HR job title
- Professor
- Contact Info
- 12547211001
Glaser, Shannon Professor
Positions
- Professor, Medical Physiology, College of Medicine
The long-term goal of my research program is to understand how activated (proliferating) cholangiocytes participate in the progression of cholestatic liver diseases and eventual development of cholangiocarcinoma. My research is focused on elucidating the factors (such as, mechanical stress) and intracellular signaling mechanisms that regulate cholangiocyte proliferation and biliary fibrosis during extrahepatic cholestasis.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Kyritsi, K., Wu, N., Zhou, T., Carpino, G., Baiocchi, L., Kennedy, L., ... Alpini, G.
(2023).
Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity. 13(1), 5.
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Ceci, L., Chen, L., Baiocchi, L., Wu, N., Kennedy, L., Carpino, G., ... Glaser, S.
(2022).
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model. 14(4), 877-904.
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Kennedy, L., Francis, H., Invernizzi, P., Venter, J., Wu, N., Carbone, M., ... Alpini, G.
(2019).
Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis. 33(9), 10269-10279.
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Zhou, T., & Glaser, S. S.
(2019).
Pleiotropic effects of CD5L in hepatic inflammation and fibrosis. EBioMedicine.
44, 22-23.
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McDaniel, K., Wu, N., Zhou, T., Huang, L. i., Sato, K., Venter, J., ... Meng, F.
(2019).
Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA. 69(6), 2562-2578.
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Wan, Y., Ceci, L., Wu, N., Zhou, T., Chen, L., Venter, J., ... Glaser, S.
(2019).
Knockout of -calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes. Laboratory Investigation.
99(6), 764-776.
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Chen, L., Zhou, T., Wu, N., O'Brien, A., Venter, J., Ceci, L., ... Glaser, S.
(2019).
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis. BBA: Molecular Basis of Disease.
1865(6), 1525-1539.
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Sato, K., Marzioni, M., Meng, F., Francis, H., Glaser, S., & Alpini, G.
(2019).
Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances. 69(1), 420-430.
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Raggi, C., Fiaccadori, K., Pastore, M., Correnti, M., Piombanti, B., Forti, E., ... Invernizzi, P.
(2019).
Antitumor Activity of a Novel Fibroblast Growth Factor Receptor Inhibitor for Intrahepatic Cholangiocarcinoma. American Journal of Pathology.
189(10), 2090-2101.
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Baiocchi, L., Zhou, T., Liangpunsakul, S., Lenci, I., Santopaolo, F., Meng, F., ... Alpini, G.
(2019).
Dual Role of Bile Acids on the Biliary Epithelium: Friend or Foe?. International Journal of Molecular Sciences.
20(8), 1869-1869.
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Navas, M., Glaser, S., Dhruv, H., Celinski, S., Alpini, G., & Meng, F.
(2019).
Hepatitis C Virus Infection and Cholangiocarcinoma: An Insight into Epidemiologic Evidences and Hypothetical Mechanisms of Oncogenesis. American Journal of Pathology.
189(6), 1122-1132.
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Sato, K., Kennedy, L., Liangpunsakul, S., Kusumanchi, P., Yang, Z., Meng, F., ... Alpini, G.
(2019).
Intercellular Communication between Hepatic Cells in Liver Diseases. International Journal of Molecular Sciences.
20(9), 2180-2180.
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Sato, K., Glaser, S., Kennedy, L., Liangpunsakul, S., Meng, F., Francis, H., & Alpini, G.
(2019).
Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets. Expert Opinion on Therapeutic Targets.
23(6), 461-472.
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Pei, Y. a., Li, H., Cai, Y., Zhou, J., Luo, X., Ma, L., ... Wu, C.
(2018).
Regulation of adipose tissue inflammation by adenosine 2A receptor in obese mice. Journal of Endocrinology.
239(3), 365-376.
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Wu, N., McDaniel, K., Zhou, T., Ramos-Lorenzo, S., Wu, C., Huang, L. i., ... Meng, F.
(2018).
Knockout of microRNA-21 attenuates alcoholic hepatitis through the VHL/NF-B signaling pathway in hepatic stellate cells. American Journal of Physiology - Gastrointestinal and Liver Physiology.
315(3), G385-G398.
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Ehrlich, L., O'Brien, A., Hall, C., White, T., Chen, L., Wu, N., ... Glaser, S.
(2018).
7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice. Gene Expression: International Journal of Molecular and Cellular Science.
18(3), 197-207.
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Cai, Y., Li, H., Liu, M., Pei, Y. a., Zheng, J., Zhou, J., ... Wu, C.
(2018).
Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity. HEPATOLOGY.
68(1), 48-61.
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Sato, K., Meng, F., Venter, J., Giang, T., Glaser, S., & Alpini, G.
(2018).
Author Correction: The role of the secretin/secretin receptor axis in inflammatory cholangiocyte communication via extracellular vesicles. Scientific Reports.
8(1), 11238.
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Ehrlich, L., Scrushy, M., Meng, F., Lairmore, T. C., Alpini, G., & Glaser, S.
(2018).
Biliary epithelium: A neuroendocrine compartment in cholestatic liver disease. Clinics and Research in Hepatology and Gastroenterology.
42(4), 296-305.
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Lewis, P. L., Su, J., Yan, M., Meng, F., Glaser, S. S., Alpini, G. D., ... Shah, R. N.
(2018).
Complex bile duct network formation within liver decellularized extracellular matrix hydrogels. Scientific Reports.
8(1), 12220.
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Luo, X., Li, H., Ma, L., Zhou, J., Guo, X., Woo, S., ... Wu, C.
(2018).
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice. Gastroenterology.
155(6), 1971-1984.e4.
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Zhou, T., Wu, N., Meng, F., Venter, J., Giang, T. K., Francis, H., ... Alpini, G.
(2018).
Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2-/- mice by diminishing senescence of cholangiocytes. Laboratory Investigation.
98(11), 1449-1464.
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Sato, K., Meng, F., Giang, T., Glaser, S., & Alpini, G.
(2018).
Mechanisms of cholangiocyte responses to injury. BBA: Molecular Basis of Disease.
1864(4 Pt B), 1262-1269.
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Ehrlich, L., & Glaser, S. S.
(2018).
Novel -catenin/farnesoid X receptor interaction regulates hepatic bile acid metabolism during cholestasis. HEPATOLOGY.
67(3), 829-832.
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Wu, N., Meng, F., Zhou, T., Venter, J., Giang, T. K., Kyritsi, K., ... Franchitto, A.
(2018).
The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-1-Mediated Biliary Senescence. American Journal of Pathology.
188(10), 2264-2280.
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Scrushy, M., O'Brien, A., & Glaser, S.
(2018).
Recent advances in understanding bile duct remodeling and fibrosis. F1000Research.
7, f1000 faculty rev-1165-1165.
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McMillin, M., DeMorrow, S., Glaser, S., Venter, J., Kyritsi, K., Zhou, T., ... Alpini, G.
(2017).
Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. American Journal of Physiology - Gastrointestinal and Liver Physiology.
313(5), G410-G418.
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Wu, N., Meng, F., Zhou, T., Han, Y., Kennedy, L., Venter, J., ... Alpini, G.
(2017).
Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation. The FASEB Journal.
31(10), 4305-4324.
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Ehrlich, L., Hall, C., Meng, F., Lairmore, T., Alpini, G., & Glaser, S.
(2017).
A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology. Gene Expression: International Journal of Molecular and Cellular Science.
17(3), 251-263.
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McDaniel, K., Huang, L. i., Sato, K., Wu, N., Annable, T., Zhou, T., ... Meng, F.
(2017).
The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. 292(27), 11336-11347.
