HR job title
- Professor
- Contact Info
- 1 979 458 0753
Heaps, Cristine Dr.
Positions
- Associate Professor and Associate Department Head, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
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Overview
Publications
selected publications
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academic article
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Sytha, S. P., Bray, J. F., & Heaps, C. L.
(2023).
Exercise induces superoxide and NOX4 contribution in endothelium-dependent dilation in coronary arterioles from a swine model of chronic myocardial ischemia. Microvascular Research.
150, 104590-104590.
-
Johnson, K. A., Jeffery, E., Bray, J. F., Murphy, M. M., & Heaps, C. L.
(2023).
Exercise training rescues impaired H2O2-mediated vasodilation in porcine collateral-dependent coronary arterioles through enhanced K+ channel activation. 324(5), H637-H653.
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Singh, R., Heaps, C. L., Muthuchamy, M., Deveau, M. A., Stewart, R. H., Laine, G. A., & Dongaonkar, R. M.
(2023).
Dichotomous effects of in vivo and in vitro ionizing radiation exposure on lymphatic function. American Journal of Physiology: Heart and Circulatory Physiology.
324(1), H155-H171.
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Ginn-Hedman, A., Self, T. S., Jessen, S. L., Heaps, C. L., Weeks, B. R., & Clubb, F. J.
(2022).
Diffusible contrast-enhanced micro-CT improves visualization of stented vessels. Cardiovascular Pathology.
60, 107428-107428.
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Sytha, S. P., Bray, J. F., Ramirez, C. R., & Heaps, C. L.
(2022).
Exercise Training Shifts Dependency from NADPH Oxidase 2 to NADPH Oxidase 4 in EndotheliumDependent Dilation in Coronary Arterioles Distal to Chronic Occlusion. The FASEB Journal.
36(S1),
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Yu, X., Nguyen, P., Burns, N. C., Heaps, C. L., Stallone, J. N., Sohrabji, F., & Han, G.
(2022).
Activation of G protein-coupled estrogen receptor fine-tunes age-related decreased vascular activities in the aortae of female and male rats. Steroids.
183, 108997-108997.
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Merkus, D., Muller-Delp, J., & Heaps, C. L.
(2021).
Coronary microvascular adaptations distal to epicardial artery stenosis. American Journal of Physiology: Heart and Circulatory Physiology.
320(6), H2351-H2370.
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Sytha, S., Ramirez, C., Bray, J., & Heaps, C.
(2021).
Exercise Training Increases the Contribution of NADPH Oxidase 4 to EndotheliumDependent Dilation in CollateralDependent Coronary Arterioles. The FASEB Journal.
35(S1),
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Johnson, K., Bray, J., & Heaps, C.
(2021).
Exercise Training Rescues Impaired H 2 O 2 Mediated Vasodilation in CollateralDependent Coronary Arterioles Through Enhanced K + Channel Activation. The FASEB Journal.
35(S1),
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Self, T. S., Ginn-Hedman, A., Newell-Fugate, A. E., Weeks, B. R., & Heaps, C. L.
(2021).
Iodine-based contrast staining improves micro-computed tomography of atherosclerotic coronary arteries. MethodsX.
8, 101297-101297.
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Self, T. S., Ginn-Hedman, A., Kaulfus, C. N., Newell-Fugate, A. E., Weeks, B. R., & Heaps, C. L.
(2020).
Iodine-enhanced micro-computed tomography of atherosclerotic plaque morphology complements conventional histology. 313, 43-49.
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Heaps, C. L., Bray, J. F., & Parker, J. L.
(2020).
Enhanced KCl-mediated contractility and Ca2+ sensitization in porcine collateral-dependent coronary arteries persist after exercise training. American Journal of Physiology: Heart and Circulatory Physiology.
319(4), H915-H926.
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Johnson, K., Ramirez, C., Bray, J., & Heaps, C.
(2020).
Exercise Training Restores K+ Channel Contributions to Hydrogen Peroxide-Mediated Dilation Independent of PKG Dimerization in Collateral-Dependent Coronary Arterioles. The FASEB Journal.
34(S1), 1-1.
