Animal models of hypertension. Academic Article uri icon


  • Hypertension affects approximately 25% of adults and is a major risk factor for cardiovascular disease. Although there are currently adequate therapeutic options for humans with hypertension, the molecular mechanisms underlying hypertension are still relatively unknown. The generation of hypertensive animal models provides an excellent modality to not only study the pathophysiology but also test innovative therapeutics. This chapter describes the detailed methods that utilize the drinking water of rats to develop models of nitric oxide synthase (NOS) inhibition-induced, guanosine triphosphate cyclohydrolase (GTPCH) inhibition-induced, and glucocorticoid-induced hypertension.

published proceedings

  • Methods Mol Med

author list (cited authors)

  • Mitchell, B. M., Wallerath, T., & Frstermann, U.

citation count

  • 3

complete list of authors

  • Mitchell, Brett M||Wallerath, Thomas||F√∂rstermann, Ulrich

publication date

  • January 2007