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Hall, C., Sato, K., Wu, N., Zhou, T., Kyritsi, K., Meng, F., Glaser, S., & Alpini, G.
(2017).
Regulators of Cholangiocyte Proliferation. 17(2), 155-171.
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Raggi, C., Correnti, M., Sica, A., Andersen, J. B., Cardinale, V., Alvaro, D., ... Invernizzi, P.
(2017).
Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages. Journal of Hepatology.
66(1), 102-115.
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Raggi, C., Gammella, E., Correnti, M., Buratti, P., Forti, E., Andersen, J. B., ... Recalcati, S.
(2017).
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells. Scientific Reports.
7(1), 17667.
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McDaniel, K., Meng, F., Wu, N., Sato, K., Venter, J., Bernuzzi, F., ... Alpini, G.
(2017).
Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice. HEPATOLOGY.
65(2), 544-559.
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Hall, C., Ehrlich, L., Meng, F., Invernizzi, P., Bernuzzi, F., Lairmore, T. C., Alpini, G., & Glaser, S.
(2017).
Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2-/- mice. Journal of Surgical Research.
217, 160-169.
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Hall, C., Ehrlich, L., Venter, J., O'Brien, A., White, T., Zhou, T., ... Glaser, S.
(2017).
Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Letters.
386, 179-188.
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Kyritsi, K., Meng, F., Zhou, T., Wu, N., Venter, J., Francis, H., ... Glaser, S.
(2017).
Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b. American Journal of Pathology.
187(7), 1551-1565.
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Martnez, A. K., Jensen, K., Hall, C., O'Brien, A., Ehrlich, L., White, T., ... Glaser, S. S.
(2017).
Nicotine Promotes Cholangiocarcinoma Growth in Xenograft Mice. American Journal of Pathology.
187(5), 1093-1105.
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Wan, Y., McDaniel, K., Wu, N., Ramos-Lorenzo, S., Glaser, T., Venter, J., ... Meng, F.
(2017).
Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury. American Journal of Pathology.
187(12), 2788-2798.
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Wan, Y., Meng, F., Wu, N., Zhou, T., Venter, J., Francis, H., ... Alpini, G.
(2017).
Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells. HEPATOLOGY.
66(2), 528-541.
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Wu, N., Nguyen, Q., Wan, Y., Zhou, T., Venter, J., Frampton, G. A., ... Bai, H.
(2017).
The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals. Laboratory Investigation.
97(7), 843-853.
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Sato, K., Meng, F., Venter, J., Giang, T., Glaser, S., & Alpini, G.
(2017).
The role of the secretin/secretin receptor axis in inflammatory cholangiocyte communication via extracellular vesicles. Scientific Reports.
7(1), 11183.
-
Ehrlich, L., Hall, C., Venter, J., Dostal, D., Bernuzzi, F., Invernizzi, P., ... Glaser, S.
(2017).
miR-24 Inhibition Increases Menin Expression and Decreases Cholangiocarcinoma Proliferation. American Journal of Pathology.
187(3), 570-580.
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Krishnamurthy, K., Glaser, S., Alpini, G. D., Cardounel, A. J., Liu, Z., & Ilangovan, G.
(2016).
Heat shock factor-1 knockout enhances cholesterol 7-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis. Cardiovascular Research.
111(1), 74-83.
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McDaniel, K., Hall, C., Sato, K., Lairmore, T., Marzioni, M., Glaser, S., Meng, F., & Alpini, G.
(2016).
Lin28 and let-7: Roles and regulation in liver diseases. American Journal of Physiology - Gastrointestinal and Liver Physiology.
310(10), G757-G765.
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McDaniel, K., Hall, C., Sato, K., Lairmore, T., Marzioni, M., Glaser, S., Meng, F., & Alpini, G.
(2016).
Lin28 and let-7: roles and regulation in liver diseases. American Journal of Physiology - Gastrointestinal and Liver Physiology.
310(10), G757-G765.
-
Wu, N., Meng, F., Venter, J., Kyritsi, K., Francis, H. L., Hall, C., ... Alpini, G.
(2016).
Tu1694 Regulation of Cellular Senescence Associated Liver Fibrosis By Melatonin in Cholestatic Liver Injury. Gastroenterology.
150(4), s1165-S1165.
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Nizamutdinov, D., Feng, H., Gerilechaogetu, F., Dostal, J. A., Foster, D. M., Glaser, S. S., & Dostal, D. E.
(2016).
Isolated neonatal rat papillary muscles: a new model to translate neonatal rat myocyte signaling into contractile mechanics. Physiological Reports.
4(3), e12694-e12694.
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Wan, Y., Garner, J., Wu, N., Phillip, L., Han, Y., McDaniel, K., ... Meng, F.
(2016).
Role of stem cells during diabetic liver injury. Journal of Cellular and Molecular Medicine.
20(2), 195-203.
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Zhou, T., Francis, H. L., Wan, Y., Venter, J., Wu, N., McDaniel, K., ... Meng, F.
(2016).
287 Senescence of Activated Hepatic Stellate Cells Limits Liver Fibrosis During Alcoholic Liver Injury. Gastroenterology.
150(4), s1025-S1025.
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Wan, Y., Francis, H. L., Wu, N., McDaniel, K., Zhou, T., Venter, J., ... Meng, F.
(2016).
653 microRNA-34a Regulates Alcoholic Hepatitis Through SIRT1/NF-kappa;B Pathway. Gastroenterology.
150(4), s1043-S1043.
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McDaniel, K., Wan, Y., Wu, N., Venter, J., Francis, H. L., Zhou, T., ... Meng, F.
(2016).
745 Inhibition of Hepatic Stellate Cell Activation by Stem Cell Derived Extracellular Vesicles and microRNAs During Cholestatic Liver Injury. Gastroenterology.
150(4), s1044-s1045.
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Wu, N., Meng, F., Venter, J., Francis, H. L., Standeford, H., DeMorrow, S., ... Glaser, S.
(2016).
750 Melatonin Therapy Reduces Biliary Proliferation and Hepatic Fibrosis in the Mdr2/ Mouse Model of Primary Sclerosing Cholangitis (PSC) By Decreased Expression of miR-200b and Angiogenic Factors. Gastroenterology.
150(4), s1046-S1046.
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Sato, K., Meng, F., Glaser, S., & Alpini, G.
(2016).
Corrigendum to "Exosomes in liver pathology". Journal of Hepatology.
65(3), 655-655.
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Sato, K., Meng, F., Glaser, S., & Alpini, G.
(2016).
Exosomes in liver pathology. Journal of Hepatology.
65(1), 213-221.
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Kennedy, L. L., Meng, F., Venter, J. K., Zhou, T., Karstens, W. A., Hargrove, L. A., ... Alpini, G.
(2016).
Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice. Laboratory Investigation.
96(12), 1256-1267.
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Sato, K., Hall, C., Glaser, S., Francis, H., Meng, F., & Alpini, G.
(2016).
Pathogenesis of Kupffer Cells in Cholestatic Liver Injury. American Journal of Pathology.
186(9), 2238-2247.
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Wu, N., Meng, F., Invernizzi, P., Bernuzzi, F., Venter, J., Standeford, H., ... Alpini, G.
(2016).
The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-1 biliary secretion in mice. HEPATOLOGY.
64(3), 865-879.
-
McMillin, M., DeMorrow, S., Venter, J., Frampton, G., Bai, H., Glaser, S., & Alpini, G.
(2016).
Tu1613 Cranial Infusion of Melatonin in a Rat Model of Extrahepatic Cholestasis Reduces Biliary Proliferation and Liver Fibrosis. Gastroenterology.
150(4), s1149-S1149.
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Ehrlich, L., Hall, C., Venter, J., Standeford, H., Meng, F., Lairmore, T. C., Alpini, G., & Glaser, S.
