Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity. Academic Article

abstract

• A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 M against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

authors

• Smith, Roger
• Watanabe, Coran

published proceedings

• Mar Drugs

altmetric score

• 1.6

author list (cited authors)

• Mori, S., Williams, H., Cagle, D., Karanovich, K., Horgen, F. D., Smith, R., & Watanabe, C.

citation count

• 11

complete list of authors

• Mori, Shogo||Williams, Howard||Cagle, Davey||Karanovich, Kristopher||Horgen, F David||Smith, Roger||Watanabe, Coran MH

publication date

• January 2015

publisher

• MDPI  Publisher

published in

• Marine Drugs  Journal

keywords

• Cell Cycle
• Cell Division
• Cell Migration Inhibition
• Chemotaxis
• Cyanobacteria
• G2 Phase
• Hawaii
• Humans
• Jurkat Cells
• Leukemia, T-cell
• Macrolactone
• Macrolides
• Polyketide

PubMed Central ID

• 26473885

Digital Object Identifier (DOI)

• 10.3390/md13106274

URI

• https://hdl.handle.net/1969.1/184511

start page

• 6274

end page

• 6290

volume

• 13

issue

• 10

URL

• http%3A%2F%2Fdx.doi.org%2F10.3390%2Fmd13106274