Adenylyl cyclases in the digestive system. Academic Article uri icon


  • Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.

published proceedings

  • Cell Signal

altmetric score

  • 0.5

author list (cited authors)

  • Sabbatini, M. E., Gorelick, F., & Glaser, S.

citation count

  • 13

complete list of authors

  • Sabbatini, Maria Eugenia||Gorelick, Fred||Glaser, Shannon

publication date

  • January 2014