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Orzabal, M. R., Lunde-Young, E. R., Ramirez, J. I., Howe, S., Naik, V. D., Lee, J., ... Ramadoss, J.
(2019).
Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits. 207, 70-82.
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Yu, X., Stallone, J. N., Heaps, C. L., & Han, G.
(2018).
The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries. PLoS One.
13(1), e0191418-e0191418.
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Yu, X., Zhang, Q., Zhao, Y., Schwarz, B. J., Stallone, J. N., Heaps, C. L., & Han, G.
(2017).
Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA. PLoS One.
12(3), e0173085-e0173085.
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Dongaonkar, R. M., Nguyen, T. L., Quick, C. M., Heaps, C. L., Hardy, J., Laine, G. A., Wilson, E., & Stewart, R. H.
(2015).
Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
308(5), R391-R399.
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Zheng, X., Heaps, C. L., & Fisher, S. A.
(2015).
Myosin phosphatase isoforms and related transcripts in the pig coronary circulation and effects of exercise and chronic occlusion. Microvascular Research.
98, 166-171.
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Robles, J. C., & Heaps, C. L.
(2015).
Adaptations of the endothelin system after exercise training in a porcine model of ischemic heart disease. Microcirculation.
22(1), 68-78.
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Heaps, C. L., Robles, J. C., Sarin, V., Mattox, M. L., & Parker, J. L.
(2014).
Exercise training-induced adaptations in mediators of sustained endothelium-dependent coronary artery relaxation in a porcine model of ischemic heart disease. Microcirculation.
21(5), 388-400.
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Meininger, C., Stees, M., Kelly, K., Heaps, C., Wu, G., & Labhasetwar, V.
(2014).
Orallydelivered, tetrahydrobiopterincontaining nanoparticles targeting gastrointestinal lymphatics modulate nitric oxide synthesis by aortic endothelial cells (666.4). The FASEB Journal.
28(S1),
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Deer, R. R., & Heaps, C. L.
(2013).
Exercise training enhances multiple mechanisms of relaxation in coronary arteries from ischemic hearts. American Journal of Physiology: Heart and Circulatory Physiology.
305(9), H1321-H1331.
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Li, F., Yu, X., Szynkarski, C. K., Meng, C., Zhou, B., Barhoumi, R., ... Han, G.
(2013).
Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation. PLoS One.
8(6), e64771-e64771.
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Xie, W., Parker, J. L., & Heaps, C. L.
(2013).
Exercise training-enhanced, endothelium-dependent dilation mediated by altered regulation of BK(Ca) channels in collateral-dependent porcine coronary arterioles. Microcirculation.
20(2), 170-182.
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Li, F., Yu, X., Szynkarski, C. K., Meng, C., Zhou, B., Barhoumi, R., ... Han, G.
(2013).
Correction: Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation. PLoS One.
8(7), 10.1371/annotation/ce509358-9f5c-4a8c-9b0d-80.
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Xie, W., Parker, J. L., & Heaps, C. L.
(2012).
Effect of exercise training on nitric oxide and superoxide/HO signaling pathways in collateral-dependent porcine coronary arterioles. Journal of Applied Physiology.
112(9), 1546-1555.
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Robles, J. C., & Heaps, C.
(2012).
CaM Kinase II and Ca2+ sensitization mediate enhanced KCl constriction in collateraldependent coronary arteries of both sedentary and exercisetrained pigs. The FASEB Journal.
26(S1), 1055.15-1055.15.
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Sarin, V., Muthuchamy, M., & Heaps, C. L.
(2011).
Ca sensitization of cardiac myofilament proteins contributes to exercise training-enhanced myocardial function in a porcine model of chronic occlusion. American Journal of Physiology: Heart and Circulatory Physiology.
301(4), H1579-H1587.
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Heaps, C. L., & Parker, J. L.
(2011).
Effects of exercise training on coronary collateralization and control of collateral resistance. Journal of Applied Physiology.
111(2), 587-598.
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Robles, J. C., Sturek, M., Parker, J. L., & Heaps, C. L.
(2011).
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries. American Journal of Physiology: Heart and Circulatory Physiology.
300(4), H1201-H1209.
