Recent Advances in Immunity and Hypertension Academic Article uri icon

abstract

  • Persistent immune system activation plays an important role in the development of various forms of hypertension. Activation of the innate immune system, inflammation, and subsequent adaptive immune system response causing end-organ injury and dysfunction ultimately leads to hypertension and its associated sequelae including coronary artery disease, heart failure, stroke, and chronic kidney disease. In this review, we will provide updates on the innate and adaptive immune cells involved in hypertension, the current understanding of how the immune system gets activated, and examine the recently discovered mechanisms involved in several forms of experimental hypertension.

altmetric score

  • 0.5

author list (cited authors)

  • Gelston, C., & Mitchell, B. M.

citation count

  • 14

publication date

  • July 2017