Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. Academic Article uri icon


  • The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants causing toxic responses in human and wildlife. NF-kappaB is a pleiotropic transcription factor controlling many physiological functions adversely affected by PAHs, including immune suppression, thymus involution, hyperkeratosis, and carcinogenesis. Here, we show physical interaction and mutual functional repression between AhR and NF-kappaB. This mutual repression may provide an underlying mechanism for many hitherto poorly understood PAH-induced toxic responses, and may also provide a mechanistic explanation for alteration of xenobiotic metabolism by cytokines and compounds that regulate NF-kappaB.

published proceedings

  • J Biol Chem

altmetric score

  • 3

author list (cited authors)

  • Tian, Y., Ke, S., Denison, M. S., Rabson, A. B., & Gallo, M. A.

citation count

  • 323

complete list of authors

  • Tian, Y||Ke, S||Denison, MS||Rabson, AB||Gallo, MA

publication date

  • January 1999