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Wu, X., Chakraborty, S., Heaps, C. L., Davis, M. J., Meininger, G. A., & Muthuchamy, M.
(2011).
Fibronectin increases the force production of mouse papillary muscles via 51 integrin. Journal of Molecular and Cellular Cardiology.
50(1), 203-213.
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Zhou, M., Widmer, R. J., Xie, W., Jimmy Widmer, A., Miller, M. W., Schroeder, F., Parker, J. L., & Heaps, C. L.
(2010).
Effects of exercise training on cellular mechanisms of endothelial nitric oxide synthase regulation in coronary arteries after chronic occlusion. American Journal of Physiology: Heart and Circulatory Physiology.
298(6), H1857-H1869.
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Fogarty, J. A., Delp, M. D., Muller-Delp, J. M., Laine, G. A., Parker, J. L., & Heaps, C. L.
(2009).
Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs. Journal of Vascular Research.
46(2), 152-161.
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Heaps, C. L., Jeffery, E. C., Laine, G. A., Price, E. M., & Bowles, D. K.
(2008).
Effects of exercise training and hypercholesterolemia on adenosine activation of voltage-dependent K+ channels in coronary arterioles. Journal of Applied Physiology.
105(6), 1761-1771.
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Forough, R., Miller, M. W., Mattox, M., Dunlap, W., Ambrus, A., Barhoumi, R., Heaps, C. L., & Parker, J. L.
(2008).
Enhanced myocardial vascularity and contractility by novel FGF-1 transgene in a porcine model of chronic coronary occlusion. Journal of Tehran University Heart Center.
3(4), 197-204.
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Wu, G., Collins, J. K., Perkins-Veazie, P., Siddiq, M., Dolan, K. D., Kelly, K. A., Heaps, C. L., & Meininger, C. J.
(2007).
Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats. The Journal of Nutrition.
137(12), 2680-2685.
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Steelman, S., & Heaps, C.
(2007).
Protein kinase C contributes to enhanced calcium sensitivity in coronary arteries from hypercholesterolemic swine. The FASEB Journal.
21(6), a1227-a1227.
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Bruce, S. M., & Heaps, C.
(2006).
Enhanced protein kinase C contribution to agonistmediated contraction in coronary arteries from hypercholesterolemic swine. The FASEB Journal.
20(5), a1399-a1399.
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Heaps, C. L., Mattox, M. L., Kelly, K. A., Meininger, C. J., & Parker, J. L.
(2006).
Exercise training increases basal tone in arterioles distal to chronic coronary occlusion. American Journal of Physiology: Heart and Circulatory Physiology.
290(3), H1128-H1135.
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Korzick, D. H., Muller-Delp, J. M., Dougherty, P., Heaps, C. L., Bowles, D. K., & Krick, K. K.
(2005).
Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C. Cardiovascular Research.
66(2), 384-392.
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Heaps, C. L., Tharp, D. L., & Bowles, D. K.
(2005).
Hypercholesterolemia abolishes voltage-dependent K+ channel contribution to adenosine-mediated relaxation in porcine coronary arterioles. American Journal of Physiology: Heart and Circulatory Physiology.
288(2), H568-H576.
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Bowles, D. K., Maddali, K. K., Ganjam, V. K., Rubin, L. J., Tharp, D. L., Turk, J. R., & Heaps, C. L.
(2004).
Endogenous testosterone increases L-type Ca2+ channel expression in porcine coronary smooth muscle. American Journal of Physiology: Heart and Circulatory Physiology.
287(5), H2091-H2098.
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Heaps, C. L., Parker, J. L., Sturek, M., & Bowles, D. K.
(2004).
Altered calcium sensitivity contributes to enhanced contractility of collateral-dependent coronary arteries. Journal of Applied Physiology.
97(1), 310-316.
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Bowles, D. K., Heaps, C. L., Turk, J. R., Maddali, K. K., & Price, E. M.
(2004).
Hypercholesterolemia inhibits L-type calcium current in coronary macro-, not microcirculation. Journal of Applied Physiology.
96(6), 2240-2248.
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Heaps, C. L., & Bowles, D. K.
(2002).
Nonuniform changes in arteriolar myogenic tone within skeletal muscle following hindlimb unweighting. Journal of Applied Physiology.
