HR job title
- Associate Professor
- Contact Info
- 1 979 458 3599
Tian, Yanan Associate Professor
Positions
- Associate Professor, Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences
Transcriptional control of the Ah receptor-regulated gene expression. Interaction between the Ah receptor and NF-kB signal transduction pathways. lncRNAs and their role in regulation of gene expression
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Overview
Publications
selected publications
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academic article
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Fang, X., Ni, N., Wang, X., Tian, Y., Ivanov, I., Rijnkels, M., ... Li, Q.
(2022).
EZH2 and Endometrial Cancer Development: Insights from a Mouse Model. 11(5), 909-909.
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Chen, J., Tang, S., Ke, S., Cai, J. J., Osorio, D., Golovko, A., ... Tian, Y.
(2022).
Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice. Redox Biology.
54, 102377-102377.
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Wang, H., Liu, Y., Guo, Z., Wu, K., Zhang, Y., Tian, Y., Zhao, B., & Lu, H.
(2022).
Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line. Research in Veterinary Science.
143, 124-133.
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Niu, X., Wu, T., Li, G., Gu, X., Tian, Y., & Cui, H.
(2022).
Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance. International Journal of Biological Sciences.
18(2), 742-759.
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Osorio, D., Zhong, Y., Li, G., Xu, Q., Yang, Y., Tian, Y., ... Cai, J. J.
(2022).
scTenifoldKnk: An efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation. Patterns.
3(3), 100434-100434.
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Pradhan, G., Wu, C., Villarreal, D., Lee, J. H., Han, H. W., Gaharwar, A., ... Sun, Y.
(2021).
Cell GHS-R Regulates Insulin Secretion and Sensitivity. International Journal of Molecular Sciences.
22(8), 3950-3950.
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Osorio, D., Zhong, Y., Li, G., Xu, Q., Yang, Y., Tian, Y., ... Cai, J. J.
(2021).
scTenifoldKnk: an efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation. 2021.03.22.436484.
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Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., ... Zhang, R.
(2021).
Air pollution and children's health-a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter. Environmental Health and Preventive Medicine.
26(1), 72.
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Xie, Y., Ke, S., Chen, J., Ouyang, N., & Tian, Y.
(2020).
Epigenetic sensitization of pregnane X receptor-regulated gene expression by dimethyl sulfoxide. Toxicology Letters.
321, 131-137.
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Li, R. F., Liu, S. P., Yuan, Z. H., Yi, J. E., Tian, Y. N., Wu, J., & Wen, L. X.
(2020).
Effects of induced stress from the live LaSota Newcastle disease vaccination on the growth performance and immune function in broiler chickens. Poultry Science.
99(4), 1896-1905.
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Song, R., Zhai, Q., Sun, L. u., Huang, E., Zhang, Y. u., Zhu, Y., ... Lu, H.
(2019).
CRISPR/Cas9 genome editing technology in filamentous fungi: progress and perspective. Applied Microbiology and Biotechnology.
103(17), 6919-6932.
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Zhou, J., Li, H., Cai, Y., Ma, L., Mathews, D., Lu, B., ... Wu, C.
(2019).
Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH. Journal of Endocrinology.
243(3), 199-209.
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Yan, H., Yang, W., Zhou, F., Li, X., Pan, Q., Shen, Z., ... Guo, S.
(2019).
Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1. Diabetes.
68(2), 291-304.
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Wu, J., Zhou, Y. u., Yuan, Z., Yi, J., Chen, J., Wang, N., & Tian, Y.
(2019).
Autophagy and Apoptosis Interact to Modulate T-2 Toxin-Induced Toxicity in Liver Cells. Toxins.
11(1), 45-45.
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Wang, S., Wang, J., Yang, L., Guo, R., Huang, E., Yang, H., ... Lu, H.
(2019).
Swainsonine induces autophagy via PI3K/AKT/mTOR signaling pathway to injure the renal tubular epithelial cells. Biochimie.