(2016).
Tu1616 miR-125b Negatively Regulates Menin Expression and Protects from Liver Fibrosis. Gastroenterology.
150(4), s1150-S1150.
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McDaniel, K., Venter, J., Wu, N., Wan, Y., Francis, H. L., Zhou, T., ... Meng, F.
(2016).
Tu1618 Treatment of Biliary Injury With Small Cholangiocyte Therapy Decreases Stellate Cell Activation via Mediation of Cellular Senescence. Gastroenterology.
150(4), s1150-S1150.
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Wan, Y., Meng, F., McDaniel, K., Wu, N., Venter, J., Francis, H. L., ... Alpini, G.
(2016).
Tu1619 Blockade of Substance P Receptor attenuates Cellular Senescence and Liver Fibrosis in the Mdr2/ Mouse Model of Primary Sclerosing Cholangitis. Gastroenterology.
150(4), s1150-s1151.
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Navas, M. C., Wu, N., Venter, J., Meng, F., Onori, P., Gaudio, E., Glaser, S., & Alpini, G.
(2016).
Tu1698 Modulation of Epithelial Mesenchymal Transition by miRNA125b in Cholestatic Bile Duct Ligated (BDL) Mice. Gastroenterology.
150(4), s1166-S1166.
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Mancinelli, R., Franchitto, A., Glaser, S., Vetuschi, A., Venter, J., Sferra, R., ... Gaudio, E.
(2016).
Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease. Laboratory Investigation.
96(11), 1147-1155.
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Han, Y., Meng, F., Venter, J., Wu, N., Wan, Y., Standeford, H., ... Alpini, G.
(2016).
miR-34a-dependent overexpression of Per1 decreases cholangiocarcinoma growth. Journal of Hepatology.
64(6), 1295-1304.
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Feng, H., Gerilechaogetu, F., Golden, H. B., Nizamutdinov, D., Foster, D. M., Glaser, S. S., & Dostal, D. E.
(2016).
p38 MAPK inhibits stretch-induced JNK activation in cardiac myocytes through MKP-1. International Journal of Cardiology.
203, 145-155.
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Mancinelli, R., Glaser, S., Francis, H., Carpino, G., Franchitto, A., Vetuschi, A., ... Gaudio, E.
(2015).
Ischemia reperfusion of the hepatic artery induces the functional damage of large bile ducts by changes in the expression of angiogenic factors. American Journal of Physiology - Gastrointestinal and Liver Physiology.
309(11), G865-G873.
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Glaser, S., Han, Y., Venter, J., Martinez, A., O'Brien, A., Avila, S., ... Alpini, G.
(2015).
459 Inhibition of the Secretin/Secretin Receptor Axis Attenuates Biliary Fibrosis During Cholestasis. Gastroenterology.
148(4), s-980.
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Afroze, S. H., Munshi, M. K., Martnez, A. K., Uddin, M., Gergely, M., Szynkarski, C., ... Glaser, S.
(2015).
Activation of the renin-angiotensin system stimulates biliary hyperplasia during cholestasis induced by extrahepatic bile duct ligation. American Journal of Physiology - Gastrointestinal and Liver Physiology.
308(8), G691-G701.
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Dostal, D., Glaser, S., & Baudino, T. A.
(2015).
Cardiac fibroblast physiology and pathology. 5(2), 887-909.
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Wan, Y., Han, Y., McDaniel, K., Annable, T., Wu, N., Venter, J., ... Meng, F.
(2015).
236 miR-34a Regulates Cellular Senescence in Activated Hepatic Stellate Cells During Alcohol Induced Hepatic Injury. Gastroenterology.
148(4), s-974.
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Venter, J., Francis, H., Meng, F., DeMorrow, S., Kennedy, L., Standeford, H., ... Alpini, G.
(2015).
Development and functional characterization of extrahepatic cholangiocyte lines from normal rats. DIGESTIVE AND LIVER DISEASE.
47(11), 964-972.
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Meng, L., Quezada, M., Levine, P., Han, Y., McDaniel, K., Zhou, T., ... Alpini, G.
(2015).
Functional role of cellular senescence in biliary injury. American Journal of Pathology.
185(3), 602-609.
-
Ray, D., Han, Y., Franchitto, A., DeMorrow, S., Meng, F., Venter, J., ... Glaser, S. S.
(2015).
Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine/autocrine mechanisms. American Journal of Pathology.
185(4), 1061-1072.
-
Ehrlich, L., Martinez, A., O'Brien, A., Venter, J., Standeford, H. A., Lairmore, T., Alpini, G., & Glaser, S.
(2015).
Sa1700 The Secretin/Secretin Receptor Axis Modulates Biliary Proliferation Following Cholestatic Injury Through Changes in Menin Expression. Gastroenterology.
148(4), s-1014-s-1015.
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Annable, T., McDaniel, K., Han, Y., Venter, J., Wu, N., Glaser, S., ... Meng, F.
(2015).
Sa1715 Regulation of Cellular Senescence by the microRNA-34a/p53 Axis During Alcoholic Liver Injury. Gastroenterology.
148(4), s-1018-s-1019.
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Han, Y., Wu, N., McDaniel, K., Wan, Y., Venter, J., Annable, T., ... Alpini, G.
(2015).
Sa1718 C-Myc-Regulated Biliary Cellular Senescence and Functional Heterogeneity During Cholestatic Liver Injury. Gastroenterology.
148(4), s-1019.
-
Ray, D., Han, Y., Venter, J., Wu, N., Avila, S., Wan, Y., ... Alpini, G.
(2015).
Sa1719 Dark Therapy Protects Mdr2/- Mice From Cholestatic Liver Injury Through miR-34a Regulation of the p53/SIRT-1 Signaling Pathway. Gastroenterology.
148(4), s-1019.
-
Ray, D., Alpini, G., & Glaser, S.
(2014).
Probiotic Bifidobacterium species: potential beneficial effects in diarrheal disorders. Focus on "Probiotic Bifidobacterium species stimulate human SLC26A3 gene function and expression in intestinal epithelial cells". American Journal of Physiology: Cell Physiology.
307(12), C1081-C1083.
-
Han, Y., Onori, P., Meng, F., DeMorrow, S., Venter, J., Francis, H., ... Alpini, G.
(2014).
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis. American Journal of Physiology - Gastrointestinal and Liver Physiology.
307(9), G894-G904.
-
Francis, H., McDaniel, K., Han, Y., Liu, X., Kennedy, L., Yang, F., ... Meng, F.
(2014).
Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury. 289(40), 27526-27539.
-
Li, J., Razumilava, N., Gores, G. J., Walters, S., Mizuochi, T., Mourya, R., ... Bezerra, J. A.
(2014).
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. Journal of Clinical Investigation.
124(7), 3241-3251.
-
Guerrier, M., Attili, F., Alpini, G., & Glaser, S.
(2014).
Prolonged administration of secretin to normal rats increases biliary proliferation and secretin-induced ductal secretory activity. HepatoBiliary Surgery and Nutrition.
3(3), 118-125.
-
Meng, F., DeMorrow, S., Venter, J., Frampton, G., Han, Y., Francis, H., ... Alpini, G.
(2014).
Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth. American Journal of Physiology - Gastrointestinal and Liver Physiology.
306(9), G759-G768.
-
McDaniel, K., Herrera, L., Zhou, T., Francis, H., Han, Y., Levine, P., ... Meng, F.
(2014).
The functional role of microRNAs in alcoholic liver injury. Journal of Cellular and Molecular Medicine.
18(2), 197-207.
-
Milad, M., McDaniel, K., Han, Y., Quezada, M., Francis, H. L., Glaser, S., ... Meng, F.
(2014).
