Hypertension in Mice. HYPERTENSION.
70(suppl_1),
-
Nitschk, M., Bell, A., Karaman, S., Amouzgar, M., Rutkowski, J. M., Scherer, P. E., Alitalo, K., & McDonald, D. M.
(2017).
Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. American Journal of Pathology.
187(9), 1984-1997.
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Kneedler, S. C., Phillips, L. E., Hudson, K. R., Beckman, K. M., Lopez Gelston, C. A., Rutkowski, J. M., ... Mitchell, B. M.
(2017).
Renal inflammation and injury are associated with lymphangiogenesis in hypertension. American Journal of Physiology: Renal Physiology.
312(5), F861-F869.
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Abouelkheir, G. R., Upchurch, B. D., & Rutkowski, J. M.
(2017).
Lymphangiogenesis: fuel, smoke, or extinguisher of inflammation's fire?. Experimental Biology and Medicine.
242(8), 884-895.
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Lopez Gelston, C. A., Balasubbramanian, D., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Mitchell, B. M.
(2017).
Abstract P339: Genetically Induced Renal Lymphangiogenesis Prevents the Development of L-NAME Hypertension in Mice. HYPERTENSION.
70(suppl_1),
-
Rutkowski, J. M., Pastor, J., Sun, K., Park, S. K., Bobulescu, I. A., Chen, C. T., Moe, O. W., & Scherer, P. E.
(2017).
Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression. Kidney International.
91(2), 324-337.
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Udit, S., Burton, M., Rutkowski, J. M., Lee, S., Bookout, A. L., Scherer, P. E., Elmquist, J. K., & Gautron, L.
(2017).
Nav1.8 neurons are involved in limiting acute phase responses to dietary fat. Molecular Metabolism.
6(10), 1081-1091.
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Lammoglia, G. M., Van Zandt, C. E., Galvan, D. X., Orozco, J. L., Dellinger, M. T., & Rutkowski, J. M.
(2016).
Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D. American Journal of Physiology. Heart and Circulatory Physiology.
311(2), H384-H394.
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Haas, M. E., Levenson, A. E., Sun, X., Liao, W., Rutkowski, J. M., de Ferranti, S. D., ... Biddinger, S. B.
(2016).
The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation.
134(1), 61-72.
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Stern, J. H., Rutkowski, J. M., & Scherer, P. E.
(2016).
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk. Cell Metabolism.
23(5), 770-784.
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Wernstedt Asterholm, I., Kim-Muller, J. Y., Rutkowski, J. M., Crewe, C., Tao, C., & Scherer, P. E.
(2016).
Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in Retnl (RELM) Null Mice: A Model of Intestinal Immune System Dysfunction in Disease Susceptibility. American Journal of Pathology.
186(9), 2404-2416.
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de Seigneux, S., Courbebaisse, M., Rutkowski, J. M., Wilhelm-Bals, A., Metzger, M., Khodo, S. N., ... Feraille, E.
(2015).
Proteinuria Increases Plasma Phosphate by Altering Its Tubular Handling. 26(7), 1608-1618.
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Rutkowski, J. M., Stern, J. H., & Scherer, P. E.
(2015).
The cell biology of fat expansion. The Journal of Cell Biology.
208(5), 501-512.
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Rutkowski, J. M., Halberg, N., Wang, Q. A., Holland, W. L., Xia, J. Y., & Scherer, P. E.
(2014).
Differential transendothelial transport of adiponectin complexes. Cardiovascular Diabetology.
13(1), 47.
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Asterholm, I. W., Rutkowski, J. M., Fujikawa, T., Cho, Y., Fukuda, M., Tao, C., ... Scherer, P. E.
(2014).
Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia.
57(6), 1209-1218.
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Rutkowski, J. M., & Scherer, P. E.
(2014).
Isolation and quantitation of adiponectin higher order complexes. 537, 243-259.
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Murano, I., Rutkowski, J. M., Wang, Q. A., Cho, Y., Scherer, P. E., & Cinti, S.
(2013).
Time course of histomorphological changes in adipose tissue upon acute lipoatrophy. Nutrition, Metabolism and Cardiovascular Diseases.
