Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. Academic Article

abstract

• The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants causing toxic responses in human and wildlife. NF-kappaB is a pleiotropic transcription factor controlling many physiological functions adversely affected by PAHs, including immune suppression, thymus involution, hyperkeratosis, and carcinogenesis. Here, we show physical interaction and mutual functional repression between AhR and NF-kappaB. This mutual repression may provide an underlying mechanism for many hitherto poorly understood PAH-induced toxic responses, and may also provide a mechanistic explanation for alteration of xenobiotic metabolism by cytokines and compounds that regulate NF-kappaB.

authors

• Tian, Yanan

published proceedings

• J Biol Chem

altmetric score

• 3

author list (cited authors)

• Tian, Y., Ke, S., Denison, M. S., Rabson, A. B., & Gallo, M. A.

citation count

• 323

complete list of authors

• Tian, Y||Ke, S||Denison, MS||Rabson, AB||Gallo, MA

publication date

• January 1999

publisher

• Elsevier  Publisher

published in

• Journal of Biological Chemistry  Journal

keywords

• Animals
• Base Sequence
• COS Cells
• Cytochrome P-450 CYP1A1
• Cytochrome P-450 Cyp1a2
• DNA Primers
• Gene Expression Regulation, Enzymologic
• Mice
• NF-kappa B
• Polychlorinated Dibenzodioxins
• Protein Binding
• Receptors, Aryl Hydrocarbon
• Tumor Cells, Cultured

Digital Object Identifier (DOI)

• 10.1074/jbc.274.1.510

start page

• 510

end page

• 515

volume

• 274

issue

• 1

URL

• http://dx.doi.org/10.1074/jbc.274.1.510