165, 131-140.
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Yang, H., Wang, H., Liu, Y., Yang, L., Sun, L. u., Tian, Y., Zhao, B., & Lu, H.
(2019).
The PI3K/Akt/mTOR signaling pathway plays a role in regulating aconitine-induced autophagy in mouse liver. Research in Veterinary Science.
124, 317-320.
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Chen, J., Zhong, L., Wu, J., Ke, S., Morpurgo, B., Golovko, A., ... Tian, Y.
(2018).
A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals. Journal of Visualized Experiments.
2018(136),
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Zhu, L., Yi, X., Zhao, J., Yuan, Z., Wen, L., Pozniak, B., ... Yi, J.
(2018).
Betulinic acid attenuates dexamethasone-induced oxidative damage through the JNK-P38 MAPK signaling pathway in mice. Biomedicine and Pharmacotherapy.
103, 499-508.
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Chen, J., Ke, S., Zhong, L., Wu, J., Tseng, A., Morpurgo, B., ... Tian, Y.
(2018).
Long noncoding RNA MALAT1 regulates generation of reactive oxygen species and the insulin responses in male mice. Biochemical Pharmacology.
152, 94-103.
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Wu, J., Huang, W., Xiao, H., Xie, Y. i., Yuan, Z., Yi, J., ... Tian, Y.
(2018).
Procyanidins B2 reverses the T-2 toxin-induced mitochondrial apoptosis in TM3 Leydig cells. Journal of Functional Foods.
45, 118-128.
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Hasi, S., Yao, J., Yu, S., & Tian, Y.
(2018).
Diversity and distribution of CYP gene family in Bactrian camel. Functional and Integrative Genomics.
18(1), 23-29.
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He, L., Li, H., Huang, N., Zhou, X., Tian, J., Li, T., ... Yao, K.
(2017).
Alpha-ketoglutarate suppresses the NF-B-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway. Oncotarget.
8(61), 102974-102988.
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Wang, M., Maki, C. R., Deng, Y., Tian, Y., & Phillips, T. D.
(2017).
Development of High Capacity Enterosorbents for Aflatoxin B1 and Other Hazardous Chemicals. CHEMICAL RESEARCH IN TOXICOLOGY.
30(9), 1694-1701.
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Ma, N., Tian, Y., Wu, Y. i., & Ma, X. i.
(2017).
Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health. 18(8), 795-808.
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He, L., Zhou, X., Huang, N., Li, H., Li, T., Yao, K., ... Yin, Y.
(2017).
Functions of pregnane X receptor in self-detoxification. Amino Acids.
49(12), 1999-2007.
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Cui, H., Gu, X., Chen, J., Xie, Y., Ke, S., Wu, J., ... Tian, Y.
(2017).
Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[]-pyrene-induced DNA damage. Toxicology Letters.
275, 67-76.
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Yang, E., Wang, G., Yang, J., Zhou, B., Tian, Y., & Cai, J. J.
(2016).
Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action. Human Molecular Genetics.
25(22), 4911-4919.
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Yang, E., Wang, G., Yang, J., Zhou, B., Tian, Y., & Cai, J. J.
(2015).
Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action. 026393.
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Chen, J., Li, Y., Tian, Y., Huang, C., Li, D., Zhong, Q., & Ma, X. i.
(2015).
Interaction between Microbes and Host Intestinal Health: Modulation by Dietary Nutrients and Gut-Brain-Endocrine-Immune Axis. 16(7), 592-603.
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Ma, X. i., Chen, J., & Tian, Y.
(2015).
Pregnane X receptor as the "sensor and effector" in regulating epigenome. Journal of Cellular Physiology.
230(4), 752-757.
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Wu, J., Tu, D. i., Yuan, L., Yi, J., & Tian, Y.
(2015).
T-2 toxin regulates steroid hormone secretion of rat ovarian granulosa cells through cAMP-PKA pathway. Toxicology Letters.