698 Signal Transducer and Activator of Transcription (STAT)-3 Regulates MicroRNA Gene Expression in Alcoholic Steatohepatitis. Gastroenterology.
146(5), s-923.
-
Sabbatini, M. E., Gorelick, F., & Glaser, S.
(2014).
Adenylyl cyclases in the digestive system. Cellular Signalling.
26(6), 1173-1181.
-
Martnez, A. K., & Glaser, S. S.
(2014).
Cholangiocyte lipoapoptosis: implications for biliary damage during nonalcoholic fatty liver disease. HEPATOLOGY.
60(6), 1809-1811.
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Dostal, D. E., Feng, H., Nizamutdinov, D., Golden, H. B., Afroze, S. H., Dostal, J. D., ... Gerilechaogetu, F.
(2014).
Mechanosensing and Regulation of Cardiac Function. Journal of Clinical and Experimental Cardiology.
5(6), 314.
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Martnez, A. K., Maroni, L., Marzioni, M., Ahmed, S. T., Milad, M., Ray, D., Alpini, G., & Glaser, S. S.
(2014).
Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies. Current Pathobiology Reports.
2(4), 143-153.
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Lleo, A., Maroni, L., Glaser, S., Alpini, G., & Marzioni, M.
(2014).
Role of cholangiocytes in primary biliary cirrhosis. Seminars in Liver Disease.
34(3), 273-284.
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Lairmore, T., Ammarzahid, H., Mat, G., Standeford, H. A., Venter, J., Meng, F., ... Glaser, S.
(2014).
Sa1698 Downregulation of Menin by Mir-24-1 Increases Cholangiocarcinoma Proliferation. Gastroenterology.
146(5), s-954.
-
Ray, D., Venter, J., Meng, F., DeMorrow, S., Standeford, H. A., Francis, H. L., ... Alpini, G.
(2014).
Sa1699 Local Inhibition of Hepatic GnRH by Vivo-Morpholino Reduces Biliary Proliferation and Ameliorates the Expression of Fibrotic Markers in Cholestatic Rats. Gastroenterology.
146(5), s-954.
-
Glaser, S., DeMorrow, S., Meng, F., Venter, J., Standeford, H. A., Francis, H. L., ... Alpini, G.
(2014).
Sa1700 Inhibition of the Substance P/Neurokinin 1 Receptor Signaling Axis Reduces Cholangiocarcinoma Growth In Vivo. Gastroenterology.
146(5), s-954.
-
Glaser, S., Meng, F., Han, Y., Onori, P., Chow, B. K., Francis, H., ... Alpini, G.
(2014).
Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice. Gastroenterology.
146(7), 1795-808.e12.
-
Afroze, S., Meng, F., Jensen, K., McDaniel, K., Rahal, K., Onori, P., ... Glaser, S. S.
(2013).
The physiological roles of secretin and its receptor. Annals of translational medicine.
1(3), 29-8.
-
DeMorrow, S., Meng, F., Venter, J., Leyva-Illades, D., Francis, H., Frampton, G., ... Franchitto, A.
(2013).
Neuropeptide Y inhibits biliary hyperplasia of cholestatic rats by paracrine and autocrine mechanisms. American Journal of Physiology - Gastrointestinal and Liver Physiology.
305(3), G250-G257.
-
Onori, P., Mancinelli, R., Franchitto, A., Carpino, G., Renzi, A., Brozzetti, S., ... Gaudio, E.
(2013).
Role of follicle-stimulating hormone on biliary cyst growth in autosomal dominant polycystic kidney disease. Liver International.
33(6), 914-925.
-
Han, Y., Glaser, S., Meng, F., Francis, H., Marzioni, M., McDaniel, K., ... Franchitto, A.
(2013).
Recent advances in the morphological and functional heterogeneity of the biliary epithelium. Experimental Biology and Medicine.
238(5), 549-565.
-
Jensen, K. J., Alpini, G., & Glaser, S.
(2013).
Hepatic nervous system and neurobiology of the liver. 3(2), 655-665.
-
McDaniel, K., Correa, R., Zhou, T., Johnson, C., Francis, H., Glaser, S., ... Meng, F.
(2013).
Functional role of microvesicles in gastrointestinal malignancies. Annals of translational medicine.
1(1), 4.
-
Lal, H., Verma, S. K., Feng, H., Golden, H. B., Gerilechaogetu, F., Nizamutdinov, D., ... Dostal, D. E.
(2013).
Caveolin and 1-integrin coordinate angiotensinogen expression in cardiac myocytes. International Journal of Cardiology.
168(1), 436-445.
-
Jensen, K., Afroze, S., Ueno, Y., Rahal, K., Frenzel, A., Sterling, M., ... Glaser, S. S.
(2013).
Chronic nicotine exposure stimulates biliary growth and fibrosis in normal rats. DIGESTIVE AND LIVER DISEASE.
45(9), 754-761.
-
Mancinelli, R., Franchitto, A., Glaser, S., Meng, F., Onori, P., Demorrow, S., ... Alpini, G.
(2013).
GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8. HEPATOLOGY.
58(1), 251-263.
-
Renzi, A., DeMorrow, S., Onori, P., Carpino, G., Mancinelli, R., Meng, F., ... Alpini, G.
(2013).
Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats. HEPATOLOGY.
57(3), 1130-1141.
-
Jensen, K., Nizamutdinov, D., Guerrier, M., Afroze, S., Dostal, D., & Glaser, S.
(2012).
General mechanisms of nicotine-induced fibrogenesis. The FASEB Journal.
26(12), 4778-4787.
-
Jensen, K., Marzioni, M., Munshi, K., Afroze, S., Alpini, G., & Glaser, S.
(2012).
Autocrine regulation of biliary pathology by activated cholangiocytes. American Journal of Physiology - Gastrointestinal and Liver Physiology.
302(5), G473-G483.
-
Meng, F., Glaser, S. S., Francis, H., Yang, F., Han, Y., Stokes, A., ... Alpini, G.
(2012).
Epigenetic regulation of miR-34a expression in alcoholic liver injury. American Journal of Pathology.
181(3), 804-817.
-
Meng, F., Francis, H., Glaser, S., Han, Y., DeMorrow, S., Stokes, A., ... Alpini, G.
(2012).
Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration. HEPATOLOGY.
55(1), 209-221.
-
Meng, F., Glaser, S. S., Francis, H., DeMorrow, S., Han, Y., Passarini, J. D., ... Alpini, G.
(2012).
Functional analysis of microRNAs in human hepatocellular cancer stem cells. Journal of Cellular and Molecular Medicine.
16(1), 160-173.
-
Yang, F., Priester, S., Onori, P., Venter, J., Renzi, A., Franchitto, A., ... Glaser, S.
(2011).
Castration inhibits biliary proliferation induced by bile duct obstruction: novel role for the autocrine trophic effect of testosterone. American Journal of Physiology - Gastrointestinal and Liver Physiology.
301(6), G981-G991.
-
Han, Y., Demorrow, S., Invernizzi, P., Jing, Q., Glaser, S., Renzi, A., ... Alpini, G.
(2011).
Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth. American Journal of Physiology - Gastrointestinal and Liver Physiology.
301(4), G623-G633.
-
Renzi, A., Glaser, S., Demorrow, S., Mancinelli, R., Meng, F., Franchitto, A., ... Alpini, G.
(2011).
Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors. American Journal of Physiology - Gastrointestinal and Liver Physiology.
301(4), G634-G643.
-
Glaser, S., Gaudio, E., Renzi, A., Mancinelli, R., Ueno, Y., Venter, J., ... Alpini, G.
(2011).
Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice. American Journal of Physiology - Gastrointestinal and Liver Physiology.
301(2), G297-G305.
-
DeMorrow, S., Onori, P., Venter, J., Invernizzi, P., Frampton, G., White, M., ... Alpini, G.