92(3), 1145-1151.
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Heaps, C. L., & Bowles, D. K.
(2002).
Gender-specific K(+)-channel contribution to adenosine-induced relaxation in coronary arterioles. Journal of Applied Physiology.
92(2), 550-558.
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Jones, J. J., Dietz, N. J., Heaps, C. L., Parker, J. L., & Sturek, M.
(2001).
Calcium buffering in coronary smooth muscle after chronic occlusion and exercise training. Cardiovascular Research.
51(2), 359-367.
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Heaps, C. L., Sturek, M., Price, E. M., Laughlin, M. H., & Parker, J. L.
(2001).
Sarcoplasmic reticulum Ca(2+) uptake is impaired in coronary smooth muscle distal to coronary occlusion. 281(1), H223-H231.
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Heaps, C. L., Sturek, M., Price, E. M., Laughlin, M. H., & Parker, J. L.
(2001).
Sarcoplasmic reticulum Ca2+ uptake is impaired in coronary smooth muscle distal to coronary occlusion. American Journal of Physiology: Heart and Circulatory Physiology.
281(1), H223-H231.
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Heaps, C. L., Bowles, D. K., Sturek, M., Laughlin, M. H., & Parker, J. L.
(2000).
Enhanced L-type Ca2+ channel current density in coronary smooth muscle of exercise-trained pigs is compensated to limit myoplasmic free Ca2+ accumulation. The Journal of Physiology.
528(Pt 3), 435-445.
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Heaps, C. L., Sturek, M., Rapps, J. A., Laughlin, M. H., & Parker, J. L.
(2000).
Exercise training restores adenosine-induced relaxation in coronary arteries distal to chronic occlusion. 278(6), H1984-H1992.
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Heaps, C. L., Bowles, D. K., Sturek, M., Laughlin, M. H., & Parker, J. L.
(2000).
Enhanced L-type Ca2+ channel current density in coronary smooth muscle of exercise-trained pigs is compensated to limit myoplasmic free Ca2+ accumulation. The Journal of Physiology.
528(3), 435-445.
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Heaps, C. L., Sturek, M., Rapps, J. A., Laughlin, M. H., & Parker, J. L.
(2000).
Exercise training restores adenosine-induced relaxation in coronary arteries distal to chronic occlusion. American Journal of Physiology: Heart and Circulatory Physiology.
278(6), H1984-H1992.
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Heaps, C. L., Rapps, J. A., Zhong, Q., Sturek, M., Laughlin, M. H., & Parker, J. L.
(1997).
Effects of exercise training on smooth muscle relaxation and myoplasmic free Ca 2+ (Ca m) responses of coronary arteries distal to chronic occlusion. The FASEB Journal.
11(3),
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Heaps, C. L., Fischer, M. D., & Hill, R. C.
(1997).
Female acceleration tolerance: effects of menstrual state and physical condition. Aviation, Space, and Environmental Medicine.
68(6), 525-530.
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Webb, J. T., Fischer, M. D., Heaps, C. L., & Pilmanis, A. A.
(1996).
Exercise-enhanced preoxygenation increases protection from decompression sickness. Aviation, Space, and Environmental Medicine.
67(7), 618-624.
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Heaps, C. L., & Constable, S. H.
(1995).
Physiological responses of rhesus monkeys to exercise at varied temperatures. Aviation, Space, and Environmental Medicine.
66(2), 137-142.
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Heaps, C. L., Gonzlez-Alonso, J., & Coyle, E. F.
(1994).
Hypohydration causes cardiovascular drift without reducing blood volume. International Journal of Sports Medicine.
15(2), 74-79.
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Heaps, C. L., & Constable, S. H.
(1993).
The Metabolic and Thermoregulatory Responses of Rhesus Monkeys to Combined Exercise and Environmental Heat Load
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Gonzlez-Alonso, J., Heaps, C. L., & Coyle, E. F.
(1992).
Rehydration after exercise with common beverages and water. International Journal of Sports Medicine.
13(5), 399-406.
-
Sytha, S. P., Bray, J. F., & Heaps, C. L.
(2023).