232(3), 573-579.
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Tian, Y.
(2013).
Epigenetic regulation of pregnane X receptor activity. Drug Metabolism Reviews.
45(2), 166-172.
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Ouyang, N., Ke, S., Eagleton, N., Xie, Y., Chen, G., Laffins, B., ... Tian, Y.
(2010).
Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells. British Journal of Cancer.
102(12), 1753-1761.
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Ouyang, N., Storts, R., Tian, Y., Wigle, W., Villanueva, I., Mirhosseini, N., ... Tizard, I.
(2009).
Histopathology and the detection of avian bornavirus in the nervous system of birds diagnosed with proventricular dilatation disease. Avian Pathology.
38(5), 393-401.
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Liu, M., Takahashi, Y., Wada, T., He, J., Gao, J., Tian, Y., Li, S., & Xie, W.
(2009).
The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor. Molecular Pharmacology.
76(3), 604-611.
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Xie, Y., Ke, S., Ouyang, N., He, J., Xie, W., Bedford, M. T., & Tian, Y.
(2009).
Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. 284(14), 9199-9205.
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Tian, Y.
(2009).
Ah receptor and NF-kappaB interplay on the stage of epigenome. Biochemical Pharmacology.
77(4), 670-680.
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Wu, M., Liang, F., & Tian, Y.
(2009).
Bayesian modeling of ChIP-chip data using latent variables. BMC Bioinformatics.
10(1), 352.
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Fan, Y., Zhan, Y., Aukema, H. M., Davidson, L. A., Zhou, L., Callaway, E., ... Chapkin, R. S.
(2009).
Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice. Journal of Nutrition.
139(7), 1328-1332.
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Naspinski, C., Gu, X., Zhou, G., Mertens-Talcott, S. U., Donnelly, K. C., & Tian, Y.
(2008).
Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage. TOXICOLOGICAL SCIENCES.
104(1), 67-73.
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Chandra, D., Ayres, M., Gandhi, V., Bratton, S. B., Person, M. D., Tian, Y., Martin, A. G., & Fearnhead, H. O.
(2006).
Does ATP promote or protect cells from apoptosis?. Cancer Biology and Therapy.
5(7), 712.
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Gu, X., Ke, S., Liu, D., Sheng, T., Thomas, P. E., Rabson, A. B., ... Tian, Y.
(2006).
Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. 281(26), 17882-17889.
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Chandra, D., Bratton, S. B., Person, M. D., Tian, Y., Martin, A. G., Ayres, M., ... Tang, D. G.
(2006).
Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Cell.
125(7), 1333-1346.
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Xie, W., & Tian, Y.
(2006).
Xenobiotic receptor meets NF-kappaB, a collision in the small bowel. Cell Metabolism.
4(3), 177-178.
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Tian, Y., Ke, S., Chen, M., & Sheng, T.
(2003).
Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter. Journal of Biological Chemistry.
278(45), 44041-44048.
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Tian, Y., Rabson, A. B., & Gallo, M. A.
(2002).
Ah receptor and NF-kappaB interactions: mechanisms and physiological implications. CHEMICO-BIOLOGICAL INTERACTIONS.
141(1-2), 97-115.
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Ke, S., Rabson, A. B., Germino, J. F., Gallo, M. A., & Tian, Y.
(2001).
Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide. 276(43), 39638-39644.
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Tian, Y., Ke, S., Denison, M. S., Rabson, A. B., & Gallo, M. A.
(1999).
Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. Journal of Biological Chemistry.
274(1), 510-515.
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Tian, Y., Ke, S., Thomas, T., Meeker, R. J., & Gallo, M. A.
(1998).
Transcriptional suppression of estrogen receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The Journal of Steroid Biochemistry and Molecular Biology.
67(1), 17-24.
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Tian, Y., Ke, S., Thomas, T., Meeker, R. J., & Gallo, M. A.
(1998).