(2011).
Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion. American Journal of Physiology: Cell Physiology.
300(5), C1078-C1089.
-
Munshi, M. K., Uddin, M. N., & Glaser, S. S.
(2011).
The role of the renin-angiotensin system in liver fibrosis. Experimental Biology and Medicine.
236(5), 557-566.
-
Dutta, A. K., Khimji, A., Kresge, C., Bugde, A., Dougherty, M., Esser, V., ... Feranchak, A. P.
(2011).
Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium. 286(1), 766-776.
-
Alpini, G., Franchitto, A., Demorrow, S., Onori, P., Gaudio, E., Wise, C., ... Glaser, S.
(2011).
Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1. HEPATOLOGY.
53(2), 628-639.
-
Munshi, M. K., Priester, S., Gaudio, E., Yang, F., Alpini, G., Mancinelli, R., ... Glaser, S. S.
(2011).
Regulation of biliary proliferation by neuroendocrine factors: implications for the pathogenesis of cholestatic liver diseases. American Journal of Pathology.
178(2), 472-484.
-
Alpini, G., Glaser, S. S., Zhang, J., Francis, H., Han, Y., Gong, J., ... Meng, F.
(2011).
Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer. Journal of Hepatology.
55(6), 1339-1345.
-
Miller, T., Yang, F., Wise, C. E., Meng, F., Priester, S., Munshi, M. K., ... Glaser, S. S.
(2011).
Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity. DIGESTIVE AND LIVER DISEASE.
43(5), 395-403.
-
Glaser, S., Wang, M., Ueno, Y., Venter, J., Wang, K., Chen, H., Alpini, G., & Holterman, A.
(2010).
Differential transcriptional characteristics of small and large biliary epithelial cells derived from small and large bile ducts. American Journal of Physiology - Gastrointestinal and Liver Physiology.
299(3), G769-G777.
-
Onori, P., Wise, C., Gaudio, E., Franchitto, A., Francis, H., Carpino, G., ... Glaser, S. S.
(2010).
Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor. International Journal of Cancer.
127(1), 43-54.
-
Glaser, S. S., Gaudio, E., & Alpini, G.
(2010).
Vascular factors, angiogenesis and biliary tract disease. Current Opinion in Gastroenterology.
26(3), 246-250.
-
Yang, F., Gaudio, E., Onori, P., Wise, C., Alpini, G., & Glaser, S. S.
(2010).
Mechanisms of Biliary Damage. Journal of Cell Death.
3, 13-21.
-
Woo, K., Sathe, M., Kresge, C., Esser, V., Ueno, Y., Venter, J., ... Feranchak, A. P.
(2010).
Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes. HEPATOLOGY.
52(5), 1819-1828.
-
Mancinelli, R., Franchitto, A., Gaudio, E., Onori, P., Glaser, S., Francis, H., ... Alpini, G.
(2010).
After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes. American Journal of Pathology.
176(4), 1790-1800.
-
Glaser, S. S., & Alpini, G.
(2010).
International hepatology. Journal of Hepatology.
52(3), 450-451.
-
Glaser, S. S., & Alpini, G.
(2010).
Introduction to Mini-Symposium on Cholangiocyte Pathophysiology--Part II. DIGESTIVE AND LIVER DISEASE.
42(6), 389-389.
-
Glaser, S., Lam, I. P., Franchitto, A., Gaudio, E., Onori, P., Chow, B. K., ... Alpini, G.
(2010).
Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. HEPATOLOGY.
52(1), 204-214.
-
Munshi, M. K., Wise, C., Yang, F., Dostal, D. E., & Glaser, S. S.
(2010).
Mechanical Stretch Stimulates Cholangiocyte Proliferation and Profibrotic Gene Expression. The FASEB Journal.
24(S1), 1000.5-1000.5.
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Glaser, S. S., Onori, P., Wise, C., Yang, F., Marzioni, M., Alvaro, D., ... Gaudio, E.
(2010).
Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis. DIGESTIVE AND LIVER DISEASE.
42(4), 245-252.
-
Glaser, S., Onori, P., Gaudio, E., Ueno, Y., Pannarale, L., Franchitto, A., ... Alpini, G.
(2010).
Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats. DIGESTIVE AND LIVER DISEASE.
42(10), 709-717.
-
Fava, G., Demorrow, S., Gaudio, E., Franchitto, A., Onori, P., Carpino, G., ... Alpini, G.
(2009).
Endothelin inhibits cholangiocarcinoma growth by a decrease in the vascular endothelial growth factor expression. Liver International.
29(7), 1031-1042.
-
Mancinelli, R., Onori, P., Gaudio, E., DeMorrow, S., Franchitto, A., Francis, H., ... Alpini, G.
(2009).
Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1. American Journal of Physiology - Gastrointestinal and Liver Physiology.
297(1), G11-G26.
-
Glaser, S. S., Gaudio, E., Rao, A., Pierce, L. M., Onori, P., Franchitto, A., ... Alpini, G. D.
(2009).
Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium. Laboratory Investigation.
89(4), 456-469.
-
Glaser, S. S., Gaudio, E., Miller, T., Alvaro, D., & Alpini, G.
(2009).
Cholangiocyte proliferation and liver fibrosis. Expert Reviews in Molecular Medicine.
11, e7.
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Glaser, S. S., & Alpini, G.
(2009).
Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis. HEPATOLOGY.
49(6), 1795-1797.
-
Strazzabosco, M., Fiorotto, R., Melero, S., Glaser, S., Francis, H., Spirli, C., & Alpini, G.
(2009).
Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. HEPATOLOGY.
50(1), 244-252.
-
Mancino, A., Mancino, M. G., Glaser, S. S., Alpini, G., Bolognese, A., Izzo, L., ... Alvaro, D.
(2009).
Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor. DIGESTIVE AND LIVER DISEASE.
41(2), 156-163.
-
Fava, G., Alpini, G., Rychlicki, C., Saccomanno, S., DeMorrow, S., Trozzi, L., ... Benedetti, A.
(2008).
Leptin enhances cholangiocarcinoma cell growth. Cancer Research.
68(16), 6752-6761.
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Francis, H., Glaser, S., Demorrow, S., Gaudio, E., Ueno, Y., Venter, J., ... Alpini, G.
(2008).
Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway. American Journal of Physiology: Cell Physiology.
295(2), C499-C513.
-
Glaser, S., DeMorrow, S., Francis, H., Ueno, Y., Gaudio, E., Vaculin, S., ... Alpini, G.
(2008).
Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms. American Journal of Physiology - Gastrointestinal and Liver Physiology.
295(1), G124-G136.
-
Uddin, M. N., Horvat, D., Glaser, S. S., Mitchell, B. M., & Puschett, J. B.
(2008).
Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function. Journal of Biological Chemistry.
283(26), 17946-17953.
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Glaser, S. S.
(2008).
Biliary atresia: is lack of innate immune response tolerance key to pathogenesis?. Liver International.
28(5), 587-588.
-
Uddin, M. N., Horvat, D., Glaser, S. S., Danchuk, S., Mitchell, B. M., Sullivan, D. E., Morris, C. A., & Puschett, J. B.
(2008).
Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells. Placenta.
29(3), 266-273.
-
Wise, C., Pilanthananond, M., Perry, B., Alpini, G., McNeal, M., & Glaser, S.
(2008).
Mechanisms of biliary carcinogenesis and growth. WORLD JOURNAL OF GASTROENTEROLOGY.
14(19), 2986-2989.
-
Francis, H., LeSage, G., DeMorrow, S., Alvaro, D., Ueno, Y., Venter, J., ... Alpini, G.
(2007).
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats. American Journal of Physiology: Cell Physiology.
293(4), C1252-C1262.
