HR job title
- Retired Professor
- Contact Info
- 1 979 845 5167
Smith, Roger Professor
Positions
Application of flow cytometry to study of animal disease and clinical veterinary medicine; core flow cytometry laboratory.
- Overview
- Publications
- Research
- Teaching
- Background
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Overview
Publications
selected publications
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academic article
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Ciepluch, B., Wilson-Robles, H., Levine, G., Smith, R., Wright, G. A., Miller, T., O'Brien, M. T., & Thieman Mankin, K. M.
(2018).
Removal of hemangiosarcoma cells from canine blood with a cell salvage system and leukocyte reduction filter. Veterinary Surgery.
47(2), 293-301.
-
Bearden, R. N., Huggins, S. S., Cummings, K. J., Smith, R., Gregory, C. A., & Saunders, W. B.
(2017).
In-vitro characterization of canine multipotent stromal cells isolated from synovium, bone marrow, and adipose tissue: a donor-matched comparative study. Stem Cell Research and Therapy.
8(1), 218.
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Joswig, A., Mitchell, A., Cummings, K. J., Levine, G. J., Gregory, C. A., Smith, R., & Watts, A. E.
(2017).
Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model. Stem Cell Research and Therapy.
8(1), 42.
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Mitchell, A., Rivas, K. A., Smith, R., & Watts, A. E.
(2015).
Cryopreservation of equine mesenchymal stem cells in 95% autologous serum and 5% DMSO does not alter post-thaw growth or morphology in vitro compared to fetal bovine serum or allogeneic serum at 20 or 95% and DMSO at 10 or 5. Stem Cell Research and Therapy.
6(1), 231.
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Mori, S., Williams, H., Cagle, D., Karanovich, K., Horgen, F. D., Smith, R., & Watanabe, C.
(2015).
Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity. Marine Drugs.
13(10), 6274-6290.
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Steelman, A. J., Smith, R., Welsh, C. J., & Li, J.
(2013).
Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. Journal of Biological Chemistry.
288(33), 23776-23787.
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Hoose, S. A., Trinh, J. T., Leitch, M. C., Kelly, M. M., McCormick, R. F., Spyrou, C. L., Smith, R., & Polymenis, M.
(2013).
Saccharomyces cerevisiae deletion strains with complex DNA content profiles. FEMS Microbiology Letters.
345(1), 72-76.
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Kaur, J., Karthikeyan, R., & Smith, R.
(2013).
Assessment of Escherichia coli reactivation after photocatalytic water disinfection using flow cytometry: comparison with a culture-based method. 13(3), 816-825.
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Hoose, S. A., Duran, C., Malik, I., Eslamfam, S., Shasserre, S. C., Downing, S. S., ... Polymenis, M.
(2012).
Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine. PLoS ONE.
7(5), e36503-e36503.
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Hoose, S. A., Rawlings, J. A., Kelly, M. M., Leitch, M. C., Ababneh, Q. O., Robles, J. P., ... Polymenis, M.
(2012).
A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division. PLOS Genetics.
8(3), e1002590-e1002590.
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Pohlenz, C., Buentello, A., Criscitiello, M. F., Mwangi, W., Smith, R., & Gatlin, D. M.
(2012).
Synergies between vaccination and dietary arginine and glutamine supplementation improve the immune response of channel catfish against Edwardsiella ictaluri. Fish and Shellfish Immunology.
33(3), 543-551.
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Hyde, J. A., Shaw, D. K., Smith, R., Trzeciakowski, J. P., & Skare, J. T.
(2010).
Characterization of a conditional bosR mutant in Borrelia burgdorferi. Infection and Immunity.
78(1), 265-274.
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Hyde, J. A., Shaw, D. K., Smith Iii, R., Trzeciakowski, J. P., & Skare, J. T.
(2009).
The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete. Molecular Microbiology.
74(6), 1344-1355.
