Current ongoing projects are mostly focused on the Lymphatic Physiology of Metabolic Systems. Herein, we are utilizing an extensive toolkit of genetic mouse models and physiologically-relevant in vitro systems to identify how changes in lymphatic biology impact metabolite transport and whole animal metabolism. Other projects use our toolkit in identifying factors driving the pathology of lymphatic diseases such as generalized lymphatic anomalies (GLA) and lymphedema. Additional collaborative efforts employ our models in renal and pulmonary health.