-
Ueno, Y., Francis, H., Glaser, S., Demorrow, S., Venter, J., Benedetti, A., ... Alpini, G.
(2007).
Taurocholic acid feeding prevents tumor necrosis factor-alpha-induced damage of cholangiocytes by a PI3K-mediated pathway. Experimental Biology and Medicine.
232(7), 942-949.
-
Marzioni, M., Ueno, Y., Glaser, S., Francis, H., Benedetti, A., Alvaro, D., ... Alpini, G.
(2007).
Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver. Liver International.
27(4), 558-568.
-
DeMorrow, S., Glaser, S., Francis, H., Venter, J., Vaculin, B., Vaculin, S., & Alpini, G.
(2007).
Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. 282(17), 13098-13113.
-
Fava, G., Ueno, Y., Glaser, S., Francis, H., Demorrow, S., Marucci, L., ... Alpini, G.
(2007).
Thyroid hormone inhibits biliary growth in bile duct-ligated rats by PLC/IP(3)/Ca(2+)-dependent downregulation of SRC/ERK1/2. American Journal of Physiology: Cell Physiology.
292(4), C1467-C1475.
-
Xia, X., Demorrow, S., Francis, H., Glaser, S., Alpini, G., Marzioni, M., Fava, G., & Lesage, G.
(2007).
Cholangiocyte injury and ductopenic syndromes. Seminars in Liver Disease.
27(4), 401-412.
-
Marzioni, M., Alpini, G., Saccomanno, S., Candelaresi, C., Venter, J., Rychlicki, C., ... Benedetti, A.
(2007).
Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis. Gastroenterology.
133(1), 244-255.
-
Francis, H., Franchitto, A., Ueno, Y., Glaser, S., DeMorrow, S., Venter, J., ... Alpini, G.
(2007).
H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway. Laboratory Investigation.
87(5), 473-487.
-
Glaser, S. S., Ueno, Y., DeMorrow, S., Chiasson, V. L., Katki, K. A., Venter, J., ... Alpini, G. D.
(2007).
Knockout of alpha-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice. Laboratory Investigation.
87(9), 914-926.
-
Fava, G., Marzioni, M., Benedetti, A., Glaser, S., DeMorrow, S., Francis, H., & Alpini, G.
(2007).
Molecular pathology of biliary tract cancers. Cancer Letters.
250(2), 155-167.
-
Taffetani, S., Glaser, S., Francis, H., DeMorrow, S., Ueno, Y., Alvaro, D., ... Alpini, G.
(2007).
Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms. BMC Physiology.
7(1), 6.
-
Alvaro, D., Mancino, M. G., Glaser, S., Gaudio, E., Marzioni, M., Francis, H., & Alpini, G.
(2007).
Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology.
132(1), 415-431.
-
Gaudio, E., Barbaro, B., Alvaro, D., Glaser, S., Francis, H., Franchitto, A., ... Alpini, G.
(2006).
Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats. American Journal of Physiology - Gastrointestinal and Liver Physiology.
291(2), G307-G317.
-
Glaser, S., Alvaro, D., Francis, H., Ueno, Y., Marucci, L., Benedetti, A., ... Alpini, G.
(2006).
Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt. American Journal of Physiology - Gastrointestinal and Liver Physiology.
290(4), G813-G826.
-
Xia, X., Francis, H., Glaser, S., Alpini, G., & LeSage, G.
(2006).
Bile acid interactions with cholangiocytes. WORLD JOURNAL OF GASTROENTEROLOGY.
12(22), 3553-3563.
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Marzioni, M., Francis, H., Benedetti, A., Ueno, Y., Fava, G., Venter, J., ... Glaser, S.
(2006).
Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. American Journal of Pathology.
168(2), 398-409.
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Gaudio, E., Franchitto, A., Pannarale, L., Carpino, G., Alpini, G., Francis, H., ... Onori, P.
(2006).
Cholangiocytes and blood supply. WORLD JOURNAL OF GASTROENTEROLOGY.
12(22), 3546-3552.
-
Marzioni, M., Alpini, G., Saccomanno, S., de Minicis, S., Glaser, S., Francis, H., ... Benedetti, A.
(2006).
Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis. Gastroenterology.
130(6), 1831-1847.
-
Alvaro, D., Barbaro, B., Franchitto, A., Onori, P., Glaser, S. S., Alpini, G., ... Gaudio, E.
(2006).
Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma. American Journal of Pathology.
169(3), 877-888.
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Alvaro, D., Mancino, M. G., Onori, P., Franchitto, A., Alpini, G., Francis, H., Glaser, S., & Gaudio, E.
(2006).
Estrogens and the pathophysiology of the biliary tree. WORLD JOURNAL OF GASTROENTEROLOGY.
12(22), 3537-3545.
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Glaser, S., Francis, H., Demorrow, S., Lesage, G., Fava, G., Marzioni, M., Venter, J., & Alpini, G.
(2006).
Heterogeneity of the intrahepatic biliary epithelium. WORLD JOURNAL OF GASTROENTEROLOGY.
12(22), 3523-3536.
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Gaudio, E., Barbaro, B., Alvaro, D., Glaser, S., Francis, H., Ueno, Y., ... Alpini, G.
(2006).
Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gastroenterology.
130(4), 1270-1282.
-
Fava, G., Marucci, L., Glaser, S., Francis, H., De Morrow, S., Benedetti, A., ... Alpini, G.
(2005).
gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway. Cancer Research.
65(24), 11437-11446.
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Alvaro, D., Metalli, V. D., Alpini, G., Onori, P., Franchitto, A., Barbaro, B., ... Gaudio, E.
(2005).
The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis. Journal of Hepatology.
43(5), 875-883.
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Taffetani, S., Ueno, Y., Meng, F., Venter, J., Francis, H., Glaser, S., Alpini, G., & Patel, T.
(2005).
Tannic acid inhibits cholangiocyte proliferation after bile duct ligation via a cyclic adenosine 5',3'-monophosphate-dependent pathway. 166(6), 1671-1679.
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Alpini, G., Glaser, S., Baiocchi, L., Francis, H., Xia, X., & Lesage, G.
(2005).
Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats. HEPATOLOGY.
41(5), 1037-1045.
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Fava, G., Glaser, S., Francis, H., & Alpini, G.
(2005).
The immunophysiology of biliary epithelium. Seminars in Liver Disease.
25(3), 251-264.
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Marzioni, M., Glaser, S., Francis, H., Marucci, L., Benedetti, A., Alvaro, D., ... Alpini, G.
(2005).
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology.
128(1), 121-137.
-
Alpini, G., Kanno, N., Phinizy, J. L., Glaser, S., Francis, H., Taffetani, S., & LeSage, G.
(2004).
Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. American Journal of Physiology - Gastrointestinal and Liver Physiology.
286(6), G973-G982.
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LeSage, G. D., Alvaro, D., Glaser, S., Francis, H., Marucci, L., Roskams, T., ... Alpini, G.
(2004).
Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP. HEPATOLOGY.
40(5), 1116-1127.
-
Gigliozzi, A., Alpini, G., Baroni, G. S., Marucci, L., Metalli, V. D., Glaser, S. S., ... Alvaro, D.
(2004).
Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis. Gastroenterology.
127(4), 1198-1209.
-
Francis, H., Glaser, S., Ueno, Y., Lesage, G., Marucci, L., Benedetti, A., ... Alpini, G.
(2004).
cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway. Journal of Hepatology.
41(4), 528-537.
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Ueno, Y., Alpini, G., Yahagi, K., Kanno, N., Moritoki, Y., Fukushima, K., ... Shimosegawa, T.
(2003).
Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice. Liver International.
23(6), 449-459.
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Alpini, G., Ueno, Y., Tadlock, L., Glaser, S. S., LeSage, G., Francis, H., ... Patel, T.