Regulation of estrogen receptor mRNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin as measured by competitive RT-PCR. 12(2), 71-77.
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Fang, X., Ni, N., Wang, X., Tian, Y., Ivanov, I., Rijnkels, M., ... Li, Q.
(2022).
EZH2 and Endometrial Cancer Development: Insights from a Mouse Model. 11(5), 909-909.
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chapter
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Tian, Y., Ouyang, N., & Thomas, P. E.
(2010).
Regulation of Xenobiotic Sensor PXR and AhR by NF-kappa B and Its Roles in Xenobiotic Detoxification and Inflammation-Associated Carcinogenesis. COMPREHENSIVE TOXICOLOGY, VOL 2: CELLULAR AND MOLECULAR TOXICOLOGY, 2ND EDITION.
(pp. 579-585).
Elsevier.
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Tian, Y., Ouyang, N., & Thomas, P. E.
(2010).
Regulation of Xenobiotic Sensor PXR and AhR by NF-kappa B and Its Roles in Xenobiotic Detoxification and Inflammation-Associated Carcinogenesis. COMPREHENSIVE TOXICOLOGY, VOL 2: CELLULAR AND MOLECULAR TOXICOLOGY, 2ND EDITION.
(pp. 579-585).
Elsevier.
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conference paper
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Sheng, T., Xie, W., Chen, M., Thomas, P. E., Gallo, M. A., Ke, S., & Tian, Y.
(2003).
A cell-based assay for screening inducers of cytochrome P450 3A4 and analyzing transcriptional regulation by pregane X receptor (PXR). TOXICOLOGICAL SCIENCES.
111-111.
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Chen, M., Ke, S., Sheng, T., & Tian, Y.
(2003).
Ah receptor-mediated transcriptional suppression of interleukin-6. TOXICOLOGICAL SCIENCES.
108-108.
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Tian, Y., Ke, S., Chen, M., Rabson, A. B., Gallo, M. A., & Sheng, T.
(2003).
Regulation of CYF1A1 transcription elongation by aft receptor through interaction with P-TEF B. TOXICOLOGICAL SCIENCES.
65-65.
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Sheng, T., Xie, W., Chen, M., Thomas, P. E., Gallo, M. A., Ke, S., & Tian, Y.
(2003).
A cell-based assay for screening inducers of cytochrome P450 3A4 and analyzing transcriptional regulation by pregane X receptor (PXR). TOXICOLOGICAL SCIENCES.
111-111.
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institutional repository document
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Osorio, D., Zhong, Y., Li, G., Xu, Q., Yang, Y., Hillhouse, A., ... Cai, J. J.
(2021).
scTenifoldKnk: An Efficient Virtual Knockout Tool for Gene Function Predictions via Single-Cell Gene Regulatory Network Perturbation
-
Osorio, D., Zhong, Y., Li, G., Xu, Q., Yang, Y., Hillhouse, A., ... Cai, J. J.
(2021).
scTenifoldKnk: An Efficient Virtual Knockout Tool for Gene Function Predictions via Single-Cell Gene Regulatory Network Perturbation
Research
Teaching
teaching activities
- BIMS101 Intro To Biomedical Sc Instructor
- VTPP491 Hnr-research Instructor
- VTPP676 Gen & Molecular Toxic Instructor
- VTPP685 Directed Studies Instructor
- VTPP691 Research Instructor
Background
education and training
- Ph.D. in Microbiology and Molecular Genetics, Rutgers University - (New Brunswick, New Jersey, United States) 1993
- M.Sc. in Plant Pathology, South China Agricultural University - (Guangzhou, China) 1985
- B.S. in Agronomy, South China Agricultural University - (Guangzhou, China) 1982
Contact
first name
- Yanan
has last name
- Tian
mailing address
-
Texas A&M University
Vet Med - Physiology & Pharmacology
4466 TAMU
College Station, TX 77843-4466
USA
Other
- tianyanan@tamu.edu