23(8), 723-731.
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Platt, A. M., Rutkowski, J. M., Martel, C., Kuan, E. L., Ivanov, S., Swartz, M. A., & Randolph, G. J.
(2013).
Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia. Journal of Immunology.
190(9), 4608-4620.
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Rutkowski, J. M., Wang, Z. V., Park, A., Zhang, J., Zhang, D., Hu, M. C., ... Scherer, P. E.
(2013).
Adiponectin promotes functional recovery after podocyte ablation. 24(2), 268-282.
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Gautron, L., Rutkowski, J. M., Burton, M. D., Wei, W., Wan, Y., & Elmquist, J. K.
(2013).
Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen. The Journal of Comparative Neurology.
521(16), 3741-3767.
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Rutkowski, J. M., Ihm, J. E., Lee, S. T., Kilarski, W. W., Greenwood, V. I., Pasquier, M. C., ... Swartz, M. A.
(2013).
VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy. American Journal of Pathology.
183(5), 1596-1607.
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Thomas, S. N., Rutkowski, J. M., Pasquier, M., Kuan, E. L., Alitalo, K., Randolph, G. J., & Swartz, M. A.
(2012).
Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage. Journal of Immunology.
189(5), 2181-2190.
-
Asterholm, I. W., McDonald, J., Blanchard, P., Sinha, M., Xiao, Q., Mistry, J., ... Scherer, P. E.
(2012).
Lack of "immunological fitness" during fasting in metabolically challenged animals. 53(7), 1254-1267.
-
Rutkowski, J. M., Santiag, L. Y., Ben-Jebria, A., & Ultman, J. S.
(2011).
Comparison of ozone-specific (OZAC) and oxygen radical (ORAC) antioxidant capacity assays for use with nasal lavage fluid. Toxicology in Vitro.
25(7), 1406-1413.
-
Fischer-Posovszky, P., Wang, Q. A., Asterholm, I. W., Rutkowski, J. M., & Scherer, P. E.
(2011).
Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Molecular Endocrinology.
152(8), 3074-3081.
-
Holland, W. L., Miller, R. A., Wang, Z. V., Sun, K., Barth, B. M., Bui, H. H., ... Scherer, P. E.
(2011).
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nature Medicine.
17(1), 55-63.
-
Miteva, D. O., Rutkowski, J. M., Dixon, J. B., Kilarski, W., Shields, J. D., & Swartz, M. A.
(2010).
Transmural flow modulates cell and fluid transport functions of lymphatic endothelium. 106(5), 920-931.
-
Rutkowski, J. M., Markhus, C. E., Gyenge, C. C., Alitalo, K., Wiig, H., & Swartz, M. A.
(2010).
Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema. American Journal of Pathology.
176(3), 1122-1129.
-
Rutkowski, J. M., & Scherer, P. E.
(2010).
Transendothelial Transport May Determine Adiponectin Oligomer Functions. The FASEB Journal.
24(S1), 975.17-975.17.
-
Rutkowski, J. M., Davis, K. E., & Scherer, P. E.
(2009).
Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue. The FEBS Journal.
276(20), 5738-5746.
-
Dixon, J. B., Rutkowski, J. M., Randolph, G., & Swartz, M. A.
(2009).
ACTIVE REGULATION OF LIPID TRANSPORT AND METABOLISM BY LYMPHATICS: COMPLIMENTARY IN VIVO AND IN VITRO STUDIES. The FASEB Journal.
23(S1), 813.2-813.2.
-
Lim, H. Y., Rutkowski, J. M., Helft, J., Reddy, S. T., Swartz, M. A., Randolph, G. J., & Angeli, V.
(2009).
Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration. American Journal of Pathology.
175(3), 1328-1337.
-
Swartz, M. A., Rutkowski, J., Miteva, D. O., Issa, A., & Dixon, J. B.
(2008).
Molecular and biophysical regulators of lymphatic transport. The FASEB Journal.
22(S1), 392.5-392.5.
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Goldman, J., Rutkowski, J. M., Shields, J. D., Pasquier, M. C., Cui, Y., Schmkel, H. G., ... Swartz, M. A.