(2003).
Increased susceptibility of cholangiocytes to tumor necrosis factor-alpha cytotoxicity after bile duct ligation. American Journal of Physiology: Cell Physiology.
285(1), C183-C194.
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Alpini, G., Phinizy, J. L., Glaser, S., Francis, H., Benedetti, A., Marucci, L., & LeSage, G.
(2003).
Development and characterization of secretin-stimulated secretion of cultured rat cholangiocytes. American Journal of Physiology - Gastrointestinal and Liver Physiology.
284(6), G1066-G1073.
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Marzioni, M., LeSage, G. D., Glaser, S., Patel, T., Marienfeld, C., Ueno, Y., ... Alpini, G.
(2003).
Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats. American Journal of Physiology - Gastrointestinal and Liver Physiology.
284(5), G837-G852.
-
Glaser, S., Alvaro, D., Roskams, T., Phinizy, J. L., Stoica, G., Francis, H., ... Alpini, G.
(2003).
Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity. American Journal of Physiology - Gastrointestinal and Liver Physiology.
284(4), G683-G694.
-
Marucci, L., Alpini, G., Glaser, S. S., Alvaro, D., Benedetti, A., Francis, H., ... LeSage, G.
(2003).
Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism. American Journal of Physiology - Gastrointestinal and Liver Physiology.
284(2), G290-G301.
-
Glaser, S., Alvaro, D., Ueno, Y., Francis, H., Marzioni, M., Phinizy, J. L., ... Alpini, G.
(2003).
Gastrin reverses established cholangiocyte proliferation and enhanced secretin-stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+- dependent PKC isoforms. Liver International.
23(2), 78-88.
-
Baiocchi, L., Alpini, G., Glaser, S., Angelico, M., Alvaro, D., Francis, H., ... LeSage, G.
(2003).
Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. Journal of Hepatology.
38(2), 136-147.
-
Alpini, G., Glaser, S., Alvaro, D., Ueno, Y., Marzioni, M., Francis, H., ... Lesage, G.
(2002).
Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats. Gastroenterology.
123(4), 1226-1237.
-
Alvaro, D., Alpini, G., Onori, P., Franchitto, A., Glaser, S., Le Sage, G., ... Gaudio, E.
(2002).
Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes. Gastroenterology.
123(1), 336-344.
-
Marzioni, M., Glaser, S. S., Francis, H., Phinizy, J. L., LeSage, G., & Alpini, G.
(2002).
Functional heterogeneity of cholangiocytes. Seminars in Liver Disease.
22(3), 227-240.
-
Lesage, G. D., Marucci, L., Alvaro, D., Glaser, S. S., Benedetti, A., Marzioni, M., ... Alpini, G.
(2002).
Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity. HEPATOLOGY.
36(3), 641-651.
-
Kanno, N., Lesage, G., Phinizy, J. L., Glaser, S., Francis, H., & Alpini, G.
(2002).
Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities. HEPATOLOGY.
35(6), 1329-1340.
-
Alpini, G., Baiocchi, L., Glaser, S., Ueno, Y., Marzioni, M., Francis, H., ... Lesage, G.
(2002).
Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. HEPATOLOGY.
35(5), 1041-1052.
-
Kanno, N., LeSage, G., Glaser, S., & Alpini, G.
(2001).
Regulation of cholangiocyte bicarbonate secretion. American Journal of Physiology - Gastrointestinal and Liver Physiology.
281(3), G612-G625.
-
Lesage, G., Glaser, S., Ueno, Y., Alvaro, D., Baiocchi, L., Kanno, N., ... Alpini, G.
(2001).
Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis. American Journal of Physiology - Gastrointestinal and Liver Physiology.
281(1), G182-G190.
-
LeSage, G., Glaser, S., & Alpini, G.
(2001).
Regulation of cholangiocyte proliferation. Liver.
21(2), 73-80.
-
Alpini, G., Ueno, Y., Glaser, S. S., Marzioni, M., Phinizy, J. L., Francis, H., & Lesage, G.
(2001).
Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes. HEPATOLOGY.
34(5), 868-876.
-
Marzioni, M., Glaser, S. S., Alpini, G., & LeSage, G. D.
(2001).
Role of apoptosis in development of primary biliary cirrhosis. DIGESTIVE AND LIVER DISEASE.
33(7), 531-533.
-
Alvaro, D., Alpini, G., Onori, P., Perego, L., Svegliata Baroni, G., Franchitto, A., ... Gaudio, E.
(2000).
Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats. Gastroenterology.
119(6), 1681-1691.
-
Kanno, N., LeSage, G., Glaser, S., Alvaro, D., & Alpini, G.
(2000).
Functional heterogeneity of the intrahepatic biliary epithelium. HEPATOLOGY.
31(3), 555-561.
-
Glaser, S., Benedetti, A., Marucci, L., Alvaro, D., Baiocchi, L., Kanno, N., ... Alpini, G.
(2000).
Gastrin inhibits cholangiocyte growth in bile duct-ligated rats by interaction with cholecystokinin-B/Gastrin receptors via D-myo-inositol 1,4,5-triphosphate-, Ca(2+)-, and protein kinase C alpha-dependent mechanisms. HEPATOLOGY.
32(1), 17-25.
-
LeSage, G., Glaser, S., & Alpini, G.
(2000).
Regulatory mechanisms of ductal bile secretion. DIGESTIVE AND LIVER DISEASE.
32(7), 563-566.
-
Alvaro, D., Benedetti, A., Marucci, L., Delle Monache, M., Monterubbianesi, R., Di Cosimo, E., ... Alpini, G.
(2000).
The function of alkaline phosphatase in the liver: regulation of intrahepatic biliary epithelium secretory activities in the rat. HEPATOLOGY.
32(2), 174-184.
-
LeSage, G. D., Glaser, S. S., Marucci, L., Benedetti, A., Phinizy, J. L., Rodgers, R., ... Alpini, G.
(1999).
Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver. AMERICAN JOURNAL OF PHYSIOLOGY.
276(5), G1289-G1301.
-
LeSage, G. D., Benedetti, A., Glaser, S., Marucci, L., Tretjak, Z., Caligiuri, A., ... Alpini, G.
(1999).
Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver. HEPATOLOGY.
29(2), 307-319.
-
Alpini, G., Glaser, S. S., Ueno, Y., Rodgers, R., Phinizy, J. L., Francis, H., ... LeSage, G. D.
(1999).
Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion. Gastroenterology.
116(1), 179-186.
-
LeSagE, G., Alvaro, D., Benedetti, A., Glaser, S., Marucci, L., Baiocchi, L., ... Alpini, G.
(1999).
Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct-ligated rats. Gastroenterology.
117(1), 191-199.
-
Wales, M. E., Madison, L. L., Glaser, S. S., & Wild, J. R.
(1999).
Divergent allosteric patterns verify the regulatory paradigm for aspartate transcarbamylase. Journal of Molecular Biology.
294(5), 1387-1400.
-
Baiocchi, L., LeSage, G., Glaser, S., & Alpini, G.
(1999).
Regulation of cholangiocyte bile secretion. Journal of Hepatology.
31(1), 179-191.
-
Caligiuri, A., Glaser, S., Rodgers, R. E., Phinizy, J. L., Robertson, W., Papa, E., Pinzani, M., & Alpini, G.
(1998).
Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes. AMERICAN JOURNAL OF PHYSIOLOGY.
275(4), G835-G846.
-
Alpini, G., Glaser, S. S., Ueno, Y., Pham, L., Podila, P. V., Caligiuri, A., LeSage, G., & LaRusso, N. F.
(1998).
Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. AMERICAN JOURNAL OF PHYSIOLOGY.
274(4), G767-G775.
