Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity Academic Article uri icon

abstract

  • A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

altmetric score

  • 1.6

author list (cited authors)

  • Mori, S., Williams, H., Cagle, D., Karanovich, K., Horgen, F. D., Smith, R., & Watanabe, C.

citation count

  • 7

publication date

  • October 2015