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Chintharlapalli, S., Papineni, S., Abdelrahim, M., Abudayyeh, A., Jutooru, I., Chadalapaka, G., ... Safe, S.
(2009).
Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells. International Journal of Cancer.
125(8), 1965-1974.
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Khounlotham, M., Subbian, S., Smith, R., Cirillo, S., & Cirillo, J. D.
(2009).
Mycobacterium tuberculosis interferes with the response to infection by inducing the host EphA2 receptor. Journal of Infectious Diseases.
199(12), 1797-1806.
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Stoica, G., Lungu, G., Martini-Stoica, H., Waghela, S., Levine, J., & Smith, R.
(2009).
Identification of cancer stem cells in dog glioblastoma. Veterinary Pathology.
46(3), 391-406.
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Kim, W., Fan, Y., Smith, R., Patil, B., Jayaprakasha, G. K., McMurray, D. N., & Chapkin, R. S.
(2009).
Dietary curcumin and limonin suppress murine CD4(+) T-cell activation. The FASEB Journal.
23(S1), 110.6-110.6.
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Drechsler, Y., Bohls, R. L., Smith, R., Silvy, N., Lillehoj, H., & Collisson, E. W.
(2009).
An avian, oncogenic retrovirus replicates in vivo in more than 50% of CD4+ and CD8+ T lymphocytes from an endangered grouse. Virology.
386(2), 380-386.
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Bissett, W., Smith, R., Garry Adams, L., Field, R., Moyer, W., Phillips, T., ... Thompson, J. A.
(2009).
An evaluation of the health status of the Lavaca Bay, Texas ecosystem using Crassostrea virginica as the sentinel species. MARINE POLLUTION BULLETIN.
58(2), 280-286.
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Bissett, W., Smith, R., Adams, L. G., Field, R., Moyer, W., Phillips, T., Scott, H. M., & Thompson, J. A.
(2009).
Geostatistical analysis of biomarkers of genotoxicity in cattle, Bos taurus and Bos taurus x Bos indicus, sentinels near industrial facilities. Ecotoxicology.
18(1), 87-93.
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Steelman, A. J., Dean, D. D., Young, C. R., Smith, R., Prentice, T. W., Meagher, M. W., & Welsh, C.
(2009).
Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection. Brain, Behavior, and Immunity.
23(6), 830-843.
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Steelman, A., Dean, D., Young, C. R., Smith, R., Meagher, M., & Welsh, J.
(2008).
Effects of restraint stress on adaptive immune responses to acute Theiler's virus infection in SJL mice. JOURNAL OF NEUROIMMUNOLOGY.
203(2), 152-152.
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Chadalapaka, G., Jutooru, I., Chintharlapalli, S., Papineni, S., Smith, R., Li, X., & Safe, S.
(2008).
Curcumin decreases specificity protein expression in bladder cancer cells. 68(13), 5345-5354.
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Vanderlaag, K., Su, Y., Frankel, A. E., Grage, H., Smith, R., Khan, S., & Safe, S.
(2008).
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways. Breast Cancer Research and Treatment.
109(2), 273-283.
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Kelly, G. T., Liu, C., Smith, R., Coleman, R. S., & Watanabe, C.
(2006).
Cellular effects induced by the antitumor agent azinomycin B. Chemistry and Biology.
13(5), 485-492.
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Bohls, R. L., Smith, R., Ferro, P. J., Silvy, N. J., Li, Z., & Collisson, E. W.
(2006).
The use of flow cytometry to discriminate avian lymphocytes from contaminating thrombocytes. Developmental and Comparative Immunology.
30(9), 843-850.
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Zhang, S., Li, X., Burghardt, R., Smith, R., & Safe, S. H.
(2005).
Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells. Journal of Molecular Endocrinology.
35(3), 433-447.
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Ly, L. H., Smith, R., Chapkin, R. S., & McMurray, D. N.
(2005).