-
Glaser, S. S., Rodgers, R. E., Phinizy, J. L., Robertson, W. E., Lasater, J., Caligiuri, A., ... Alpini, G.
(1997).
Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes. AMERICAN JOURNAL OF PHYSIOLOGY.
273(5), G1061-G1070.
-
Alvaro, D., Alpini, G., Jezequel, A. M., Bassotti, C., Francia, C., Fraioli, F., ... Benedetti, A.
(1997).
Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions. Journal of Clinical Investigation.
100(6), 1349-1362.
-
Alpini, G., Glaser, S., Robertson, W., Phinizy, J. L., Rodgers, R. E., Caligiuri, A., & LeSage, G.
(1997).
Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes. AMERICAN JOURNAL OF PHYSIOLOGY.
273(2 Pt 1), G518-G529.
-
Alpini, G., Glaser, S., Robertson, W., Rodgers, R. E., Phinizy, J. L., Lasater, J., & LeSage, G. D.
(1997).
Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion. AMERICAN JOURNAL OF PHYSIOLOGY.
272(5 Pt 1), G1064-G1074.
-
Alpini, G., Glaser, S. S., Rodgers, R., Phinizy, J. L., Robertson, W. E., Lasater, J., ... LeSage, G. D.
(1997).
Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes. Gastroenterology.
113(5), 1734-1740.
-
Alpini, G., Elias, I., Glaser, S. S., Rodgers, R. E., Phinizy, J. L., Robertson, W. E., ... LeSage, G. D.
(1997).
gamma-Interferon inhibits secretin-induced choleresis and cholangiocyte proliferation in a murine model of cirrhosis. Journal of Hepatology.
27(2), 371-380.
-
Alvaro, D., Alpini, G., Jezequel, A. M., Bassotti, C., Francia, C., Fraioli, F., ... Benedetti, A.
(1997).
Erratum: (Journal of Clinical Investigation (September 1997) 100:6 (1349-1362)). Journal of Clinical Investigation.
100(8), 2141.
-
Lesage, G., Glaser, S. S., Gubba, S., Robertson, W. E., Phinizy, J. L., Lasater, J., Rodgers, R. E., & Alpini, G.
(1996).
Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion. Gastroenterology.
111(6), 1633-1644.
-
Wu, N., Wan, Y., Han, Y., Annable, T., Ray, D., Venter, J., ... Alpini, G.
457 Impact of MT2 Melatonin Receptor Deletion on Cellular Senescence in Cholangiocytes Isolated From Mice After Cholestatic Liver Injury. Gastroenterology.
148(4), s-980.
-
Kennedy, L., Francis, H. L., Meng, F., Venter, J., Hargrove, L., Glaser, S., & Alpini, G.
510 microRNA-21 Increases Liver Fibrosis via Modulation of TGF-1/SMAD Signaling in Bile Duct Ligated (BDL) Mice. Gastroenterology.
150(4), s1038-s1039.
-
McDaniel, K., Han, Y., Wan, Y., Venter, J., Ray, D., Francis, H. L., ... Alpini, G.
803 microRNA Regulation of Functional Heterogeneity in Human Cholangiocytes. Gastroenterology.
148(4), s-996.
-
Kanno, N., Glaser, S., Chowdhury, U., Phinizy, J. L., Baiocchi, L., Francis, H., LeSage, G., & Alpini, G.
Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-alpha. Journal of Hepatology.
34(2), 284-291.
-
Guo, X., Li, H., Zhu, B., Wang, X., Xu, Q., Aquino, E., ... Wu, C.
HFD Feeding for Seven Months Abolishes STING Disruption-driven but not Female Sex-based Protection against Hepatic Steatosis and Inflammation in Mice: HFD feeding alters MASLD. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
109770-109770.
-
Kyritsi, K., Wu, N., Zhou, T., Carpino, G., Baiocchi, L., Kennedy, L., ... Alpini, G.
(2023).
Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity. 13(1), 5.
-
chapter
-
Ray, D., Han, Y., Maroni, L., Marzioni, M., Meng, F., Alpini, G., & Glaser, S.
(2015).
Liver Regeneration. Liver Regeneration.
(pp. 229-241).
Elsevier.
-
H. Afroze, S., Jensen, K., Rahal, K., Meng, F., Alpini, G., & Glaser, S. S.
(2014).
Liver Regeneration. Regenerative Medicine Applications in Organ Transplantation.
(pp. 375-390).
Elsevier.
-
Feng, H., Gerilechaogetu, F., Golden, H. B., Nizamutdinov, D., Foster, D. M., Glaser, S., & Dostal, D. E.
(2013).
Paracrine communication between mechanically stretched myocytes and fibroblasts. Baudino, T. A. (Eds.),
Cell-Cell Interactions: Methods and Protocols.
(pp. 57-66).
Humana Press.
-
Gerilechaogetu, F., Feng, H., Golden, H. B., Nizamutdinov, D., Foster, D. M., Glaser, S., & Dostal, D. E.
(2013).
Production of spontaneously beating neonatal rat heart tissue for calcium and contractile studies. Baudino, T. A. (Eds.),
Cell-Cell Interactions: Methods and Protocols.
(pp. 45-56).
Humana Press.
-
LeSage, G. D., Glaser, S. S., Francis, H., Phinizy, J. L., & Alpini, G.
(2004).
2. FUNCTIONAL HETEROGENEITY OF INTRAHEPATIC CHOLANGIOCYTES. Principles of Medical Biology.
The Liver in Biology and Disease.
(pp. 21-48).
Elsevier.
-
Ray, D., Han, Y., Maroni, L., Marzioni, M., Meng, F., Alpini, G., & Glaser, S.
(2015).
Liver Regeneration. Liver Regeneration.
(pp. 229-241).
Elsevier.
-
conference paper
-
Fava, G., Marzioni, M., Francis, H., Glaser, S., Demorrrow, S., Ueno, Y., Benedetti, A., & Alpini, G.
(2007).
Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function. Hepatology Research.
S420-S429.
-
Alvaro, D., Alpini, G., Onori, P., Franchitto, A., Glaser, S. S., Le Sage, G., ... Gaudio, E.
(2002).
Alfa and beta estrogen receptors and the biliary tree. Molecular and Cellular Endocrinology.
105-108.
-
Fava, G., Marzioni, M., Francis, H., Glaser, S., Demorrrow, S., Ueno, Y., Benedetti, A., & Alpini, G.
(2007).
Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function. Hepatology Research.
S420-S429.
Research
principal investigator on
co-principal investigator on
- Growth Regulation of the Intrahepatic Biliary Tree awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2019
- Role of Sensory Neuropeptides in the Regulation of Biliary Function awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2018
- Regulation of Bile Duct Growth in Bile Duct Ligated Rats awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2012 - 2016
investigator on
- Regulation Of Biliary Growth And Fibrosis By Melatonin awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2019
- Role Of Stem Cell Derived Microvesicles In Alcoholic Liver Injury awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2019
- The Role of Stem Cell Derived Microvesicles in Cholestatic Liver Injury awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2015 - 2019
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- MEID706 Metabolism, Gi, Nutrition Instructor
- MEID707 Endo/repro Sci, Hum Sexuality Instructor
- MSCI685 Directed Studies Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Medical Sciences, Texas A&M Health Science Center - (College Station, Texas, United States) 2006
- M.S. in Biochemistry, Texas A&M University - (College Station, Texas, United States) 1994
- B.S. in Biochemistry, Texas A&M University - (College Station, Texas, United States) 1991
Contact
first name
- Shannon
has last name
- Glaser
mailing address
-
Texas A&M University School of Medicine
Department of Medical Physiology
Bryan, Texas 77807
USA
Other
In the News
- sglaser@tamu.edu