Xenobiotic receptor meets NF-κB, a collision in the small bowel Academic Article uri icon

abstract

  • It has long been appreciated that inflammation and infection reduce drug metabolism and that exposure to drug metabolism-inducing xenobiotics can impair immune function. A new study reveals the mutual repression between the xenobiotic nuclear receptor PXR/SXR and NF-kappaB signaling pathways, providing a molecular mechanism linking xenobiotic metabolism and inflammation (Zhou et al.,).

author list (cited authors)

  • Xie, W., & Tian, Y.

citation count

  • 57

publication date

  • September 2006