Exercise induces superoxide and NOX4 contribution in endothelium-dependent dilation in coronary arterioles from a swine model of chronic myocardial ischemia. Microvascular Research.
150, 104590-104590.
-
chapter
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Sytha, S. P., Self, T. S., & Heaps, C. L.
(2022).
K+ channels in the coronary microvasculature of the ischemic heart. Current Topics in Membranes.
ION TRANSPORT AND MEMBRANE INTERACTIONS IN VASCULAR HEALTH AND DISEASE.
(pp. 141-166).
Elsevier.
-
Sytha, S. P., Self, T. S., & Heaps, C. L.
(2022).
K+ channels in the coronary microvasculature of the ischemic heart. Current Topics in Membranes.
ION TRANSPORT AND MEMBRANE INTERACTIONS IN VASCULAR HEALTH AND DISEASE.
(pp. 141-166).
Elsevier.
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conference paper
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Harlow, R. C., Singh, R., Bagher, P., Heaps, C. L., Stewart, R. H., & Dongaonkar, R. M.
(2022).
Prolonged Exposure to Intestinal Edemagenic Stress Decreases Mesenteric Lymphatic Contractility. The FASEB Journal.
-
Heaps, C. L., Bray, J. F., McIntosh, A. L., & Schroeder, F.
(2019).
Endothelial nitric oxide synthase protein distribution and nitric oxide production in endothelial cells along the coronary vascular tree. Microvascular Research.
34-40.
-
Dongaonkar, R. M., Nguyen, T. L., Quick, C. M., Laine, G. A., Wilson, E., Heaps, C., Hardy, J., & Stewart, R. H.
(2013).
Post-nodal lymphatic vessels adapt to sustained high flow conditions by becoming weaker pumps. The FASEB Journal.
902.5-902.5.
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Muthuchamy, M., Chakraborty, S., Wu, X., Sarin, V., & Heaps, C. L.
(2012).
Exercise-Induced Changes in Mechanotransduction Improve Myocardial Function in a Porcine Model of Chronic Occlusion. Circulation.
-
Robles, J. C., Mattox, M. L., Parker, J. L., & Heaps, C. L.
(2010).
Exercise Training Enhances PKC-Mediated Ca2+ Sensitization in Collateral-Dependent Porcine Coronary Arteries. Arteriosclerosis, Thrombosis and Vascular Biology.
E304-E304.
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Li, F., Wang, G., Zhou, B., White, R., Heaps, C., Stallone, J., & Han, G.
Activation of G-protein-coupled estrogen receptor (GPER) inhibits coronary artery smooth muscle cell proliferation. The FASEB Journal.
663.9-663.9.
-
Harlow, R. C., Singh, R., Bagher, P., Heaps, C. L., Stewart, R. H., & Dongaonkar, R. M.
(2022).
Prolonged Exposure to Intestinal Edemagenic Stress Decreases Mesenteric Lymphatic Contractility. The FASEB Journal.
Research
principal investigator on
- Exercise Training-Enhanced Reactive Oxygen Species as Protective Mechanisms in the Coronary Microcirculation awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2022
- Exercise-induced reactive oxidants as microvascular protective mechanisms awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2015 - 2017
Teaching
teaching activities
- BIMS491 Research Instructor
- VTPP285 Directed Studies Instructor
- VTPP485 Directed Studies Instructor
- VTPP485 Hnr-directed Studies Instructor
- VTPP491 Hnr-research Instructor
- VTPP610 Physiology I Instructor
- VTPP655 Vascular Physiology Instructor
- VTPP685 Directed Studies Instructor
- VTPP691 Research Instructor
Works By Students
chaired theses and dissertations
-
Boone, Stephanie Rose (2017-12). Commonly Used Intra-Articular Medications Affect Bone Marrow-Derived Mesenchymal Stem Cell Growth and Viability.
Background
education and training
- Ph.D. in Physiology, University of Missouri - (Columbia, Missouri, United States) 1999
awards and honors
Contact
first name
- Cristine
has last name
- Heaps
mailing address
-
Texas A&M University
Vet Med - Physiology & Pharmacology
4466 TAMU
College Station, TX 77843-4466
USA
Other
- cheaps@tamu.edu