(2007).
Errata. The FASEB Journal.
21(8), 1942-1942.
-
Goldman, J., Conley, K. A., Raehl, A., Bondy, D. M., Pytowski, B., Swartz, M. A., ... Ongstad, E. L.
(2007).
Regulation of lymphatic capillary regeneration by interstitial flow in skin. American Journal of Physiology. Heart and Circulatory Physiology.
292(5), H2176-H2183.
-
Goldman, J., Rutkowski, J. M., Shields, J. D., Pasquier, M. C., Cui, Y., Schmkel, H. G., ... Swartz, M. A.
(2007).
Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis. The FASEB Journal.
21(4), 1003-1012.
-
Rutkowski, J. M., Yong, C., & Swartz, M. A.
(2007).
Active response of the lymphatic endothelium to acute inflammation vs. chronic lymphedema: in vivo and in vitro studies. The FASEB Journal.
21(6), a848-a849.
-
Ihm, J., Rutkowski, J. M., Lee, S., Hubbell, J. A., & Swartz, M. A.
(2007).
Lymphangiogenesis in the ovary: importance in follicle maturation and murine pregnancy. Fertility and Sterility.
88, s73-S73.
-
Rutkowski, J. M., & Swartz, M. A.
(2007).
A driving force for change: interstitial flow as a morphoregulator. Trends in Cell Biology.
17(1), 44-50.
-
Rutkowski, J. M., Boardman, K. C., & Swartz, M. A.
(2006).
Characterization of lymphangiogenesis in a model of adult skin regeneration. American Journal of Physiology. Heart and Circulatory Physiology.
291(3), H1402-H1410.
-
Rutkowski, J. M., Moya, M., Johannes, J., Goldman, J., & Swartz, M. A.
(2006).
Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9. Microvascular Research.
72(3), 161-171.
-
Rutkowski, J. M., Santiago, L. Y., Ben-Jebria, A., & Ultman, J. S.
(2003).
Development of an assay for ozone-specific antioxidant capacity. Inhalation Toxicology.
15(13), 1369-1385.
-
Creed, H., Sanfelippo, A., Chakraborty, A., & Rutkowski, J.
Impact of Dietary Fatty Acids on Chylous Effusion in a Mouse Model of Generalized Lymphatic Anomaly. The FASEB Journal.
35(S1),
-
Verissimo, T., Dalga, D., Arnoux, G., Sakhi, I., Faivre, A., Auwerx, H., ... de Seigneux, S.
(2023).
PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells. American Journal of Physiology: Renal Physiology.
324(6), F532-F543.
-
conference paper
-
Faivre, A., Dissard, R., Kuo, W., Verissimo, T., Legouis, D., Arnoux, G., ... De Seigneux, S.
(2022).
The role of hypoxia-inducible factor asparaginyl hydroxylase (FIH) in chronic kidney disease. Swiss Medical Weekly.
19S-19S.
-
Arenaz, C. M., Baranwal, G., Goodlett, B. L., Rutkowski, J. M., Alaniz, R. C., & Mitchell, B. M.
(2021).
Microbiome-associated Metabolites Are Altered In Mouse Models Of Hypertension. HYPERTENSION.
-
Balasubbramanian, D., Luera, E. M., Goodlett, B. L., Baranwal, G., Rutkowski, J. M., & Mitchell, B. M.
(2019).
Therapeutic Induction of Renal Lymphatic Expansion Attenuates Blood Pressure in Mice With L-NAME Hypertension. HYPERTENSION.
-
Balasubbramanian, D., Konatham, S., Iskander, G., Engelhaupt, M., Love, S., Tate, W., ... Mitchell, B. M.
(2019).
Enhancing Renal Lymphatic Vessel Density Blunts Both Salt-Sensitive and Angiotensin II-Dependent Hypertension in Mice. HYPERTENSION.
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Balasubbramanian, D., Lopez-Gelston, C. A., Lopez, A. H., Iskander, G., Tate, W., Luera, E. M., ... Mitchell, B. M.
(2018).
