Recent Advances in Immunity and Hypertension. Academic Article

abstract

• Persistent immune system activation plays an important role in the development of various forms of hypertension. Activation of the innate immune system, inflammation, and subsequent adaptive immune system response causing end-organ injury and dysfunction ultimately leads to hypertension and its associated sequelae including coronary artery disease, heart failure, stroke, and chronic kidney disease. In this review, we will provide updates on the innate and adaptive immune cells involved in hypertension, the current understanding of how the immune system gets activated, and examine the recently discovered mechanisms involved in several forms of experimental hypertension.

authors

• Mitchell, Brett

published proceedings

• Am J Hypertens

altmetric score

• 0.5

author list (cited authors)

• Lopez Gelston, C. A., & Mitchell, B. M.

citation count

• 18

complete list of authors

• Lopez Gelston, Catalina A||Mitchell, Brett M

publication date

• July 2017

publisher

• Oxford University Press (OUP)  Publisher

published in

• American Journal of Hypertension  Journal

keywords

• Adaptive Immunity
• Angiotensin II
• Animals
• Blood Pressure
• Disease Models, Animal
• Humans
• Hypertension
• Hypertension, Pregnancy-Induced
• Immune System
• Immunity
• Immunity, Innate
• Inflammation
• Inflammation Mediators
• Lymphocytes
• Rats, Inbred SHR
• Risk Factors
• Signal Transduction
• Sodium Chloride, Dietary

PubMed Central ID

• 28200062

Digital Object Identifier (DOI)

• 10.1093/ajh/hpx011

start page

• 643

end page

• 652

volume

• 30

issue

• 7

URL

• http://dx.doi.org/10.1093/ajh/hpx011