Dietary n-3 polyunsaturated fatty acids suppress splenic CD4(+) T cell function in interleukin (IL)-10(-/-) mice. CLINICAL AND EXPERIMENTAL IMMUNOLOGY.
139(2), 202-209.
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Abdelrahim, M., Smith, R., Burghardt, R., & Safe, S.
(2004).
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells. Cancer Research.
64(18), 6740-6749.
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Chintharlapalli, S., Smith, R., Samudio, I., Zhang, W., & Safe, S.
(2004).
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells. Cancer Research.
64(17), 5994-6001.
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Qin, C., Morrow, D., Stewart, J., Spencer, K., Porter, W., Smith, R., ... Safe, S.
(2004).
A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. MOLECULAR CANCER THERAPEUTICS.
3(3), 247-260.
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Puebla-Osorio, N., Ramos, K. S., Falahatpisheh, M. H., Smith, R., & Berghman, L. R.
(2004).
2,3,7,8-Tetrachlorodibenzo-p-dioxin elicits aryl hydrocarbon receptor-mediated apoptosis in the avian DT40 pre-B-cell line through activation of caspases 9 and 3. Comparative Biochemistry and Physiology C: Toxicology and Pharmacology.
138(4), 461-468.
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Morrow, D., Qin, C., Smith, R., & Safe, S.
(2004).
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. The Journal of Steroid Biochemistry and Molecular Biology.
88(1), 27-36.
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Chaffin, M. K., Cohen, N. D., Martens, R. J., Edwards, R. F., Nevill, M., & Smith, R.
(2004).
Hematologic and immunophenotypic factors associated with development of Rhodococcus equi pneumonia of foals at equine breeding farms with endemic infection. Veterinary Immunology and Immunopathology.
100(1-2), 33-48.
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Abdelrahim, M., Smith, R., & Safe, S.
(2003).
Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. Molecular Pharmacology.
63(6), 1373-1381.
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Khare, S., Banai, Y., Gokulan, K., Smith, R., Linthicum, D. S., & Modiano, J. F.
(2003).
Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs. European Journal of Pharmacology.
465(1-2), 23-30.
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Qin, C., Burghardt, R., Smith, R., Wormke, M., Stewart, J., & Safe, S.
(2003).
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. Cancer Research.
63(5), 958-964.
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Atshaves, B. P., Storey, S. M., Petrescu, A., Greenberg, C. C., Lyuksyutova, O. I., Smith, R., & Schroeder, F.
(2002).
Expression of fatty acid binding proteins inhibits lipid accumulation and alters toxicity in L cell fibroblasts. American Journal of Physiology: Cell Physiology.
283(3), C688-C703.
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Abdelrahim, M., Samudio, I., Smith, R., Burghardt, R., & Safe, S.
(2002).
Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells. Journal of Biological Chemistry.
277(32), 28815-28822.
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Botos, J., Smith, R., & Kochevar, D. T.
(2002).
Retinoblastoma function is a better indicator of cellular phenotype in cultured breast adenocarcinoma cells than retinoblastoma expression. Experimental Biology and Medicine.
227(5), 354-362.
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Smith, R., & Thomas, J. S.
(2002).
Quantitation of reticulated platelets in healthy dogs and in nonthrombocytopenic dogs with clinical disease. Veterinary Clinical Pathology.
31(1), 26-32.
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Tennakoon, D. K., Smith, R., Stewart, M. D., Spencer, T. E., Nayak, M., & Welsh, C. J.
(2001).
Ovine IFN-tau modulates the expression of MHC antigens on murine cerebrovascular endothelial cells and inhibits replication of Theiler's virus. Journal of Interferon and Cytokine Research.
21(10), 785-792.
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Miller, S., Kennedy, D., Thomson, J., Han, F., Smith, R., Ing, N., Piedrahita, J., & Busbee, D.
(2000).
A rapid and sensitive reporter gene that uses green fluorescent protein expression to detect chemicals with estrogenic activity. TOXICOLOGICAL SCIENCES.