Genetically Inducing Renal Lymphangiogenesis Prevents Angiotensin II-Induced Hypertension in Mice. HYPERTENSION.
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Balasubbramanian, D., Lopez-Geslton, C. A., Ighofose, P., Saathoff, M., Rutkowski, J. M., & Mitchell, B. M.
(2018).
Identification of Cyr61 and Tfgbi as Hypertensive Renal LEC Genes. HYPERTENSION.
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Lammoglia, G. M., Barajas, S. E., Reyna, A. J., & Rutkowski, J. M.
(2017).
Adipose Tissue VEGF-D Overexpression Increases Lymphatic Vessel Density and Protects Against Inflammation and Insulin Resistance in Obesity. The FASEB Journal.
-
Balasubbramanian, D., Lopez Gelston, C. A., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Mitchell, B. M.
(2017).
Augmenting Renal Lymphatic Vessel Density Prevents Salt-sensitive Hypertension in Mice. HYPERTENSION.
-
Gelston, L., Balasubbramanian, D., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Mitchell, B. M.
(2017).
Genetically Induced Renal Lymphangiogenesis Prevents the Development of L-NAME Hypertension in Mice. HYPERTENSION.
-
Rutkowski, J. M.
(2016).
A Novel Mouse Model of Inducible Lymphangiogenesis Through Controlled Local Expression of VEGF-D. The FASEB Journal.
-
Rutkowski, J. M., & Swartz, M. A.
(2008).
Intravital quantification of tissue fluid balance changes in Lymphedema
-
Faivre, A., Dissard, R., Kuo, W., Verissimo, T., Legouis, D., Arnoux, G., ... De Seigneux, S.
(2022).
The role of hypoxia-inducible factor asparaginyl hydroxylase (FIH) in chronic kidney disease. Swiss Medical Weekly.
19S-19S.
-
institutional repository document
-
Olivier, V., Arnoux, G., Ramakrishnan, S., Sassi, A., Roth, I., Chassot, A., ... Feraille, E.
(2022).
Increased severity of chronic kidney disease in response to high potassium intake is dependent on mineralocorticoid receptor activation
-
Olivier, V., Sassi, A., Arnoux, G., Chambrey, R., Roth, I., Chassot, A., ... Ramakrishnan, S. K.
(2022).
Claudin-4, a core component of the tight-junctional complex along the collecting system, is induced in nephrotic syndrome
-
Olivier, V., Arnoux, G., Ramakrishnan, S., Sassi, A., Roth, I., Chassot, A., ... Feraille, E.
(2022).
Increased severity of chronic kidney disease in response to high potassium intake is dependent on mineralocorticoid receptor activation
Research
principal investigator on
- Lymphatics and lymphangiogenesis in kidney function and inflammation awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2020 - 2024
- Adipose tissue lymphatic vessel functions in obesity awarded by American Heart Association - (New York, New York, United States) 2017 - 2019
investigator on
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BIMS291 Research Instructor
- GENE491 Hnr-research Instructor
- MPHY635 Lymphatics Immunol Inflamm Instructor
- MPHY681 Seminar Instructor
- MPHY689 Sptp:lymphatics Immu & Inflam Instructor
- MSCI681 Seminar Instructor
- MSCI684 Professional Internship Instructor
- MSCI685 Directed Studies Instructor
- MSCI691 Research Credit: Medical Sci Instructor
- NFSC491 Research Instructor
- PHIL491 Hnr-research Instructor
Background
education and training
- Ph.D. in Bioengineering and Biotechnology, ecole Polytechnique Federale de Lausanne - (Lausanne, Switzerland) 2008
- M.S. in Chemical Engineering, Northwestern University - (Evanston, Illinois, United States) 2003
- B.S. in Chemical Engineering, Pennsylvania State University - (State College, Pennsylvania, United States) 2001
- The University of Texas Southwestern Medical Center - (Dallas, Texas, United States) , Postdoctoral Training 2012
Contact
first name
- Joseph
has last name
- Rutkowski
mailing address
-
Texas A&M Health Science Center
Medical Physiology
1114 TAMUS
College Station, TX 77843-1114
USA
Other
- rutkowski@tamu.edu