Functions of pregnane X receptor in self-detoxification. Academic Article uri icon


  • Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification such as metabolic syndrome, xenobiotic metabolism, inflammatory responses, glucose, cholesterol and lipid metabolism, and endocrine homeostasis. Notably, much experimental and clinical evidence show that PXR senses xenobiotics and triggers the detoxification response to prevent diseases such as diabetes, obesity, intestinal inflammatory diseases and liver fibrosis. In this review we summarize recent advances on remarkable metabolic and regulatory versatility of PXR, and we emphasizes its role and potential implication as an effective modulator of self-detoxification in animals and humans.

published proceedings

  • Amino Acids

author list (cited authors)

  • He, L., Zhou, X., Huang, N., Li, H., Li, T., Yao, K., ... Yin, Y.

citation count

  • 16

complete list of authors

  • He, Liuqin||Zhou, Xihong||Huang, Niu||Li, Huan||Li, Tiejun||Yao, Kang||Tian, Yanan||Hu, Chien-An Andy||Yin, Yulong

publication date

  • January 2017