55(1), 69-77.
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Ritt, M. G., Mayor, J., Wojcieszyn, J., Smith, R., Barton, C. L., & Modiano, J. F.
(2000).
Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition. Cancer Letters.
158(1), 73-84.
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Cole, D. J., Snowden, K., Cohen, N. D., & Smith, R.
(1999).
Detection of Cryptosporidium parvum in horses: thresholds of acid-fast stain, immunofluorescence assay, and flow cytometry. 37(2), 457-460.
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Modiano, J. F., Ritt, M. G., Wojcieszyn, J., & Smith, R.
(1999).
Growth arrest of melanoma cells is differentially regulated by contact inhibition and serum deprivation. DNA and Cell Biology.
18(5), 357-367.
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Crow, R. T., Rosenbaum, B., Smith, R., Guo, Y., Ramos, K. S., & Sulikowski, G. A.
(1999).
Landomycin A inhibits DNA synthesis and G1/S cell cycle progression. Bioorganic and Medicinal Chemistry Letters.
9(12), 1663-1666.
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Tuo, W., Brown, W. C., Roger, E., Zhu, D., Lin, G., Smith, R., & Bazer, F. W.
(1998).
Trophoblast IFN-tau differentially induces lymphopenia and neutropenia in lambs. Journal of Interferon and Cytokine Research.
18(9), 731-737.
-
Wang, W., Smith, R., & Safe, S.
(1998).
Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes. Archives of Biochemistry and Biophysics.
356(2), 239-248.
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Seo, S. H., Wang, L., Smith, R., & Collisson, E. W.
(1997).
The carboxyl-terminal 120-residue polypeptide of infectious bronchitis virus nucleocapsid induces cytotoxic T lymphocytes and protects chickens from acute infection. Journal of Virology.
71(10), 7889-7894.
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Wang, W., Smith, R., Burghardt, R., & Safe, S. H.
(1997).
17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects. Molecular and Cellular Endocrinology.
133(1), 49-62.
-
Welsh, C. J., Sapatino, B. V., Rosenbaum, B. A., & Smith, R.
(1995).
Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection. JOURNAL OF NEUROIMMUNOLOGY.
62(2), 119-125.
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Sapatino, B. V., Petrescu, A. D., Rosenbaum, B. A., Smith, R., Piedrahita, J. A., & Welsh, C. J.
(1995).
Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. II. Persistent infection. JOURNAL OF NEUROIMMUNOLOGY.
62(2), 127-135.
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Fernandez, P., Burghardt, R., Smith, R., Nodland, K., & Safe, S.
(1994).
High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness. European Journal of Pharmacology.
270(1), 53-65.
-
Woods, P. R., Gossett, R. E., Jain, N. C., Smith, R., Rappaport, E. S., & Kasari, T. R.
(1993).
Acute myelomonocytic leukemia in a calf. Journal of the American Veterinary Medical Association.
203(11), 1579-1582.
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Welsh, J., Sapatino, B., Rosenbaum, B., Smith, R., & Linthicum, S.
(1993).
Correlation between susceptibility to demyelination and interferon-gamma induction of major histocompatibility complex class II antigens on murine cerebrovascular endothelial cells. JOURNAL OF NEUROIMMUNOLOGY.
48(1), 91-97.
-
Ciepluch, B., Wilson-Robles, H., Levine, G., Smith, R., Wright, G. A., Miller, T., O'Brien, M. T., & Thieman Mankin, K. M.
(2018).
Removal of hemangiosarcoma cells from canine blood with a cell salvage system and leukocyte reduction filter. Veterinary Surgery.
47(2), 293-301.
-
conference paper
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Kasaraneni, N., Emanuelli, A., Wright, G., Smith, R., & Chen, Z.
(2017).
Versatile Retargeting Lentiviral System Bearing an Isopeptide Bond Pair SpyTag-SpyCatcher. MOLECULAR THERAPY.
323-323.
-
Steelman, A. J., Smith, R., Welsh, C. J., & Li, J.
(2013).
Galectin-9 is upregulated in astrocytes by proinflammatory cytokines and suppresses encephalitogenic T-cells in the CNS. Journal of Neurochemistry.
135-135.
-
Steelman, A., Smith, R., Welsh, C. J., & Li, J.
(2012).
Galectin-9 is up-regulated in astrocytes by TNF and promotes encephalitogenic T-cell apoptosis. JOURNAL OF NEUROIMMUNOLOGY.
116-116.
-
Kaur, J., Karthikeyan, R., & Smith, R.
(2011).
Effect of advanced photocatalysis on pathogen reactivation rates after UV disinfection in water. 4008-4014.
-
Kim, W., Zhang, P., Smith, R., McMurray, D. N., & Chapkin, R. S.
(2006).
Dietary fish oil alters the accumulation of antigen-specific CD4(+) T cells in the lymph nodes of recipient mice following adoptive transfer and immunization. The FASEB Journal.
A124-A124.
-
Zhang, P., Smith, R., McMurray, D. N., & Chapkin, R. S.
(2005).
Dietary fish oil suppresses clonal expansion during antigen-stimulated marine Th1 differentiation. The FASEB Journal.
A1343-A1343.
-
Ly, L., Smith, R., Chapkin, R., & McMurray, D.
(2004).
Immunosuppressive dietary n-3 polyunsaturated fatty acids enhance CTLA-4 receptor surface expression on CD4(+) murine T-cells. The FASEB Journal.
A160-A161.
-
Zhang, P., Smith, R., McMurray, D. N., & Chapkin, R. S.
(2004).
Dietary fish oil does not affect proliferation or cytokine production in marine CD4(+) T cells polarized toward a Th2 phenotype in vitro. The FASEB Journal.
A160-A160.
-
Abdelrahim, M., Smith, R., & Safe, S.
(2003).
Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentlally modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. TOXICOLOGICAL SCIENCES.
367-367.
-
Botos, J., Smith, R., & Kochevar, D.
(1998).
Differential cell-cycle related RB expression in breast cancer and immortalized breast epithelial cells. The FASEB Journal.
A1338-A1338.
-
SMITH, R.
(1990).
LYMPHOCYTE-T-MEDIATED MECHANISMS OF ACQUIRED PROTECTIVE IMMUNITY AGAINST BRUCELLOSIS IN CATTLE. 164-190.
-
SMITH, R., KAPATSA, J., FICHT, T. A., & ADAMS, L. G.
(1988).
DIFFERENTIAL RECOGNITION OF BRUCELLAE BY BOVINE T-CELLS. The FASEB Journal.
A882-A882.
-
Kasaraneni, N., Emanuelli, A., Wright, G., Smith, R., & Chen, Z.
(2017).
Versatile Retargeting Lentiviral System Bearing an Isopeptide Bond Pair SpyTag-SpyCatcher. MOLECULAR THERAPY.
323-323.
Research
principal investigator on
Teaching
teaching activities
- VTPB910 Veterinary Immunology Instructor
- VTPB911 Veterinary Microbiology Instructor
- VTPB925 Agents Of Disease I Instructor
Background
education and training
- Ph.D. in Immunology, Baylor College of Medicine - (Houston, Texas, United States) 1984
- D.V.M. in Veterinary Medicine, Texas A&M University - (College Station, Texas, United States) 1977
- B.S. in Veterinary Science, Texas A&M University - (College Station, Texas, United States) 1976
- B.A. in Political Science, Rice University - (Houston, Texas, United States) 1973
awards and honors
Contact
first name
- Roger
has last name
- Smith
mailing address
-
Texas A&M University
Vet Med Pathobiology
4467 TAMU
College Station, TX 77845-4467
USA
Other
- rosmith@tamu.edu